A microfluidic device with 3-D hydrogel villi scaffold to simulate intestinal absorption

Journal of Nanoscience and Nanotechnology

Volumn 13, Issue 11, 2013, Pages 7220-7228

  Kim, Si Hyeon ^a   Lee, Jung Woo ^a   Choi, Inwook ^b   Kim, Young Chan ^b   Lee, Jong Bum ^c   Sung, Jong Hwan ^a  

^a Hong Ik University   (South Korea)

^b Korea Food Research Institute   (South Korea)

^c University of Seoul   (South Korea)

Author keywords

3 D hydrogel scaffold; Gastrointestinal absorption; Microfluidic

Indexed keywords

GASTROINTESTINAL ABSORPTIONS; HIGH THROUGHPUT IMPLEMENTATION; HYDROGEL SCAFFOLDS; INTESTINAL ABSORPTION; MICRO-FABRICATION TECHNIQUES; MICRO-FLUIDIC DEVICES; PHYSIOLOGICAL ENVIRONMENT; THREE DIMENSIONAL GEOMETRY;

CELL CULTURE; FLUIDIC DEVICES; HYDROGELS; KINETICS; MICROFLUIDICS; PHYSIOLOGY;

THREE DIMENSIONAL;

BIOMIMETIC MATERIAL; TISSUE SCAFFOLD; HYDROGEL;

ARTICLE; BIOASSAY; BIOMIMETICS; CELL STRAIN CACO 2; CHEMISTRY; DIFFUSION; DRUG SCREENING; EQUIPMENT; EQUIPMENT DESIGN; EQUIPMENT FAILURE; FLOW INJECTION ANALYSIS; HUMAN; HYDROGEL; INTESTINE ABSORPTION; MATERIALS TESTING; METHODOLOGY; MICROFLUIDIC ANALYSIS; PHYSIOLOGY; SYNTHESIS; CACO 2 CELL LINE; DEVICE FAILURE ANALYSIS; DEVICES; PROCEDURES; TISSUE SCAFFOLD;

BIOLOGICAL ASSAY; BIOMIMETIC MATERIALS; BIOMIMETICS; CACO-2 CELLS; DIFFUSION; DRUG EVALUATION, PRECLINICAL; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FLOW INJECTION ANALYSIS; HUMANS; HYDROGELS; INTESTINAL ABSORPTION; MATERIALS TESTING; MICROFLUIDIC ANALYTICAL TECHNIQUES; TISSUE SCAFFOLDS;

EID: 84891536845     PISSN: 15334880     EISSN: 15334899     Source Type: Journal    
DOI: 10.1166/jnn.2013.8088     Document Type: Article

References (29)

1. H. H. Salman, C. Gamazo, M. A. Campanero, and J. M. Irache, J. Nanosci. Nanotechnol. 6, 3203 (2006).
2. K. S. Pang, Drug. Metab. Dispos. 31, 1507 (2003).
3. X. Y. Xiong, K. C. Tam, and L. H. Gan, J. Nanosci. Nanotechnol. 6, 2638 (2006).
4. P. Artursson, K. Palm, and K. Luthman, Adv. Drug. Deliv. Rev. 46, 27 (2001).
5. M. Yoshioka, R. H. Erickson, H. Matsumoto, E. Gum, and Y. S. Kim, Int. J. Cancer 47, 916 (1991).
6. L. Wang, S. K. Murthy, G. A. Barabino, and R. L. Carrier, Biomaterials 31, 7586 (2010).
7. N. T. Elliott and F. Yuan, J. Pharm. Sci. 100, 59 (2011).
8. J. H. Sung, J. Yu, D. Luo, M. L. Shuler, and J. C. March, Lab Chip 11, 389 (2011).
9. J. Yu, S. Peng, D. Luo, and J. C. March, Biotechnol. Bioeng. 109, 2173 (2012).
10. H. J. Kim, D. Huh, G. Hamilton, and D. E. Ingber, Lab Chip 12, 2165 (2012).
11. V. L. Cross, Y. Zheng, N. Won Choi, S. S. Verbridge, B. A. Sutermaster, L. J. Bonassar, C. Fischbach, and A. D. Stroock, Biomaterials 31, 8596 (2010).
12. P. Morier, C. Vollet, P. E. Michel, F. Reymond, and J. S. Rossier, Electrophoresis 25, 3761 (2004).
13. J. H. Sung, C. Kam, and M. L. Shuler, Lab Chip 10, 446 (2010).
14. I. Meyvantsson, J. W. Warrick, S. Hayes, A. Skoien, and D. J. Beebe, Lab Chip 8, 717 (2008).
15. A. Gutzeit, M. A. Patak, C. von Weymarn, N. Graf, A. Doert, E. Willemse, C. A. Binkert, and J. M. Froehlich, J. Magn. Reson. Imaging 32, 345 (2010).
16. B. Davies and T. Morris, Pharm. Res. 10, 1093 (1993).
17. M. P. Cuchiara, A. C. Allen, T. M. Chen, J. S. Miller, and J. L. West, Biomaterials 31, 5491 (2010).
18. P. Galambos and F. Forster, Proceedings from the -TAS '98 Workshop, Springer, Netherlands (1998), p. 189.
19. J. H. Yeon and J. K. Park, Anal. Chem. 81, 1944 (2009).
20. I. Hubatsch, E. G. Ragnarsson, and P. Artursson, Nat. Protoc. 2, 2111 (2007).
21. M. Bermejo, A. Avdeef, A. Ruiz, R. Nalda, J. A. Ruell, O. Tsinman, I. Gonzalez, C. Fernandez, G. Sanchez, T. M. Garrigues, and V. Merino, Eur. J. Pharm. Sci. 21, 429 (2004).
22. I. J. Hidalgo, T. J. Raub, and R. T. Borchardt, Gastroenterology 96, 736 (1989).
23. A. Avdeef, P. E. Nielsen, and O. Tsinman, Eur. J. Pharm. Sci. 22, 365 (2004).
24. M. Dhayal, C. So, J. S. Choi, and J. Jun, J. Nanosci. Nanotechnol. 6, 3494 (2006).
25. E. E. Chiellini, F. Chiellini, and R. Solaro, J. Nanosci. Nanotechnol. 6, 3040 (2006).
26. B. H. Chueh, D. Huh, C. R. Kyrtsos, T. Houssin, N. Futai, and S. Takayama, Anal. Chem. 79, 3504 (2007).
27. C. Ramello, P. Paullier, A. Ould-Dris, M. Monge, C. Legallais, and E. Leclerc, Toxicol. In Vitro 25, 1123 (2011).
28. A. Ould-Dris, P. Paullier, L. Griscom, C. Legallais, and E. Leclerc, J. Memb. Sci. 352, 116 (2010).
29. N. W. Choi, M. Cabodi, B. Held, J. P. Gleghorn, L. J. Bonassar, and A. D. Stroock, Nat. Mater. 6, 908 (2007).