Mouse strain differences in metabolic fluxes and function of ex vivo working hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 1, 2014, Pages

  Vaillant, Fanny ^a   Lauzier, Benjamin ^a   Poirier, Isabelle ^a   Gélinas, Roselle ^a   Rivard, Marie Eve ^a   Robillard Frayne, Isabelle ^a   Thorin, Eric ^a   Des Rosiers, Christine ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Function; Genetic background; Isolated working heart; Metabolism

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE I; GLUCOSE; GLUCOSE TRANSPORTER 4; LACTATE DEHYDROGENASE; MALONYL COENZYME A; TRIACYLGLYCEROL;

129S6/SVEVTAC MOUSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; C57BL/6NCRL MOUSE; CARBOXYLATION; CONTROLLED STUDY; DECARBOXYLATION; ENERGY METABOLISM; EX VIVO STUDY; GLYCOLYSIS; HEART CYCLE; HEART FUNCTION; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEART WORK; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SJL/JCRNTAC MOUSE; TRANSGENIC MOUSE;

EID: 84891532334     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00465.2013     Document Type: Article

References (46)

1. Aasum E, Lathrop DA, Henden T, Sundset R, Larsen TS. The role of glycolysis in myocardial calcium control. J Mol Cell Cardiol 30: 1703-1712, 1998.
2. Ardehali H, Sabbah HN, Burke MA, Sarma S, Liu PP, Cleland JG, Maggioni A, Fonarow GC, Abel ED, Campia U, Gheorghiade M. Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail 14: 120-129, 2012.
3. Barnabei MS, Palpant NJ, Metzger JM. Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains. Physiol Genomics 42A: 103-113, 2010.
4. Barrick CJ, Rojas M, Schoonhoven R, Smyth SS, Threadgill DW. Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal-and background-dependent development of concentric left ventricular hypertrophy. Am J Physiol Heart Circ Physiol 292: H2119-H2130, 2007.
5. Bendall JK, Heymes C, Wright TJ, Wheatcroft S, Grieve DJ, Shah AM, Cave AC. Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. J Mol Cell Cardiol 34: 1325-1333, 2002.
6. Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 57: 1790-1799, 2008.
7. Berthonneche C, Peter B, Schupfer F, Hayoz P, Kutalik Z, Abriel H, Pedrazzini T, Beckmann JS, Bergmann S, Maurer F. Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS One 4: e6610, 2009.
8. Boardman NT, Larsen TS, Severson DL, Essop MF, Aasum E. Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. Am J Physiol Heart Circ Physiol 300: H1631-H1636, 2011.
9. Broberg CS, Pantely GA, Barber BJ, Mack GK, Lee K, Thigpen T, Davis LE, Sahn D, Hohimer AR. Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function. J Am Soc Echocardiogr 16: 814-823, 2003.
10. Busseuil D, Shi Y, Mecteau M, Brand G, Gillis MA, Thorin E, Asselin C, Romeo P, Leung TK, Latour JG, Des Rosiers C, Bouly M, Rheaume E, Tardif JC. Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis. Cardiology 117: 234-242, 2011.
11. Cook SA, Clerk A, Sugden PH. Are transgenic mice the alkahest to understanding myocardial hypertrophy and failure? J Mol Cell Cardiol 46: 118-129, 2009.
12. Dansky HM, Charlton SA, Sikes JL, Heath SC, Simantov R, Levin LF, Shu P, Moore KJ, Breslow JL, Smith JD. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19: 1960-1968, 1999.
13. Dunn ME, Manfredi TG, Cosmas AC, Vetter FJ, King JN, Rodgers RL. Mechanical function, glycolysis, and ultrastructure of perfused working mouse hearts following thoracic aortic constriction. Cardiovasc Pathol 20: 343-351, 2011.
14. Dyck JR, Lopaschuk GD. AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol 574: 95-112, 2006.
15. Esworthy RS, Smith DD, Chu FF. A strong impact of genetic background on gut microflora in mice. Int J Inflam 2010: 986046, 2010.
16. Garcia-Menendez L, Karamanlidis G, Kolwicz S, Tian R. Substrain specific response to cardiac pressure overload in C57BL/6 mice. Am J Physiol Heart Circ Physiol 305: H397-H402, 2013.
17. Gelinas R, Labarthe F, Bouchard B, Mc Duff J, Charron G, Young ME, Des Rosiers C. Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts. Am J Physiol Heart Circ Physiol 294: H1571-H1580, 2008.
18. Gelinas R, Thompson-Legault J, Bouchard B, Daneault C, Mansour A, Gillis MA, Charron G, Gavino V, Labarthe F, Des Rosiers C. Prolonged QT interval and lipid alterations beyond-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts. Am J Physiol Heart Circ Physiol 301: H813-H823, 2011.
19. Glatz JF, Luiken JJ, Bonen A. Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. Physiol Rev 90: 367-417, 2010.
20. Hafstad AD, Khalid AM, Hagve M, Lund T, Larsen TS, Severson DL, Clarke K, Berge RK, Aasum E. Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovasc Res 83: 519-526, 2009.
21. Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145: 3258-3264, 2004.
22. Hoit BD, Kiatchoosakun S, Restivo J, Kirkpatrick D, Olszens K, Shao H, Pao YH, Nadeau JH. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics 79: 679-685, 2002.
23. Hue L, Beauloye C, Marsin AS, Bertrand L, Horman S, Rider MH. Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways. J Mol Cell Cardiol 34: 1091-1097, 2002.
24. Kassiotis C, Rajabi M, Taegtmeyer H. Metabolic reserve of the heart: the forgotten link between contraction and coronary flow. Prog Cardiovasc Dis 51: 74-88, 2008.
25. Khairallah M, Khairallah R, Young ME, Dyck JR, Petrof BJ, Des Rosiers C. Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathy. J Mol Cell Cardiol 43: 119-129, 2007.
26. Khairallah M, Labarthe F, Bouchard B, Danialou G, Petrof BJ, Des Rosiers C. Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons. Am J Physiol Heart Circ Physiol 286: H1461-H1470, 2004.
27. Khairallah RJ, Khairallah M, Gelinas R, Bouchard B, Young ME, Allen BG, Lopaschuk GD, Deschepper CF, Des Rosiers C. Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation. J Mol Cell Cardiol 45: 230-239, 2008.
28. Korvald C, Elvenes OP, Myrmel T. Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol 278: H1345-H1351, 2000.
29. Lauzier B, Merlen C, Vaillant F, McDuff J, Bouchard B, Beguin PC, Dolinsky VW, Foisy S, Villeneuve LR, Labarthe F, Dyck JR, Allen BG, Charron G, Des Rosiers C. Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart. J Mol Cell Cardiol 51: 99-108, 2011.
30. Lauzier B, Vaillant F, Gelinas R, Bouchard B, Brownsey R, Thorin E, Tardif JC, Des Rosiers C. Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts. Am J Physiol Heart Circ Physiol 300: H845-H852, 2011.
31. Lopaschuk GD, Ussher JR, Folmes CD, Jaswal JS, Stanley WC. Myocardial fatty acid metabolism in health and disease. Physiol Rev 90: 207-258, 2010.
32. Mekada K, Abe K, Murakami A, Nakamura S, Nakata H, Moriwaki K, Obata Y, Yoshiki A. Genetic differences among C57BL/6 substrains. Exp Anim 58: 141-149, 2009.
33. Neubauer S, Krahe T, Schindler R, Horn M, Hillenbrand H, Entzeroth C, Mader H, Kromer EP, Riegger GA, Lackner K,. 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease Altered cardiac high-energy phosphate metabolism in heart failure. Circulation 86: 1810-1818, 1992.
34. Shah AP, Siedlecka U, Gandhi A, Navaratnarajah M, Al-Saud SA, Yacoub MH, Terracciano CM. Genetic background affects function and intracellular calcium regulation of mouse hearts. Cardiovasc Res 87: 683-693, 2010.
35. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129, 2005.
36. Stull LB, Hiranandani N, Kelley MA, Leppo MK, Marban E, Janssen PM. Murine strain differences in contractile function are temperature-and frequency-dependent. Pflugers Arch 452: 140-145, 2006.
37. Turer AT, Malloy CR, Newgard CB, Podgoreanu MV. Energetics and metabolism in the failing heart: important but poorly understood. Curr Opin Clin Nutr Metab Care 13: 458-465, 2010.
38. Tuunanen H, Knuuti J. Metabolic remodelling in human heart failure. Cardiovasc Res 90: 251-257, 2011.
39. Veniant MM, Withycombe S, Young SG. Lipoprotein size and atherosclerosis susceptibility in Apoe-/-and Ldlr-/-mice. Arterioscler Thromb Vasc Biol 21: 1567-1570, 2001.
40. Ventura-Clapier R, Garnier A, Veksler V, Joubert F. Bioenergetics of the failing heart. Biochim Biophys Acta 1813: 1360-1372, 2011.
41. Vincent G, Bouchard B, Khairallah M, Des Rosiers C. Differential modulation of citrate synthesis and release by fatty acids in perfused working rat hearts. Am J Physiol Heart Circ Physiol 286: H257-H266, 2004.
42. 2+ handling gene expression. Front Physiol 4: 11, 2013.
43. Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 296: H1907-H1913, 2009.
44. Zahabi A, Picard S, Fortin N, Reudelhuber TL, Deschepper CF. Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts. J Biol Chem 278: 47694-47699, 2003.
45. 2+ release in cat ventricular myocytes. J Physiol 577: 281-293, 2006.
46. Zurita E, Chagoyen M, Cantero M, Alonso R, Gonzalez-Neira A, Lopez-Jimenez A, Lopez-Moreno JA, Landel CP, Benitez J, Pazos F, Montoliu L. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res 20: 481-489, 2010.