-
1
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
12700374 10.1056/NEJMoa022139
-
GS Martin DM Mannino S Eaton M Moss 2003 The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 1546 1554 12700374 10.1056/NEJMoa022139
-
(2003)
N Engl J Med
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
Mannino, D.M.2
Eaton, S.3
Moss, M.4
-
2
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
12519925 10.1056/NEJMra021333 1:CAS:528:DC%2BD3sXhtlCitA%3D%3D
-
RS Hotchkiss IE Karl 2003 The pathophysiology and treatment of sepsis N Engl J Med 348 138 150 12519925 10.1056/NEJMra021333 1:CAS:528: DC%2BD3sXhtlCitA%3D%3D
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
3
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
19197294 10.1038/nri2506 1:CAS:528:DC%2BD1MXhsFeqsbw%3D
-
DI Gabrilovich S Nagaraj 2009 Myeloid-derived suppressor cells as regulators of the immune system Nat Rev Immunol 9 162 174 19197294 10.1038/nri2506 1:CAS:528:DC%2BD1MXhsFeqsbw%3D
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
4
-
-
43249130187
-
Identification of discrete tumorâ€induced myeloid†derived suppressor cell subpopulations with distinct T cell†suppressive activity
-
18272812 10.1182/blood-2007-07-099226 1:CAS:528:DC%2BD1cXkvFeisb4%3D
-
K Movahedi M Guilliams J Van den Bossche R Van den Bergh C Gysemans A Beschin P De Baetselier JA Van Ginderachter 2008 Identification of discrete tumorâ€induced myeloidâ€derived suppressor cell subpopulations with distinct T cellâ€suppressive activity Blood 111 4233 4244 18272812 10.1182/blood-2007-07-099226 1:CAS:528:DC%2BD1cXkvFeisb4%3D
-
(2008)
Blood
, vol.111
, pp. 4233-4244
-
-
Movahedi, K.1
Guilliams, M.2
Van Den Bossche, J.3
Van Den Bergh, R.4
Gysemans, C.5
Beschin, A.6
De Baetselier, P.7
Van Ginderachter, J.A.8
-
5
-
-
54049134747
-
Subsets of myeloidâ€derived suppressor cells in tumorâ€bearing mice
-
18832739 1:CAS:528:DC%2BD1cXhtF2hsL3I
-
JI Youn S Nagaraj M Collazo DI Gabrilovich 2008 Subsets of myeloidâ€derived suppressor cells in tumorâ€bearing mice J Immunol 181 5791 5802 18832739 1:CAS:528:DC%2BD1cXhtF2hsL3I
-
(2008)
J Immunol
, vol.181
, pp. 5791-5802
-
-
Youn, J.I.1
Nagaraj, S.2
Collazo, M.3
Gabrilovich, D.I.4
-
6
-
-
77951258918
-
Myeloid-derived suppressor cell heterogeneity and subset definition
-
20171075 10.1016/j.coi.2010.01.021 1:CAS:528:DC%2BC3cXks1Srtr0%3D
-
E Peranzoni S Zilio I Marigo L Dolcetti P Zanovello S Mandruzzato V Bronte 2010 Myeloid-derived suppressor cell heterogeneity and subset definition Curr Opin Immunol 22 238 244 20171075 10.1016/j.coi.2010.01.021 1:CAS:528:DC%2BC3cXks1Srtr0%3D
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 238-244
-
-
Peranzoni, E.1
Zilio, S.2
Marigo, I.3
Dolcetti, L.4
Zanovello, P.5
Mandruzzato, S.6
Bronte, V.7
-
7
-
-
74049097839
-
Stat-6 dependent induction of myeloid-derived suppressor cells after physical injury regulates nitric oxide response to endotoxin
-
20032720 10.1097/SLA.0b013e3181bfda1c
-
V Munera PJ Popovic J Bryk J Pribis D Caba BM Matta M Zenati JB Ochoa 2010 Stat-6 dependent induction of myeloid-derived suppressor cells after physical injury regulates nitric oxide response to endotoxin Ann Surg 251 120 126 20032720 10.1097/SLA.0b013e3181bfda1c
-
(2010)
Ann Surg
, vol.251
, pp. 120-126
-
-
Munera, V.1
Popovic, P.J.2
Bryk, J.3
Pribis, J.4
Caba, D.5
Matta, B.M.6
Zenati, M.7
Ochoa, J.B.8
-
8
-
-
29644442445
-
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
-
16365420 1:CAS:528:DC%2BD2MXhtlagtL7I
-
SK Bunt P Sinha VK Clements J Leips S Ostrand-Rosenberg 2006 Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression J Immunol 176 284 290 16365420 1:CAS:528:DC%2BD2MXhtlagtL7I
-
(2006)
J Immunol
, vol.176
, pp. 284-290
-
-
Bunt, S.K.1
Sinha, P.2
Clements, V.K.3
Leips, J.4
Ostrand-Rosenberg, S.5
-
9
-
-
80051549946
-
Neutrophils, not monocyte/macrophages, are the major splenic source of postburn IL-10
-
21558983 10.1097/SHK.0b013e3182205cbc 1:CAS:528:DC%2BC3MXovFyrsL4%3D
-
G Noel Q Wang S Schwemberger C Hanson N Giacalone L Haar CK Ogle 2011 Neutrophils, not monocyte/macrophages, are the major splenic source of postburn IL-10 Shock 36 149 155 21558983 10.1097/SHK.0b013e3182205cbc 1:CAS:528:DC%2BC3MXovFyrsL4%3D
-
(2011)
Shock
, vol.36
, pp. 149-155
-
-
Noel, G.1
Wang, Q.2
Schwemberger, S.3
Hanson, C.4
Giacalone, N.5
Haar, L.6
Ogle, C.K.7
-
11
-
-
0036798269
-
Immunosuppression during acute Trypanosoma cruzi infection: Involvement of Ly6G (Gr1(+))CD11b(+)immature myeloid suppressor cells. i
-
12356678 10.1093/intimm/dxf076 1:CAS:528:DC%2BD38Xns1ehu7w%3D
-
O Goni P Alcaide M Fresno 2002 Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1(+))CD11b(+)immature myeloid suppressor cells. I Int Immunol 14 1125 1134 12356678 10.1093/intimm/dxf076 1:CAS:528:DC%2BD38Xns1ehu7w%3D
-
(2002)
Int Immunol
, vol.14
, pp. 1125-1134
-
-
Goni, O.1
Alcaide, P.2
Fresno, M.3
-
12
-
-
4544220702
-
Both expansion of regulatory GR1 + CD11b + myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis
-
15322051 10.1128/IAI.72.9.5487-5492.2004 1:CAS:528:DC%2BD2cXnt1Chtrg%3D
-
MB Voisin D Buzoni-Gatel D Bout F Velge-Roussel 2004 Both expansion of regulatory GR1 + CD11b + myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis Infect Immun 72 5487 5492 15322051 10.1128/IAI.72.9.5487-5492.2004 1:CAS:528:DC%2BD2cXnt1Chtrg%3D
-
(2004)
Infect Immun
, vol.72
, pp. 5487-5492
-
-
Voisin, M.B.1
Buzoni-Gatel, D.2
Bout, D.3
Velge-Roussel, F.4
-
13
-
-
80052670103
-
Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection
-
21804013 10.4049/jimmunol.1002928 1:CAS:528:DC%2BC3MXhtVGmsb%2FE
-
H Cuervo NA Guerrero S Carbajosa A Beschin P De Baetselier N Girones M Fresno 2011 Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection J Immunol 187 2656 2665 21804013 10.4049/jimmunol.1002928 1:CAS:528:DC%2BC3MXhtVGmsb%2FE
-
(2011)
J Immunol
, vol.187
, pp. 2656-2665
-
-
Cuervo, H.1
Guerrero, N.A.2
Carbajosa, S.3
Beschin, A.4
De Baetselier, P.5
Girones, N.6
Fresno, M.7
-
14
-
-
82555193654
-
Myeloid-derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses
-
10.1189/jlb.1110608 1:CAS:528:DC%2BC3MXhs1yksLvN
-
WF Pereira FL Ribeiro-Gomes LV Guillermo NS Vellozo F Montalvao GA Dosreis MF Lopes 2011 Myeloid-derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses J Leuk Biol 90 1191 1197 10.1189/jlb.1110608 1:CAS:528:DC%2BC3MXhs1yksLvN
-
(2011)
J Leuk Biol
, vol.90
, pp. 1191-1197
-
-
Pereira, W.F.1
Ribeiro-Gomes, F.L.2
Guillermo, L.V.3
Vellozo, N.S.4
Montalvao, F.5
Dosreis, G.A.6
Lopes, M.F.7
-
15
-
-
80052646150
-
Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus
-
21762128 10.1111/j.1365-2249.2011.04445.x 1:CAS:528:DC%2BC3MXhtlSks7fM
-
S Chen SM Akbar M Abe Y Hiasa M Onji 2011 Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus Clin Exp Immunol 166 134 142 21762128 10.1111/j.1365-2249.2011.04445.x 1:CAS:528:DC%2BC3MXhtlSks7fM
-
(2011)
Clin Exp Immunol
, vol.166
, pp. 134-142
-
-
Chen, S.1
Akbar, S.M.2
Abe, M.3
Hiasa, Y.4
Onji, M.5
-
16
-
-
84863012062
-
Myeloid suppressor cells induced by hepatitis C virus suppress T cell responses through the production of reactive oxygen species
-
doi: 10.1002/hep.24700
-
Tacke R, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR, Hahn YS (2011) Myeloid suppressor cells induced by hepatitis C virus suppress T cell responses through the production of reactive oxygen species. Hepatology. doi: 10.1002/hep.24700
-
(2011)
Hepatology
-
-
Tacke, R.1
Lee, H.C.2
Goh, C.3
Courtney, J.4
Polyak, S.J.5
Rosen, H.R.6
Hahn, Y.S.7
-
17
-
-
34250359119
-
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
-
17548519 10.1084/jem.20062602 1:CAS:528:DC%2BD2sXms1aktLg%3D
-
MJ Delano PO Scumpia JS Weinstein D Coco S Nagaraj KM Kelly-Scumpia KA O'Malley JL Wynn S Antonenko SZ Al-Quran R Swan CS Chung MA Atkinson R Ramphal DI Gabrilovich WH Reeves A Ayala J Phillips D Laface PG Heyworth M Clare-Salzler LL Moldawer 2007 MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis J Exp Med 204 1463 1474 17548519 10.1084/jem.20062602 1:CAS:528:DC%2BD2sXms1aktLg%3D
-
(2007)
J Exp Med
, vol.204
, pp. 1463-1474
-
-
Delano, M.J.1
Scumpia, P.O.2
Weinstein, J.S.3
Coco, D.4
Nagaraj, S.5
Kelly-Scumpia, K.M.6
O'Malley, K.A.7
Wynn, J.L.8
Antonenko, S.9
Al-Quran, S.Z.10
Swan, R.11
Chung, C.S.12
Atkinson, M.A.13
Ramphal, R.14
Gabrilovich, D.I.15
Reeves, W.H.16
Ayala, A.17
Phillips, J.18
Laface, D.19
Heyworth, P.G.20
Clare-Salzler, M.21
Moldawer, L.L.22
more..
-
18
-
-
79952822608
-
A paradoxical role for myeloid derived suppressor cells in sepsis and trauma
-
21085745 10.2119/molmed.2010.00178 1:CAS:528:DC%2BC3MXjvFWgtb0%3D
-
AG Cuenca MJ Delano KM Kelly-Scumpia C Moreno PO Scumpia DM Laface PG Heyworth PA Efron LL Moldawer 2011 A paradoxical role for myeloid derived suppressor cells in sepsis and trauma Mol Med 17 281 292 21085745 10.2119/molmed.2010.00178 1:CAS:528:DC%2BC3MXjvFWgtb0%3D
-
(2011)
Mol Med
, vol.17
, pp. 281-292
-
-
Cuenca, A.G.1
Delano, M.J.2
Kelly-Scumpia, K.M.3
Moreno, C.4
Scumpia, P.O.5
Laface, D.M.6
Heyworth, P.G.7
Efron, P.A.8
Moldawer, L.L.9
-
19
-
-
10644237032
-
A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis
-
15557347 10.1084/jem.20040708 1:CAS:528:DC%2BD2cXhtVyiurrN
-
S Gibot MN Kolopp-Sarda MC Béné PE Bollaert A Lozniewski F Mory B Levy GC Faure 2004 A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis J Exp Med 200 1419 1426 15557347 10.1084/jem.20040708 1:CAS:528:DC%2BD2cXhtVyiurrN
-
(2004)
J Exp Med
, vol.200
, pp. 1419-1426
-
-
Gibot, S.1
Kolopp-Sarda, M.N.2
Béné, M.C.3
Bollaert, P.E.4
Lozniewski, A.5
Mory, F.6
Levy, B.7
Faure, G.C.8
-
20
-
-
64049095240
-
TREM and TREM-like receptors in inflammation and disease
-
19230638 10.1016/j.coi.2009.01.009 1:CAS:528:DC%2BD1MXksVCntrg%3D
-
JW Ford DW McVicar 2009 TREM and TREM-like receptors in inflammation and disease Curr Opin Immunol 21 38 46 19230638 10.1016/j.coi.2009.01.009 1:CAS:528:DC%2BD1MXksVCntrg%3D
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 38-46
-
-
Ford, J.W.1
McVicar, D.W.2
-
21
-
-
78649586268
-
The biology of myeloid-derived suppressor cells, the blessing and the curse of morphological and functional heterogeneity
-
21061430 10.1002/eji.201040895 1:CAS:528:DC%2BC3cXhtl2isbfK
-
JI Youn DI Gabrilovich 2010 The biology of myeloid-derived suppressor cells, the blessing and the curse of morphological and functional heterogeneity Eur J Immunol 40 2969 2975 21061430 10.1002/eji.201040895 1:CAS:528: DC%2BC3cXhtl2isbfK
-
(2010)
Eur J Immunol
, vol.40
, pp. 2969-2975
-
-
Youn, J.I.1
Gabrilovich, D.I.2
-
22
-
-
35448954376
-
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
-
17942936 10.1158/0008-5472.CAN-07-2354 1:CAS:528:DC%2BD2sXhtFOnsLrF
-
SK Bunt L Yang P Sinha VK Clements J Leips S Ostrand-Rosenberg 2007 Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression Cancer Res 67 10019 10026 17942936 10.1158/0008-5472.CAN-07-2354 1:CAS:528:DC%2BD2sXhtFOnsLrF
-
(2007)
Cancer Res
, vol.67
, pp. 10019-10026
-
-
Bunt, S.K.1
Yang, L.2
Sinha, P.3
Clements, V.K.4
Leips, J.5
Ostrand-Rosenberg, S.6
-
23
-
-
77954399377
-
Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
-
20530204 10.1084/jem.20091474 1:CAS:528:DC%2BC3cXovFaktLY%3D
-
LE Sander SD Sackett U Dierssen N Beraza RP Linke M Müller JM Blander F Tacke C Trautwein 2010 Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function J Exp Med 207 1453 1464 20530204 10.1084/jem.20091474 1:CAS:528:DC%2BC3cXovFaktLY%3D
-
(2010)
J Exp Med
, vol.207
, pp. 1453-1464
-
-
Sander, L.E.1
Sackett, S.D.2
Dierssen, U.3
Beraza, N.4
Linke, R.P.5
Müller, M.6
Blander, J.M.7
Tacke, F.8
Trautwein, C.9
-
24
-
-
76649097628
-
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
-
20093776 1:CAS:528:DC%2BC3cXhsVOktL4%3D
-
F Chalmin S Ladoire G Mignot J Vincent M Bruchard JP Remy-Martin W Boireau A Rouleau B Simon D Lanneau A De Thonel G Multhoff A Hamman F Martin B Chauffert E Solary L Zitvogel C Garrido B Ryffel C Borg L Apetoh C Rébé F Ghiringhelli 2010 Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells J Clin Invest 120 457 471 20093776 1:CAS:528:DC%2BC3cXhsVOktL4%3D
-
(2010)
J Clin Invest
, vol.120
, pp. 457-471
-
-
Chalmin, F.1
Ladoire, S.2
Mignot, G.3
Vincent, J.4
Bruchard, M.5
Remy-Martin, J.P.6
Boireau, W.7
Rouleau, A.8
Simon, B.9
Lanneau, D.10
De Thonel, A.11
Multhoff, G.12
Hamman, A.13
Martin, F.14
Chauffert, B.15
Solary, E.16
Zitvogel, L.17
Garrido, C.18
Ryffel, B.19
Borg, C.20
Apetoh, L.21
Rébé, C.22
Ghiringhelli, F.23
more..
-
25
-
-
1542313914
-
Regulation of TLR signaling and inflammation by SOCS family proteins
-
10.1189/jlb.0403194 1:CAS:528:DC%2BD2cXis1ehsrY%3D
-
A Yoshimura HM Ohishi D Aki T Hanada 2004 Regulation of TLR signaling and inflammation by SOCS family proteins J Leuk Biol 75 422 427 10.1189/jlb.0403194 1:CAS:528:DC%2BD2cXis1ehsrY%3D
-
(2004)
J Leuk Biol
, vol.75
, pp. 422-427
-
-
Yoshimura, A.1
Ohishi, H.M.2
Aki, D.3
Hanada, T.4
-
26
-
-
78651075836
-
Glycogen synthase kinase 3: A point of convergence for the host inflammatory response
-
21095632 10.1016/j.cyto.2010.10.009 1:CAS:528:DC%2BC3MXnsVajtg%3D%3D
-
H Wang J Brown M Martin 2011 Glycogen synthase kinase 3: a point of convergence for the host inflammatory response Cytokine 53 130 140 21095632 10.1016/j.cyto.2010.10.009 1:CAS:528:DC%2BC3MXnsVajtg%3D%3D
-
(2011)
Cytokine
, vol.53
, pp. 130-140
-
-
Wang, H.1
Brown, J.2
Martin, M.3
-
27
-
-
65249138393
-
Myeloid-derived suppressor cells, linking inflammation and cancer
-
19342621 10.4049/jimmunol.0802740 1:CAS:528:DC%2BD1MXjvFOjtrg%3D
-
S Ostrand-Rosenberg P Sinha 2009 Myeloid-derived suppressor cells, linking inflammation and cancer J Immunol 182 4499 4506 19342621 10.4049/jimmunol.0802740 1:CAS:528:DC%2BD1MXjvFOjtrg%3D
-
(2009)
J Immunol
, vol.182
, pp. 4499-4506
-
-
Ostrand-Rosenberg, S.1
Sinha, P.2
-
28
-
-
32044439372
-
CD11b +/Gr-1 + myeloid suppressor cells cause T cell dysfunction after traumatic stress
-
16455964 1:CAS:528:DC%2BD28XpvV2nsg%3D%3D
-
VP Makarenkova V Bansal BM Matta LA Perez JB Ochoa 2006 CD11b +/Gr-1 + myeloid suppressor cells cause T cell dysfunction after traumatic stress J Immunol 176 2085 2094 16455964 1:CAS:528:DC%2BD28XpvV2nsg%3D%3D
-
(2006)
J Immunol
, vol.176
, pp. 2085-2094
-
-
Makarenkova, V.P.1
Bansal, V.2
Matta, B.M.3
Perez, L.A.4
Ochoa, J.B.5
-
29
-
-
60849114014
-
Compensatory anti-inflammatory response syndrome
-
19132187 1:CAS:528:DC%2BD1MXhvVWrtLg%3D
-
M Adib-Conquy JM Cavaillon 2009 Compensatory anti-inflammatory response syndrome Thromb Haemost 101 36 47 19132187 1:CAS:528:DC%2BD1MXhvVWrtLg%3D
-
(2009)
Thromb Haemost
, vol.101
, pp. 36-47
-
-
Adib-Conquy, M.1
Cavaillon, J.M.2
-
30
-
-
78149284668
-
A ribonucleotide reductase inhibitor reverses burn-induced inflammatory defects
-
20386495 10.1097/SHK.0b013e3181e14f78 1:CAS:528:DC%2BC3cXhtlWjsLrF
-
G Noel Q Wang A Osterburg S Schwemberger L James L Haar N Giacalone I Thomas C Ogle 2010 A ribonucleotide reductase inhibitor reverses burn-induced inflammatory defects Shock 34 535 544 20386495 10.1097/SHK.0b013e3181e14f78 1:CAS:528:DC%2BC3cXhtlWjsLrF
-
(2010)
Shock
, vol.34
, pp. 535-544
-
-
Noel, G.1
Wang, Q.2
Osterburg, A.3
Schwemberger, S.4
James, L.5
Haar, L.6
Giacalone, N.7
Thomas, I.8
Ogle, C.9
-
31
-
-
79251537742
-
Sepsis induces early alterations in innate immunity that impact mortality to secondary infection
-
21106855 10.4049/jimmunol.1002104 1:CAS:528:DC%2BC3cXhs1ajtLzL
-
MJ Delano T Thayer S Gabrilovich KM Kelly-Scumpia RD Winfield PO Scumpia AG Cuenca E Warner SM Wallet MA Wallet KA O'Malley R Ramphal M Clare-Salzer PA Efron CE Mathews LL Moldawer 2011 Sepsis induces early alterations in innate immunity that impact mortality to secondary infection J Immunol 186 195 202 21106855 10.4049/jimmunol.1002104 1:CAS:528:DC%2BC3cXhs1ajtLzL
-
(2011)
J Immunol
, vol.186
, pp. 195-202
-
-
Delano, M.J.1
Thayer, T.2
Gabrilovich, S.3
Kelly-Scumpia, K.M.4
Winfield, R.D.5
Scumpia, P.O.6
Cuenca, A.G.7
Warner, E.8
Wallet, S.M.9
Wallet, M.A.10
O'Malley, K.A.11
Ramphal, R.12
Clare-Salzer, M.13
Efron, P.A.14
Mathews, C.E.15
Moldawer, L.L.16
|