Experience with lexicomp® online drug database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients

Journal of Analytical Oncology

Volumn 1, Issue 1, 2012, Pages 32-41

  Pottel, Lies ^a   Lycke, Michelle ^a   Boterberg, Tom ^b   Ketelaars, Lore ^a   Pottel, Hans ^c   Goethals, Laurence ^a   Van den Noortgate, Nele ^b   Duprez, Fréderic ^b   De Neve, Wilfried ^b   Rottey, Sylvie ^d   Geldhof, Kurt ^e   Van Eygen, Koen ^f   Kargar Samani, Khalil ^g   Ghekiere, Véronique ^a   Verhaeghe, Anne ^a   Debruyne, Philip R ^a  

^a General Hospital Groeninge   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e Jan Yperman Hospital   (Belgium)

^f Department of Medicine   (Belgium)

^g Department of Nephrology   (Belgium)

Author keywords

Cancer treatment; Comprehensive geriatric assessment; Drug drug interactions; Elderly cancer patients; Lexicomp online drug database; Polypharmacy; Safe prescription behavior

Indexed keywords

EID: 84891557851     PISSN: 19277210     EISSN: 19277229     Source Type: Journal    
DOI: 10.6000/1927-7229.2012.01.01.5     Document Type: Article

References (28)

1. Yancik R. Cancer burden in the aged: an epidemiologic and demographic overview. Cancer 1997; 80(7): 1273-83. http://dx.doi.org/10.1002/(SICI)1097-0142(19971001)80:7<1273::AID-CNCR13>3.0.CO;2-4
2. Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457-65.
3. Corcoran ME. Polypharmacy in the Older Patient With Cancer. Cancer Control 1997; 4(5): 419-28.
4. Wright RM, Warpula RW. Geriatric pharmacology: safer prescribing for the elderly patient. J Am Podiatr Med Assoc 2004; 94(2): 90-7.
5. Sokol KC, Knudsen JF, Li MM. Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management. J Clin Pharm Ther 2007; 32(2): 169-75. http://dx.doi.org/10.1111/j.1365-2710.2007.00815.x
6. Chen CC, Kenefick AL, Tang ST, McCorkle R. Utilization of comprehensive geriatric assessment in cancer patients. Crit Rev Oncol Hematol 2004; 49(1): 53-67. http://dx.doi.org/10.1016/S1040-8428(03)00098-2
7. Blower P, de Wit R, Goodin S, Aapro M. Drug-drug interactions in oncology: why are they important and can they be minimized? Crit Rev Oncol Hematol 2005; 55(2): 117-42. http://dx.doi.org/10.1016/j.critrevonc.2005.03.007
8. Extermann M, Aapro M, Bernabei R, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 2005; 55(3): 241-52. http://dx.doi.org/10.1016/j.critrevonc.2005.06.003
9. Clauson KA, Marsh WA, Polen HH, Seamon MJ, Ortiz BI. Clinical decision support tools: analysis of online drug information databases. BMC Med Inform Decis Mak 2007; 7: 7. http://dx.doi.org/10.1186/1472-6947-7-7
10. Polen HH, Zapantis A, Clauson KA, Jebrock J, Paris M. Ability of online drug databases to assist in clinical decisionmaking with infectious disease therapies. BMC Infect Dis 2008; 8: 153. http://dx.doi.org/10.1186/1471-2334-8-153
11. Pottel L, Boterberg T, Pottel H, et al. Determination of an adequate screening tool for identification of vulnerable elderly head and neck cancer patients treated with radio(chemo)therapy. J Geriatr Oncol 2012; 3(1): 24-32. http://dx.doi.org/10.1016/j.jgo.2011.11.006
12. Bellera CA, Rainfray M, Mathoulin-Pelissier S, et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol 2012; 16.
13. Saliba D, Elliott M, Rubenstein LZ, et al. The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc 2001; 49(12): 1691-9. http://dx.doi.org/10.1046/j.1532-5415.2001.49281.x
14. Belgian Center for Pharmacotherapeutic Information (Belgisch Centrum voor Farmacotherapeutische Informatie, B.C.F.I. VZW). Available from: http: //www.bcfi.be; http: //www.cbip.be.
15. Gecommentarieerd Geneesmiddelenrepertorium. 22ste editie; D/2008/0435/1 ed: Belgisch Centrum voor Farmacotherapeutische Informatie (BCFI); 2009.
16. Lexicomp® interaction analyser (Lexicomp® Inc., Ohio, USA). [cited 2010 - 2012]; Available from: http://www.uptodate.com
17. Extermann M. Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 2000; 35(3): 181-200. http://dx.doi.org/10.1016/S1040-8428(00)00090-1
18. Kruse AL, Bredell M, Luebbers HT, Gratz KW. Head and neck cancer in the elderly: a retrospective study over 10 years (1999 - 2008). Head Neck Oncol. 2010, 2:25.
19. Freyer G, Geay JF, Touzet S, et al. Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study. Ann Oncol 2005; 16(11): 1795-800. http://dx.doi.org/10.1093/annonc/mdi368
20. Wildiers H. Mastering chemotherapy dose reduction in elderly cancer patients. Eur J Cancer 2007; 43(15): 2235-41. http://dx.doi.org/10.1016/j.ejca.2007.06.013
21. Davis MP, Homsi J. The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine. Support Care Cancer 2001; 9(6): 442-51. http://dx.doi.org/10.1007/s005200000222
22. Chutka DS, Evans JM, Fleming KC, Mikkelson KG. Symposium on geriatrics--Part I: Drug prescribing for elderly patients. Mayo Clin Proc 1995; 70(7): 685-93. http://dx.doi.org/10.4065/70.7.685
23. Giron MS, Wang HX, Bernsten C, Thorslund M, Winblad B, Fastbom J. The appropriateness of drug use in an older nondemented and demented population. J Am Geriatr Soc 2001; 49(3): 277-83. http://dx.doi.org/10.1046/j.1532-5415.2001.4930277.x
24. Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998; 279(15): 1200-5. http://dx.doi.org/10.1001/jama.279.15.1200
25. Rivkin A, Yin H. Evaluation of the role of the critical care pharmacist in identifying and avoiding or minimizing significant drug-drug interactions in medical intensive care patients. J Crit Care. 2011;26(1):104.e1-6. Epub 2010 Jun 19.
26. Karas S Jr. The potential for drug interactions. Ann Emerg Med 1981; 10(12): 627-30. http://dx.doi.org/10.1016/S0196-0644(81)80085-6
27. Knight EL, Avorn J. Quality indicators for appropriate medication use in vulnerable elders. Ann Intern Med 2001; 135(8 Pt 2): 703-10.
28. Shekelle PG, MacLean CH, Morton SC, Wenger NS. Acove quality indicators. Ann Intern Med 2001; 135(8 Pt 2): 653-67.