Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 440-446

  Yamaguchi, Hideaki ^a   Kamiie, Katsuyoshi ^b   Kidachi, Yumi ^b   Noshita, Toshiro ^c   Umetsu, Hironori ^d   Fuke, Yoko ^e   Ryoyama, Kazuo ^b  

^a MEIJO UNIVERSITY   (Japan)

^b AOMORI UNIVERSITY   (Japan)

^c PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^d GIFU SHOTOKU GAKUEN UNIVERSITY   (Japan)

^e TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

6 (Methylsulfinyl)hexyl isothiocyanate; Glutathione; Nitric oxide

Indexed keywords

6 (METHYLSULFINYL)HEXYL ISOTHIOCYANIC ACID DERIVATIVE; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELLULAR DISTRIBUTION; DRUG POTENCY; ENZYME REPRESSION; IC 50; IN VITRO STUDY; NONHUMAN; TUMOR CELL;

(±)-N-[(E)-4-ETHYL-2-[(Z)-HYDROXYIMINO]-5-NITRO-3-HEXENE-1-YL]-3-PYRIDINE CARBOXAMIDE; 6-(METHYLSULFINYL)HEXYL ISOTHIOCYANATE; 6MITC; ABC; ATP-BINDING CASSETTE; GLUTATHIONE; GSH; HALF-MAXIMAL INHIBITORY CONCENTRATION; IC(50); IFN-Γ; INDUCIBLE NO SYNTHASE; INOS; INTERFERON REGULATORY FACTOR-1; INTERFERON-GAMMA; IRF-1; ISOTHIOCYANATE; ITC; K(OBS); LBS; LIGAND-BINDING SITE; LIPOPOLYSACCHARIDE; LOGARITHM OF PARTITION COEFFICIENT BETWEEN 1-OCTANOL AND AQUEOUS PHASES; LOGP; LPS; MDR; MULTIDRUG RESISTANCE; NF-ΚB; NITRIC OXIDE; NO; NOR4; NUCLEAR FACTOR-ΚB; P-GLYCOPROTEIN; P-GP; POLAR SURFACE AREA; PSA; PSEUDO-FIRST ORDER REACTION RATE CONSTANT; S-NITROSO-N-ACETYL-DL-PENICILLAMINE; SNAP;

HUMANS; ISOTHIOCYANATES; MACROPHAGES; NITRIC OXIDE;

EID: 84891496633     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.008     Document Type: Article

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