Prolonged insulin stimulation down-regulates GLUT4 through oxidative stress-mediated retromer inhibition by a protein kinase CK2-dependent mechanism in 3T3-L1 adipocytes

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 133-142

  Ma, Jinhui ^a   Nakagawa, Yuko ^a   Kojima, Itaru ^a   Shibata, Hiroshi ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DISSOCIATION; ENZYME ACTIVITY; PROTEINS;

3T3-L1 ADIPOCYTES; EXTRACELLULAR- SIGNAL-REGULATED KINASE 1/2; INDUCED DISSOCIATION; INTRACELLULAR COMPARTMENTS; LYSOSOMAL DEGRADATION; MICROSOMAL MEMBRANES; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE CK2;

INSULIN;

CASEIN KINASE II; CELL PROTEIN; GLUCOSE TRANSPORTER 4; HYDROGEN PEROXIDE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN VPS26; PROTEIN VPS35; SORTILIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; LIPOSOME; PHOSPHATIDYLINOSITOL 3 KINASE; SLC2A4 PROTEIN, MOUSE; VESICULAR TRANSPORT ADAPTOR PROTEIN; VESICULAR TRANSPORT PROTEIN; VPS26 PROTEIN, MOUSE; VPS35 PROTEIN, MOUSE;

ADIPOCYTE MEMBRANE; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DEGRADATION KINETICS; DISSOCIATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; INHIBITION KINETICS; LOW DENSITY MICROSOMAL MEMBRANE; MUTATIONAL ANALYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ADIPOCYTE; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENE SILENCING; GENETICS; INTRACELLULAR MEMBRANE; METABOLISM; MICROSOME; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN TRANSPORT;

3T3 CELLS; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADIPOCYTES; ANIMALS; CASEIN KINASE II; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; INTRACELLULAR MEMBRANES; LIPOSOMES; MICE; MICROSOMES; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEOLYSIS; VESICULAR TRANSPORT PROTEINS;

EID: 84891679672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.533240     Document Type: Article

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