Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and antiangiogenic activities in gender-specific gene expression in Keshan disease

Chinese Medical Journal

Volumn 127, Issue 1, 2014, Pages 72-78

  He, Shu Lan ^a   Tan, Wu Hong ^a   Wang, Sen ^a   Wu, Cui Yan ^a   Wang, Pan ^a   Wang, Bin ^a   Su, Xiao Hui ^a   Zhao, Jun Jie ^a   Guo, Xiong ^a   Xiang, You Zhang ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Shandong Institute for Prevention and Treatment of Endemic Disease   (China)

Author keywords

Gender; Myocardial diseases; Oligonucleotide microarrays

Indexed keywords

ADULT; ANTIANGIOGENIC ACTIVITY; ARTICLE; AUTOIMMUNITY; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENDER; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; KESHAN DISEASE; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ADAM PROTEINS; ADULT; AUTOIMMUNITY; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 7; CARDIOMYOPATHIES; CELL DIFFERENTIATION; CHEMOKINES, CC; ENTEROVIRUS INFECTIONS; FEMALE; GENE EXPRESSION PROFILING; HLA-D ANTIGENS; HLA-DQ ALPHA-CHAINS; HLA-DR ALPHA-CHAINS; HUMANS; MALE; MIDDLE AGED; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEX FACTORS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15;

EID: 84891665867     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20131167     Document Type: Article

References (27)

1. Yang FY. Keshan disease and mitochondrial cardiomyopathy. Sci China C Life Sci 2006; 49: 513-518.
2. Xiang YZ. P revalence and pathogenesis research in Keshan dis-disease (in Chinese). Chin J Endemiol 2005; 24: 463-465.
3. Xiang YZ. Dynamic observation on incidence changes and epidemic characteristics of Keshan disease in Shandong Province from 1960 to 2007 (in Chinese). Chin J Endemiol 2009; 28: 24-27.
4. Li Q, Liu M, Hou J, Jiang CX, Li SC, Wang T. The prevalence of Keshan disease in China. Int J Cardiol 2012; 2: 1121-1126.
5. Zhu D. Epidemiology investigation in Keshan disease (in Chinese). Heilongjiang Med J 1959; 12: 77-79.
6. Wei HL, Pei JR, Jiang CX, Zhou LW, Lan T, Liu M, et al. Analy-Analysis of glutathione peroxidase 1 gene polymorphism and Keshan disease in Heilongjiang Province, China. Genet Mol Res 2011; 10: 2996-3001.
7. Xiang YZ, Liu FF, Wang XH, Liu Y, Wang J, Zhang WM. Genome-wide gene expression and biological markers analysis in Keshan disease (in Chinese). Chin J Endemiol 2011; 30: 253-254.
8. Ngwa JS, Manning AK, Grimsby JL, Lu C, Zhuang WV, Destefano AL. Pathway analysis following association study. BMC Proc 2011; 5 Suppl 9: S18.
9. Charoudeh HN, Schmied L, Gonzalez A, Terszowski G, Czaja K, Schmitter K, et al. Quantity of HLA-C surface expression and licensing of KIR2DL+ natural killer cells. Immunogenetics 2012; 64: 739-745.
10. Lorenzi S, Forloni M, Cifaldi L, Antonucci C, Citti A, Boldrini R. IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma. PLoS One 2012; 7: e46928.
11. Kloetzel PM, Ossendorp F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 2004; 16: 76-81.
12. Wu ZR, Zhong XK, Xu Yl, Zhou LW, Wu CL. Immune response of the children in low-selenium areas (in Chinese). J Harbin Med Univ 1989; 23: 400-402.
13. Liu WB, Yuan L, Xu XF, Wang J. Observation on T cell subgroup from children with subacute Keshan disease (in Chinese). J Dali Med Coll 1996; 5: 14-15.
14. Elliott JF, Liu J, Yuan ZN, Bautista-Lopez N, Wallbank SL, Suzuki K, et al. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice. Proc Natl Acad Sci USA 2003; 100: 13447-13452.
15. Krco CJ, Pawelski J, Harders J, McCormick D, Griffiths M, Luthra HS, et al. Characterization of the antigenic structure of human type II collagen. J Immunol 1996; 156: 2761-2768.
16. Taneja V, David CS. Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8. NODAbo transgenic mice. J Autoimmun 2009; 33: 260-269.
17. Rodriguez-Perez JM, Fragoso JM, Alvarez-Leon E, Martínez-Rodríguez N, Gallardo GJ, Inés-Real S, et al. MHC class II genes in Mexican patients with idiopathic dilated cardio-myopathy. Exp Mol Pathol 2007; 82: 49-52.
18. Ameling S, Herda LR, Hammer E, Steil L, Teumer A, Trimpert C, et al. Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy. Eur Heart J 2013; 34: 666-675.
19. Monzen K, Nagai R, Komuro I. A role for bone morphogenetic protein signaling in cardiomyocyte differentiation. Trends Cardiovasc Med 2002; 12: 263-269.
20. Lee CW, Hwang I, Park CS, Lee H, Park DW, Kang SJ, et al. Comparison of ADAMTS-1,-4 and-5 expression in culprit plaques between acute myocardial infarction and stable angina. J Clin Pathol 2011; 5: 399-404.
21. Zhao C, Zha Y, Wu X, Chen L, Shi J, Cui L. The quantification of ADAMTS 4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction. Biomed Pharmacother 2011; 65: 555-559.
22. Li GS, Wang F, Kang DR, Li C. Keshan disease: An endemic cardiomyopathy in China. Human Pathol 1985; 6: 602-609.
23. Li GS, Wang F. Studies on the relationship between myocardial necrotic foci and coronary vessels (in Chinese). Chin J Endemiol 1982; 2: 125-129.
24. Dunn JR, Reed JE, du Plessis DG, Shaw EJ, Reeves P, Gee AL, et al. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. Br J Cancer 2006; 94: 1186-1193.
25. Gao L, Wang T, Zhou LW, Gao YH, Li XZ, Pei JR, et al. A study on the relationship between tumor necrosis factor-α and Yunnan endemic sudden cardiac death (in Chinese). Chin J Endemiol 2006; 25: 73-74.
26. Imahara SD, Jelacic S, Junker CE, O'Keefe GE. The influence of gender on human innate immunity. Surgery 2005; 138: 275-282.
27. Niemann JT, Rosborough JP, Youngquist S. Is the tumour necrosis factor-alpha response following resuscitation gender dependent in the swine model? Resuscitation 2008; 77: 258-263.