Ubiquitin-conjugating enzyme E2C: A potential cancer biomarker

International Journal of Biochemistry and Cell Biology

Volumn 47, Issue 1, 2014, Pages 113-117

  Xie, Chanlu ^a   Powell, Chris ^a   Yao, Mu ^b   Wu, Jianmin ^c,d   Dong, Qihan ^a,b  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Anaphase promoting complex; Cancer; Ubiquitin conjugating enzymes 2C; Ubiquitination

Indexed keywords

BIOLOGICAL MARKER; TUMOR MARKER; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME 2C; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANEUPLOIDY; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONJUGATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME METABOLISM; ENZYME STRUCTURE; HUMAN; M PHASE CELL CYCLE CHECKPOINT; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

3(10); 3(10)-HELIX; ALL-TRANS RETINOIC ACID; AMINO ACID-TERMINAL; ANAPHASE-PROMOTING COMPLEX; ANAPHASE-PROMOTING COMPLEX/CYCLOSOME; APC/C; ATRA; AVIAN MYELOCYTOMATOSIS VIRUS ONCOGENE CELLULAR HOMOLOG; B1-4; BUB RECEPTOR 1; BUB3; BUBR1; BUDDING UNINHIBITED BY BENZIMIDAZOLES 3; C-MYC; C-REL; CADHERIN-1; CALPAIN-1 A/C; CANCER; CCI-779; CDC20; CDH1; CDK; CELL CYCLE INHIBITOR-779; CELL DIVISION CYCLE 20; CP1A/C; CYCLIN-DEPENDENT KINASE; D-BOX; DESTRUCTION BOX; DEUBIQUITINATION ENZYMES; DOMAIN, DOMAIN FIND IN RING FINGER-WD REPEAT DOMAIN CONTAINING PROTEIN; DUBS; E1; E2; E2F; E3; ELONGATION 2 TRANSCRIPTION FACTOR; FINGER DOMAIN, REALLY INTERESTING NEW GENE FINGER DOMAIN; G(1); G(2); GAP 1 PHASE; GAP 2 PHASE; H1-4; HUMAN UBIQUITIN-CONJUGATING ENZYME 10; JNK; JUN N-TERMINAL KINASES; KEN-BOX; M; MAD 2; MED1; MEDIATOR-1; MEIS-1; MESSENGER RIBONUCLEIC ACID; MITOSIS PHASE; MITOTIC ARREST DEFICIENT-LIKE 2; MOTIF, GLN(4), ASN(5) AND PRO(8) MOTIF; MRNA; MYELOID ECOTROPIC VIRAL INTEGRATION SITE 1; N-TERMINAL; NEUROFIBROMIN 1; NF-1; NIH3T3; PAX-2; PAXILLIN 2; PRIMARY MOUSE EMBRYONIC FIBROBLAST; QNP; RETICULOENDOTHELIOSIS ONCOGENE CELLULAR HOMOLOG; RING; RWD; S; S-PHASE KINASE-ASSOCIATED PROTEIN 2; SCF; SERUM RESPONSE FACTOR; SKP1-CULLIN-FOX COMPLEX; SKP2; SRF; SYNTHESIS PHASE; THE AMINO ACID SEQUENCE KEN(X)(N)P; UBCH10; UBE2C; UBIQUITIN LIGASE; UBIQUITIN PROTEASOME SYSTEM; UBIQUITIN SPECIFIC PEPTIDASE 44; UBIQUITIN-ACTIVATING ENZYME; UBIQUITIN-CONJUGATING ENZYME; UBIQUITIN-CONJUGATING ENZYME E2; UBIQUITIN-CONJUGATING ENZYMES 2C; UBIQUITINATION; UPS; USP44; Α-HELICES; Β-SHEETS;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; UBIQUITIN-CONJUGATING ENZYMES;

EID: 84891585988     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.11.023     Document Type: Short Survey

References (29)

1. A. Aristarkhov, E. Eytan, A. Moghe, A. Admon, A. Hershko, and J.V. Ruderman E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins Proceedings of the National Academy of Sciences of the United States of America 93 9 1996 4294 4299 10.1038/nrm2780 (Pubitemid 26144279)
2. A. Arvand, H. Bastians, S.M. Welford, A.D. Thompson, J.V. Ruderman, and C.T. Denny EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction Oncogene 17 16 1998 2039 2045 10.1038/sj.onc.1202129 (Pubitemid 28499330)
3. Z. Chen, C. Zhang, D. Wu, H. Chen, A. Rorick, and X. Zhang et al. Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth The EMBO Journal 30 12 2011 2405 2419 10.1038/emboj.2011.154
4. R. Grutzmann, C. Pilarsky, O. Ammerpohl, J. Luttges, A. Bohme, and B. Sipos et al. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays Neoplasia (New York) 6 5 2004 611 622 10.1593/neo.04295 (Pubitemid 39411099)
5. Z. Hao, H. Zhang, and J. Cowell Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 33 3 2012 723 730 10.1007/s13277-011-0291-1
6. F. Jiang, and R. Basavappa Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution Biochemistry 38 20 1999 6471 6478 10.1021/bi9901329 (Pubitemid 29242040)
7. L. Jin, A. Williamson, S. Banerjee, I. Philipp, and M. Rape Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex Cell 133 4 2008 653 665 10.1016/j.cell.2008.04.012 (Pubitemid 351636306)
8. Y. Lin, W.C. Hwang, and R. Basavappa Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10 Journal of Biological Chemistry 277 24 2002 21913 21921 10.1074/jbc.M109398200 (Pubitemid 34952345)
9. J. Lu, M. Wen, Y. Huang, X. He, Y. Wang, and Q. Wu et al. C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes Epigenetics: Official Journal of the DNA Methylation Society 8 6 2013 10.4161/epi.24626
10. H.J. Meyer, and M. Rape Processive ubiquitin chain formation by the anaphase-promoting complex Seminars in Cell & Developmental Biology 22 6 2011 544 550 10.1016/j.semcdb.2011.03.009
11. O. Nagy, M. Pal, A. Udvardy, C.A. Shirras, I. Boros, and A.D. Shirras et al. lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2 Cell Division 7 1 2012 9 10.1186/1747-1028-7-9
12. N. Nameki, M. Yoneyama, S. Koshiba, N. Tochio, M. Inoue, and E. Seki et al. Solution structure of the RWD domain of the mouse GCN2 protein Protein Science: A Publication of the Protein Society 13 8 2004 2089 2100 10.1110/ps.04751804 (Pubitemid 38989613)
13. S. Nath, T. Banerjee, D. Sen, T. Das, and S. Roychoudhury Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10 Journal of Biological Chemistry 286 18 2011 15666 15677 10.1074/jbc.M110.160671
14. Y. Okamoto, T. Ozaki, K. Miyazaki, M. Aoyama, M. Miyazaki, and A. Nakagawara UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme Cancer Research 63 14 2003 4167 4173 (Pubitemid 36917942)
15. S.K. Olsen, and C.D. Lima Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer Molecular Cell 49 5 2013 884 896 10.1016/j.molcel.2013.01.013
16. M. Rape, and M.W. Kirschner Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry Nature 432 7017 2004 588 595 10.1038/nature03023 (Pubitemid 39626259)
17. M. Rape, S.K. Reddy, and M.W. Kirschner The processivity of multiubiquitination by the APC determines the order of substrate degradation Cell 124 1 2006 89 103 10.1016/j.cell.2005.10.032 (Pubitemid 43069312)
18. S.K. Reddy, M. Rape, W.A. Margansky, and M.W. Kirschner Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation Nature 446 7138 2007 921 925 10.1038/nature05734 (Pubitemid 46633168)
19. M.K. Summers, B. Pan, K. Mukhyala, and P.K. Jackson The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC Molecular Cell 31 4 2008 544 556 10.1016/j.molcel.2008.07.014
20. F.M. Townsley, A. Aristarkhov, S. Beck, A. Hershko, and J.V. Ruderman Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase Proceedings of the National Academy of Sciences of the United States of America 94 6 1997 2362 2367 10.1073/pnas.94.6.2362 (Pubitemid 27136880)
21. J.H. van Ree, K.B. Jeganathan, L. Malureanu, and J.M. van Deursen Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation The Journal of Cell Biology 188 1 2010 83 100 10.1083/jcb.200906147
22. A. Vasiljevic, J. Champier, D. Figarella-Branger, A. Wierinckx, A. Jouvet, and M. Fevre-Montange Molecular characterization of central neurocytomas: potential markers for tumor typing and progression Neuropathology: Official Journal of the Japanese Society of Neuropathology 33 2 2013 149 161 10.1111/j.1440-1789.2012.01338.x
23. A. Walker, C. Acquaviva, T. Matsusaka, L. Koop, and J. Pines UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator Journal of Cell Science 121 Pt 14 2008 2319 2326 10.1242/jcs.031591
24. H. Wang, C. Zhang, A. Rorick, D. Wu, M. Chiu, and J. Thomas-Ahner et al. CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability Cancer Research 71 14 2011 4866 4876 10.1158/0008-5472.CAN-10- 4576
25. S. Wang, J.C. Rijk, M.J. Pen, J.M. Aarts, A.A. Peijnenburg, and I.M. Rietjens et al. A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies Analytical Biochemistry 435 1 2013 83 92 10.1016/j.ab.2012.12.016
26. A. Williamson, S. Banerjee, X. Zhu, I. Philipp, A.T. Iavarone, and M. Rape Regulation of ubiquitin chain initiation to control the timing of substrate degradation Molecular Cell 42 6 2011 744 757 10.1016/j.molcel.2011.04.022
27. S.S. Wing, and P. Jain Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis The Biochemical Journal 305 Pt 1 1995 125 132 10.1006/dbio.1999.9342
28. Y. Ye, and M. Rape Building ubiquitin chains: E2 enzymes at work Nature Reviews. Molecular Cell Biology 10 11 2009 755 764 10.1038/nrm2780
29. M. Zhao, N.-Y. Zhang, A. Zurawel, K.C. Hansen, and C.-W. Liu Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates Journal of Biological Chemistry 285 7 2010 4771 4780 10.1074/jbc.M109.060095