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Volumn 6, Issue 4, 2009, Pages 271-272

Antiplatelet therapy: The P2Y12 receptor: No active metabolite, no party

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; DRUG METABOLITE; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; TICLOPIDINE; ANTITHROMBOCYTIC AGENT; CYP2C19 PROTEIN, HUMAN; DRUG DERIVATIVE; PURINERGIC P2 RECEPTOR; UNSPECIFIC MONOOXYGENASE;

EID: 67649635751     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2009.29     Document Type: Short Survey
Times cited : (20)

References (9)
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    • De Miguel, A.1    Ibanez, B.2    Badimón, J.J.3
  • 2
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirintreated patients with coronary artery disease
    • wallentin, L. et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirintreated patients with coronary artery disease. Eur. Heart J. 29, 21-30 (2008).
    • (2008) Eur. Heart J. , vol.29 , pp. 21-30
    • Wallentin, L.1
  • 3
    • 56849130022 scopus 로고    scopus 로고
    • Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo
    • erlinge, D. et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J. Am. Coll. Cardiol. 52, 1968-1977 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 1968-1977
    • Erlinge, D.1
  • 4
    • 46049108934 scopus 로고    scopus 로고
    • Antiplatelet drugs: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0672
    • Patrono, C., Baigent, C., Hirsh, J. & Roth, G. Antiplatelet drugs: American College of Chest Physicians evidence-Based Clinical Practice Guidelines (8th edition). Chest 133, 199s-233s (2008). (Pubitemid 351894914)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Patrono, C.1    Baigent, C.2    Hirsh, J.3    Roth, G.4
  • 5
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • wiviott, s. D. et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N. Engl. J. Med. 357, 2001-2015 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1
  • 6
    • 0036379817 scopus 로고    scopus 로고
    • Individual variations of platelet inhibition after loading doses of clopidogrel
    • Järemo, P., Lindahl, T. L., Fransson, s. G. & Richter, A. individual variations of platelet inhibition after loading doses of clopidogrel. J. Intern. Med. 252, 233-238 (2002).
    • (2002) J. Intern. Med. , vol.252 , pp. 233-238
    • Järemo, P.1    Lindahl, T.L.2    Fransson, S.G.3    Richter, A.4
  • 7
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • Mega, J. L. et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N. Engl. J. Med. 360, 354-362 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 354-362
    • Mega, J.L.1
  • 8
    • 60049093774 scopus 로고    scopus 로고
    • Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: Implications for aspirin "resistance"
    • santilli, F. et al. Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance". J. Am. Coll. Cardiol. 53, 667-677 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 667-677
    • Santilli, F.1
  • 9
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    • Clopidogrel, genetics, and drug responsiveness
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    • Freedman, J.E.1    Hylek, E.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.