Mechanism of action of Trolox on duodenal contractility

Journal of Physiology and Pharmacology

Volumn 64, Issue 6, 2013, Pages

  Fagundes, D S ^a,b   Grasa, L ^a   Gonzalo, S ^a   Martinez de Salinas, F ^a   Arruebo, M P ^a   Plaza, M A ^a   Murillo, M D ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b FEDERAL UNIVERSITY OF AMAPÁ   (Brazil)

Author keywords

Circular smooth muscle; Cyclooygenase 2; Duodenal contractility; Guanylyl cyclase; Longitudinal smooth muscle; Trolox

Indexed keywords

1, 4 DIHYDRO 2, 6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL) PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2', 5' DIDEOXYADENOSINE; 2, 2' AZOBIS (2 AMIDINOPROPANE); ADENYLATE CYCLASE; APAMIN; CALCIUM CHANNEL L TYPE; CHARYBDOTOXIN; GLIBENCLAMIDE; GUANYLATE CYCLASE; NIMESULIDE; POTASSIUM CHANNEL; QUININE; TETRYLAMMONIUM; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM MOTILITY; MALE; MUSCLE ISOMETRIC CONTRACTION; NEW ZEALAND WHITE (RABBIT); NONHUMAN; RABBIT; REGULATORY MECHANISM;

EID: 84891676659     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Fritsma GA. Vitamin E and autoxidation. Am J Med Technol 1983; 49: 453-456.
2. Bjorneboe A, Bjorneboe GE, Drevon A. Absorption, transport and distribution of vitamin E. J Nutr 1990; 120: 233-242.
3. Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem 2001; 57: 43-56.
4. Schneider C. Chemistry and biology of vitamin E. Mol Nutr Food Res 2005; 49: 7-30.
5. Tafazoli S, Wright JS, O'Brien J. Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem Res Toxicol 2005; 18: 1567-1574.
6. Matsumoto S, Leggett RE, Levin RM. The effect of vitamin E on the response of rabbit bladder smooth muscle to hydrogen peroxide. Mol Cell Biochem 2003; 254: 347-351.
7. Koyuturk M, Bolkent S, Ozdil S, Arbak S, Yanardag R. The protective effect of vitamin C, vitamin E and selenium combination therapy on ethanol-induced duodenal mucosal injury. Hum Exp Toxicol 2004; 23: 391-398.
8. Gomez JA, Molero X, Vaquero E, Alonso A, Salas A, Malagelada JR. Vitamin E attenuates biochemical and morphological features associated with development of chronic pancreatitis. Am J Physiol 2004; 287: G162-G169.
9. Godbout JP, Berg BM, Krzyszton C, Johnson RW. Alphα-tocopherol attenuates NFkappaB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior. J Neuroimmunol 2005; 169: 97-105.
10. Park SW, Lee SM. The beneficial effect of Trolox on sepsis-induced hepatic drug metabolizing dysfunction. Arch Pharm Res 2004; 27: 232-238.
11. Sagach VF, Scrosati M, Fielding J, Rossoni G, Galli C, Visioli F. The water-soluble vitamin E analogue Trolox protects against ischaemia/reperfusion damage in vitro and ex vivo. A comparison with vitamin E. Pharmacol Res 2002; 45: 435-439.
12. Fagundes DS, Gonzalo S, Grasa L, et al. Trolox reduces the effect of ethanol on ACh-induced contractions and oxidative stress in the duodenum. Rev Esp Enferm Dig 2011; 103: 396-401.
13. Fagundes DS, Gonzalo S, Arruebo MP, Plaza MA, Murillo MD. Melatonin and Trolox ameliorate duodenal LPS-induced disturbances and oxidative stress. Dig Liver Dis 2010; 40: 40-44.
14. Salehi P, Walker J, Madsen K, Churchill TA. Control of oxidative stress in small bowel: relevance to organ preservation. Surgery 2006; 139: 317-323.
15. Azzi A, Breyer I, Feher M, et al. Specific cellular responses to alphα-tocopherol. J Nutr 2000; 130: 1649-1652.
16. Martin-Nizard F, Boullier A, Fruchart JC, Duriez P. Alphα-tocopherol but not betα-tocopherol inhibits thrombin-induced PKC activation and endothelin secretion in endothelial cells. J Cardiovasc Risk 1998; 5: 339-345.
17. Devaraj S, Jialal I. Alphα-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase. Arterioscler Thromb Vasc Biol 1999; 19: 1125-1133.
18. Fagundes DS, Grasa L, Arruebo MP, Plaza MA, Murillo MD. Ca2+-activated K+ channels involved in duodenal dismotility induced by ethanol. Alcohol Alcohol 2007; 42: 291-295.
19. Lamarca V, Grasa L, Fagundes DS, Arruebo MP, Plaza MA, Murillo MD. K+ channels envolved in contractility of rabbit small intestine. J Physiol Biochem 2006; 62: 227-236.
20. Barona I, Fagundes DS, Gonzalo S, et al. Role of TLR4 and MAPK in the local effect of LPS on intestinal contractility. J Pharm Pharmacol 2011; 63: 657-662.
21. Azzi A, Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res 2000; 39: 231-255.
22. Munteanu A, Zingg JM, Azzi A. Anti-atherosclerotic effects of vitamin E - myth or reality? J Cell Mol Med 2004; 8: 59-76.
23. Horowitz B, Ward SM, Sanders KM. Cellular and molecular basis for electrical rhythmicity in gastrointestinal tract. Annu Rev Physiol 1999; 61: 19-43.
24. Murillo MD, Plaza MA, de Pedro MJ, Arruebo MP. The effect of Ca2+ antagonists on spontaneous motility from sheep duodenum. J Pharm Pharmacol 1994; 46: 138-140.
25. Grasa L, Rebollar E, Arruebo MP, Plaza MA, Murillo MD. The role of Ca2+ in the contractility of rabbit small intestine in vitro. J Physiol Pharmacol 2004; 55: 639-650.
26. Kelly MJ, Mathie AZ, Vallance C. A pharmacological action of vitamin E unrelated to its antioxidant capacity. Methods Find Exp Clin Pharmacol 2006; 28: 499-505.
27. Wade GR, Laurier LG, Preiksaitis HG, Sims SM. Delayed rectifier and Ca2+-dependent K+ currents in human esophagus: roles in regulating muscle contraction. Am J Physiol 1999; 277: G885-G895.
28. Hong SJ, Roan YF, Chang CC. Spontaneous activity of guinea pig ileum longitudinal muscle regulated by Ca2+-activated K+ channel. Am J Physiol 1997; 272: G962-G971.
29. Jing F, Liu M, Yang N, Liu Y, Li X, Li J. Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. J Pharm Pharmacol 2013; 65: 847-854.
30. Nascimento NR, Leal-Cardoso JH, Lessa LM, Roriz-Filho JS, Cunha KM, Fonteles MC. Terpinen-4-ol: mechanisms of relaxation on rabbit duodenum. J Pharm Pharmacol 2005; 57: 467-474.
31. Andreadou I, Iliodromitis EK, Tsovolas K, et al. Acute administration of vitamin E triggers preconditioning via K(ATP) channels and cyclic-GMP without inhibiting lipid peroxidation. Free Radic Biol Med 2006; 41: 1092-1099.
32. Zhu HL, Teramoto N. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba2+ currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol 2008; 378: 609-615.
33. Hernandez L, Grasa L, Fagundes DS, et al. Role of potassium channels in rabbit intestinal motility disorders induced by 2, 2'-azobis (2-amidinopropane) dihydrochloride (AAPH). J Physiol Pharmacol 2010; 61: 279-286.
34. Huang CW, Hung TY, Liao YK, Hsu MC, Wu SN. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theorethical study. J Physiol Pharmacol 2013; 64: 269-280.
35. Zizzo MG, Mule F, Mastropaolo M, Serio R. D1 receptors play a major role in the dopamine modulation of mouse ileum contractility. Pharmacol Res 2010; 61: 371-378.
36. Goetz B, Benhaqi P, Muller MH, Kreis ME, Kasparek MS. Changes in beta-adrenergic neurotransmission during postoperative ileus in rat circular jejunal muscle. Neurogastroenterol Motil 2013; 25: 154-e84.