Microfluidic device to study arterial shear-mediated platelet-surface interactions in whole blood: Reduced sample volumes and well-characterised protein surfaces

Biomedical Microdevices

Volumn 12, Issue 6, 2010, Pages 987-1000

  Kent, Nigel J ^a,c   Basabe Desmonts, Lourdes ^a   Meade, Gerardene ^b   MacCraith, Brian D ^a   Corcoran, Brian G ^a   Kenny, Dermot ^b   Ricco, Antonio J ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Image analysis; Microfluidics; Platelet surface interactions; Protein characterisation; Shear activation

Indexed keywords

CELL-SURFACE INTERACTIONS; CHIP SURFACES; COATING PROCESS; CROSS SECTIONAL AREA; DISEASE STATE; DOSE RESPONSE; FLUID FLOW; HUMAN BLOODS; IMMUNOSTAINING; MICRO-FLUIDIC DEVICES; NOVEL DEVICES; PARALLEL-PLATE FLOW; POINT-OF-CARE DIAGNOSTICS; PROTEIN LAYERS; PROTEIN SURFACE; SAMPLE VOLUME; SHEAR ACTIVATION; SHEAR CONDITIONS; SHEAR RATES; SURFACE COVERAGES; SURFACE INTERACTIONS; VERTICAL WALL; VOLUMETRIC FLOW; VON WILLEBRAND FACTOR; WHOLE BLOOD; WIDTH RATIO;

ACTIVATION ANALYSIS; ATOMIC FORCE MICROSCOPY; BLOOD; COATINGS; DRUG DOSAGE; IMAGE ANALYSIS; MICROFLUIDICS; PLATELETS; PROTEINS; SHEAR DEFORMATION;

FLOW OF FLUIDS;

ABCIXIMAB; CITRIC ACID; VON WILLEBRAND FACTOR;

ANTICOAGULATION; ARTERY; ARTICLE; ASSAY; ATOMIC FORCE MICROSCOPY; BLOOD FLOW; BLOOD SAMPLING; BLOOD VOLUME; CELL INTERACTION; CELL SURFACE; COMPUTER PROGRAM; CONTROLLED STUDY; ELLIPSOMETRY; EQUIPMENT DESIGN; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMMUNOFLUORESCENCE TEST; MEDICAL INSTRUMENTATION; MICROFLUIDIC DEVICE; MICROFLUIDICS; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; SHEAR RATE; SHEAR STRESS; THICKNESS; THROMBOCYTE;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES; ARTERIES; BIOMECHANICS; BLOOD PLATELETS; BLOOD PROTEINS; BLOOD VOLUME; EQUIPMENT DESIGN; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MECHANICAL PROCESSES; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, ATOMIC FORCE; PLATELET ADHESIVENESS; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; SOFTWARE; VON WILLEBRAND FACTOR;

EID: 78049306018     PISSN: 13872176     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10544-010-9453-y     Document Type: Article

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