Bio-active engineered 50nm silica nanoparticles with bone anabolic activity: Therapeutic index, effective concentration, and cytotoxicity profile in vitro

Toxicology in Vitro

Volumn 28, Issue 3, 2014, Pages 354-364

  Ha, Shin Woo ^a   Sikorski, James A ^b   Weitzmann, M Neale ^a,c   Beck, George R ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Medicinal Chemistry and Drug Discovery   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Bone; Osteoblasts; Osteoclasts; Silica nanoparticles; Therapeutic index; Toxicity

Indexed keywords

HYDROXIDE; MACROGOL; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIOLOGICAL ACTIVITY; BONE MARROW CELL; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; LETHALITY; MEDIAN EFFECTIVE CONCENTRATION; MOUSE; NANOENGINEERING; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PARTICLE SIZE; SAFETY; STROMA CELL; SURFACE PROPERTY; TOXICITY TESTING;

BONE; OSTEOBLASTS; OSTEOCLASTS; SILICA NANOPARTICLES; THERAPEUTIC INDEX; TOXICITY;

ANIMALS; BONE DISEASES; CELL LINE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETICS; MESENCHYMAL STROMAL CELLS; NANOPARTICLES; OSTEOBLASTS; OSTEOCLASTS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SILICON DIOXIDE; TOXICITY TESTS;

EID: 84891685221     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.12.001     Document Type: Article

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