Prolonged induced hypothermia in hemorrhagic shock is associated with decreased muscle metabolism: A nuclear magnetic resonance-based metabolomics study

Shock

Volumn 41, Issue 1, 2014, Pages 79-84

  Lusczek, Elizabeth R ^a   Lexcen, Daniel R ^a   Witowski, Nancy E ^a   Determan, Charles ^a   Mulier, Kristine E ^a   Beilman, Greg ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

hemorrhagic shock; Hypothermia; metabolomics

Indexed keywords

AMINO ACID; CREATINE; CREATININE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BATTLE INJURY; COLD EXPOSURE; CONTROLLED STUDY; ENVIRONMENT; HEMORRHAGIC SHOCK; HYPOTHERMIA; INDUCED HYPOTHERMIA; METABOLISM; METABOLOMICS; MUSCLE METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PORCINE MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; RESUSCITATION; SURVIVAL; YORKSHIRE PIG;

AMINO ACIDS; ANIMALS; HYPOTHERMIA, INDUCED; KAPLAN-MEIER ESTIMATE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MILITARY MEDICINE; MUSCLES; SHOCK, HEMORRHAGIC; SUS SCROFA; WOUNDS AND INJURIES;

EID: 84891617746     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000061     Document Type: Article

References (35)

1. Holcomb JB, Stansbury LG, Champion HR, Wade C, Bellamy RF: Understanding combat casualty care statistics. J Trauma 60(2):397-401, 2006.
2. Dubick MA: Current concepts in fluid resuscitation for prehospital care of combat casualties. US Army Med Dep J 2(1):18-24, 2011.
3. Angele MK, Schneider CP, Chaudry IH: Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care 12:218-230, 2008.
4. Cohen MJ, Serkova NJ, Wiener-Kronish J, Pittet JF, Niemann CU: 1H-NMRY based metabolic signatures of clinical outcomes in trauma patients-beyond lactate and base deficit. J Trauma 69(1):31-40, 2010.
5. Sack M: Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance. Cardiovasc Res 72(2):210-219, 2006.
6. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP: A genomic storm in critically injured humans. J Exp Med 208(13):2581-2590, 2011.
7. Committee on Trauma: American College of Surgeons: Advanced Trauma Life Support for Doctors. 5th ed. Chicago, IL: American College of Surgeons, 1997.
8. Martin RS, Kilgo PD, Miller PR, Hoth JJ, Meredith JW, Chang MC: Injuryassociated hypothermia: an analysis of the 2004 National Trauma Data Bank. Shock 24:114-118, 2005.
9. Iyegha UP, Greenberg JJ, Mulier KE, Chipman J, George M, Beilman GJ: Environmental hypothermia in porcine polytrauma and hemorrhagic shock is safe. Shock 38:387-394, 2012.
10. Seekamp A, van Griensven M, Hildebrandt F, Wahlers T, Tscherne H: Adenosinetriphosphate in trauma-related and elective hypothermia. J Trauma 47(4):673-683, 1999.
11. The Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346:549-556, 2002.
12. Nicholson JK, Lindon JC, Holmes E: FMetabonomics-: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11):1181-1189, 1999.
13. Fiehn O: MetabolomicsVthe link between genotypes and phenotypes. Plant Mol Biol 48(1-2):155-171, 2002.
14. Zhang A, Sun H, Wang P, Han Y, Wang X: Modern analytical techniques in metabolomics analysis. Analyst 137(2):293-300, 2012.
15. George ME, Mulier KE, Beilman GJ: Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock. J Trauma 68(3):662-668, 2010.
16. Weljie AM, Newton J, Mercier P, Carlson E, Slupsky CM: Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Anal Chem 78(13): 4430-4442, 2006.
17. Lexcen DR, Lusczek ER, Witowski NE, Mulier KE, Beilman GJ: Metabolomics classifies phase of care and identifies risk for mortality in a porcine model of multiple injuries and hemorrhagic shock. 73:S147-S155, 2012.
18. Liland KH: Multivariate methods in metabolomicsVfrom pre-processing to dimension reduction and statistical analysis. TrAC Trends Anal Chem 30(6): 827-841, 2011.
19. Houtkooper RH, Argmann C, Houten SM, Cantó C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J: The metabolic footprint of aging in mice. Sci Rep 1, article 134, 2011. DOI:10.1038/srep00134.
20. D?́az-Uriarte R, De Andres SA: Gene selection and classification of microarray data using random forest. BMC Bioinform 7(1):3, 2006.
21. Choi JY, Kim SK, Lee WH, Yoo TK, Kim DW: A survival prediction model of rats in hemorrhagic shock using the random forest classifier. Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE, IEEE, pp. 5570-5573, 2012.
22. Xia J, Mandal R, Sinelnikov IV, Broadhurst D, Wishart DS: MetaboAnalyst 2.0Va comprehensive server for metabolomic data analysis. Nucleic Acids Res 40:W127-W133, 2012.
23. R Development Core Team. R: A Language and Environment for Statistical Computing, Reference Index Version 2.15.3. Vienna, Austria: R Foundation for Statistical Computing. Available at: http://www.R-project.org.
24. Chioléro R, Revelly J, Tappy L: Energy metabolism in sepsis and injury. Nutrition 13:45-51, 1997.
25. Askanazi J, Carpentier Y, Michelsen C, Elwyn D, Furst P, Kantrowitz L, Gump F, Kinney J: Muscle and plasma amino acids following injury: influence of intercurrent infection. Ann Surg 192(1):78-85, 1980.
26. Nanobashvili J, Neumayer C, Fügl A, Punz A, Blumer R, Prager M, Mittlböck M, Gruber H, Polterauer P, Roth E: Ischemia/reperfusion injury of skeletal muscle: plasma taurine as a measure of tissue damage. Surgery 133(1):91-100, 2003.
27. Zeiner A, Sunder-Plassmann G, Sterz F, Holzer M, Losert H, Laggner AN, Müllner M: The effect of mild therapeutic hypothermia on renal function after cardiopulmonary resuscitation in men. Resuscitation 60(3): 253-261, 2004.
28. Fukudome EY, Alam HB: Hypothermia in multisystem trauma. Crit Care Med 37(7):S265-S272, 2009.
29. Fugate JE, Brinjikji W, Mandrekar JN, Cloft HJ, White RD, Wijdicks EF, Rabinstein AA: PostYcardiac arrest mortality is declining: a study of the US National Inpatient Sample 2001 to 2009. Circulation 126(5):546-550, 2012.
30. Wu X, Kochanek PM, Cochran K, Nozari A, Henchir J, Stezoski SW, Wagner R, Wisniewski S, Tisherman SA: Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma Acute Care Surg 59(2):291-301, 2005.
31. Blackstone E, Roth MB: Suspended animation-like state protects mice from lethal hypoxia. Shock 27:370-372, 2007.
32. Simon F, Giudici R, Duy CN, Schelzig H, O ̈ ter S, Gröger M, Wachter U, Vogt J, Speit G, Szabo C: Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury. Shock 30:359-364, 2008.
33. Shafi S, Elliott AC, Gentilello L: Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma Acute Care Surg 59(5): 1081-1085, 2005.
34. Sundberg J, Estrada C, Jenkins C, Ray J, Abramo T: Hypothermia is associated with poor outcome in pediatric trauma patients. Am J Emerg Med 29: 1019-1022, 2011.
35. Finkelstein RA, Alam HB: Induced hypothermia for trauma: current research and practice. J Intensive Care Med 25:205-226, 2010