How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study

IEEE Transactions on Biomedical Engineering

Volumn 61, Issue 1, 2014, Pages 35-40

  Teng, Zhongzhao ^a   He, Jing ^a   Sadat, Umar ^b   Mercer, John R ^c   Wang, Xiaoyan ^a,d   Bahaei, Nasim S ^a   Thomas, Owen M ^a   Gillard, Jonathan H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Atherosclerosis; Calcium; Carotid; Stress; Stroke

Indexed keywords

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CAROTID; EXPLORATORY STUDIES; INTER QUARTILE RANGES; MECHANICAL ANALYSIS; STRETCH RATIO; STROKE;

BIOMINERALIZATION; BONE; COMPUTERIZED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING; STRESSES;

CALCIUM;

CALCIUM; IOPAMIDOL;

ADULT; AGED; ARTICLE; BIOMECHANICS; CALCIFICATION; CAROTID ATHEROSCLEROSIS; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; FEMALE; GEOMETRY; HEART CYCLE; HUMAN; JUXTALUMINAL CALCIFICATION; MALE; MECHANICAL STRESS; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; SHEAR STRESS; SIMULATION; VERY ELDERLY;

AGED; ATHEROSCLEROSIS; BIOMECHANICAL PHENOMENA; CALCINOSIS; CALCIUM; CAROTID STENOSIS; HUMANS; MALE; PLAQUE, ATHEROSCLEROTIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84891603360     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2013.2275078     Document Type: Article

References (35)

1. R. M. Kwee, "Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms," J. Vasc. Surg., vol. 51, pp. 1015-1025, 2010.
2. A. Edsfeldt, N. Dias, B. Elmstahl, M. F. Muller, K. Berg, M. Nitulescu, A. Persson, O. Ekberg, and I. Goncalves, "Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques," Stroke, vol. 42, pp. 2966-2969, 2011.
3. C. M. Wahlgren, W. Zheng, W. Shaalan, J. Tang, and H. S. Bassiouny, "Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology," Cerebrovasc. Dis., vol. 27, pp. 193-200, 2009.
4. W. E. Shaalan, H. Cheng, B. Gewertz, J. F. McKinsey, L. B. Schwartz, D. Katz, D. Cao, T. Desai, S. Glagov, and H. S. Bassiouny, "Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation," J. Vasc. Surg., vol. 40, pp. 262-269, 2004. (Pubitemid 39055888)
5. Z. Y. Li, S. Howarth, T. Tang, M. Graves, J. M. U-King-Im, and J. H. Gillard, "Does calcium deposition play a role in the stability of atheroma? Location may be the key," Cerebrovasc. Dis., vol. 24, pp. 452-459, 2007. (Pubitemid 350014971)
6. X. Xu, H. Ju, J. Cai, Y. Cai, X. Wang, and Q. Wang, "High- resolutionMR study of the relationship between superficial calcification and the stability of carotid atherosclerotic plaque," Int. J. Cardiovasc. Imag., vol. 26, Suppl 1, pp. 143-150, 2010.
7. J. M. U-King-Im, T. Y. Tang, A. Patterson, M. J. Graves, S. Howarth, Z. Y. Li, R. Trivedi, D. Bowden, P. J. Kirkpatrick, M. E. Gaunt, E. A. Warburton, N. M. Antoun, and J. H. Gillard, "Characterisation of carotid atheroma in symptomatic and asymptomatic patients using high-resolution MRI," J. Neurol. Neurosurg. Psychiatry, vol. 79, pp. 905-912, 2008.
8. U. Sadat, Z. Y. Li, V. E. Young, M. J. Graves, J. R. Boyle, E. L. Warburton, K. Varty, E. O'Brien, and J. H. Gillard, "Finite element analysis of vulnerable atherosclerotic plaques: A comparison of mechanical stresses within carotid plaques of acute and recently symptomatic patients with carotid artery disease," J. Neurol. Neurosurg. Psychiatry, vol. 81, pp. 286-289, 2009.
9. U. Sadat, R. A. Weerakkody, D. J. Bowden, V. E. Young, M. J. Graves, Z. Y. Li, T. Y. Tang, M. E. Gaunt, P. D. Hayes, and J. H. Gillard, "Utility of high resolution MR imaging to assess carotid plaque morphology: A comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease," Atherosclerosis, vol. 207, pp. 434-439, 2009.
10. C. Zhu, A. J. Patterson, O. M. Thomas, U. Sadat, M. J. Graves, and J. H. Gillard, "Carotid stenosis assessmentwith multi-detectorCT angiography: Comparison between manual and automatic segmentation methods," Int J. Cardiovasc Imag., vol. 29, pp. 899-905, 2012.
11. D. Tang, Z. Teng, G. Canton, C. Yang, M. Ferguson, X. Huang, J. Zheng, P. K. Woodard, and C. Yuan, "Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: An in vivo MRI-based 3D fluid-structure interaction study," Stroke, vol. 40, pp. 3258-3263, 2009.
12. G. A. Holzapfel, G. Sommer, C. T. Gasser, and P. Regitnig, "Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling," Amer. J. Physiol. Heart Circ. Physiol., vol. 289, pp. H2048-H2058, 2005. (Pubitemid 41507356)
13. G. A. Holzapfel, C. A. J. Schulze-Bauer, and M. Stadler, Mechanics of Angioplasty: Wall, Balloon and Stent. vol. AMD-242. New York, NY, USA: ASME, 2000.
14. J. D. Humphery, Cardiovascular Solid Mechanics. New York, NY, USA: Springer-Verlag, 2002.
15. S. Kobayashi, D. Tsunoda, Y. Fukuzawa, H. Morikawa, D. Tang, and D. N. Ku, "Flow and compression in arterial models of stenosis with lipid core," presented at the ASME Summer Bioengineering Conf., Miami, FL, USA, 2003.
16. H. Xie, K. Kim, S. R. Aglyamov, S. Y. Emelianov, M. O'Donnell, W. F. Weitzel, S. K. Wrobleski, D. D. Myers, T.W. Wakefield, and J. M. Rubin, "Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats," Ultrasound Med. Biol., vol. 31, pp. 1351-1359, 2005. (Pubitemid 41434051)
17. H. Xie, K. Kim, S. R. Aglyamov, S.Y. Emelianov, X. Chen, M. O'Donnell, W. F. Weitzel, S. K. Wrobleski, D. D. Myers, T. W. Wakefield, and J. M. Rubin, "Staging deep venous thrombosis using ultrasound elasticity imaging: Animal model," Ultrasound Med. Biol., vol. 30, pp. 1385-1396, 2004. (Pubitemid 39576191)
18. J. M. Rubin, H. Xie, K. Kim, W. F. Weitzel, S. Y. Emelianov, S. R. Aglyamov, T. W. Wakefield, A. G. Urquhart, and M. O'Donnell, "Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans," J. Ultrasound Med., vol. 25, pp. 1179-1186, 2006. (Pubitemid 44316265)
19. J. M. Rubin, S. R. Aglyamov, T. W. Wakefield, M. O'Donnell, and S. Y. Emelianov, "Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis: Preliminary findings," J. Ultrasound Med., vol. 22, pp. 443-448, 2003. (Pubitemid 36528746)
20. K. J. Bathe, Finite Element Procedures. Englewood Cliffs, NJ, USA: Prentice-Hall, 1996.
21. H. M. Loree, A. J. Grodzinsky, S. Y. Park, L. J. Gibson, and R. T. Lee, "Static circumferential tangential modulus of human atherosclerotic tissue," J. Biomech., vol. 27, pp. 195-204, 1994. (Pubitemid 24030793)
22. Y. Vengrenyuk, S. Carlier, S. Xanthos et al., "A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps," Proc. Natl. Acad. Sci. U S A., vol. 103, pp. 14678-14683, 2006. (Pubitemid 44527789)
23. D. Bluestein, Y. Alemu, I. Avrahami, M. Gharib, K. Dumont, J. J. Ricotta, and S. Einav, "Influence of microcalcifications on vulnerable plaque mechanics using FSI modeling," J. Biomech., vol. 41, pp. 1111-1118, 2008.
24. J. F. Wenk, P. Papadopoulos, and T. I. Zohdi, "Numerical modeling of stress in stenotic arteries with microcalcifications: A micromechanical approximation," J. Biomech. Eng., vol. 132, p. 091011, 2010.
25. H. Huang, R. Virmani, H. Younis, A. P. Burke, R. D. Kamm, and R. T. Lee, "The impact of calcification on the biomechanical stability of atherosclerotic plaques," Circulation, vol. 103, pp. 1051-1056, 2001. (Pubitemid 32200176)
26. K. K. Wong, P. Thavornpattanapong, S. C. Cheung, Z. Sun, and J. Tu, "Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model," BMC Cardiovasc. Disord., vol. 12, p. 7, 2012.
27. N. Alexopoulos and P. Raggi, "Calcification in atherosclerosis, " Nat. Rev. Cardiol., vol. 6, pp. 681-688, 2009.
28. D. Proudfoot J. N. Skepper, L. Hegyi, M. R. Bennett, C. M. Shanahan, and P. L. Weissberg, "Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic bodies," Circ. Res., vol. 87, pp. 1055-1062, 2000.
29. K. L. Tyson, J. L. Reynolds, R. McNair, Q. Zhang, P. L. Weissberg, and C. M. Shanahan, "Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification," Arterioscler. Thromb. Vasc. Biol., vol. 23, pp. 489-494, 2003. (Pubitemid 36337227)
30. C. Cola, M. Almeida, D. Li, F. Romeo, and J. L. Mehta, "Regulatory role of endothelium in the expression of genes affecting arterial calcification," Biochem. Biophys. Res. Commun., vol. 320, pp. 424-427, 2004. (Pubitemid 38798884)
31. R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, "Lessons from sudden coronary death: A comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol., vol. 20, pp. 1262-1275, 2000. (Pubitemid 30262927)
32. V. Chandran, A. Pai, and S. Rao, "Calcified embolism: A rare cause of cerebral infarction," BMJ Case Rep. 2013, 2013.
33. Y. C. Fung, "What are the residual stresses doing in our blood vessels?" Ann. Biomed. Eng., vol. 19, pp. 237-249, 1991.
34. L. Speelman, A. C. Akyildiz, B. den Adel, J. J. Wentzel, A. F. van der Steen, R. Virmani, L. van der Weerd, J.W. Jukema, R. E. Poelmann, E. H. van Brummelen, and F. J. Gijsen, "Initial stress in biomechanical models of atherosclerotic plaques," J. Biomech., vol. 44, pp. 2376-2382, 2011.
35. J. Ohayon, O. Dubreuil, P. Tracqui, S. Le Floc'h, G. Rioufol, L. Chalabreysse, F. Thivolet, R. I. Pettigrew, and G. Finet, "Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: Potential impact for evaluating the risk of plaque rupture," Amer. J. Physiol. Heart Circ. Physiol., vol. 293, pp. H1987-H1996, 2007. (Pubitemid 47370971)