Lentivirus-mediated CD/TK fusion gene transfection neural stem cell therapy for C6 glioblastoma

Tumor Biology

Volumn 34, Issue 6, 2013, Pages 3731-3741

  Niu, Jian ^a   Xing, Chunyang ^a   Yan, Chao ^a   Liu, Hao ^a   Cui, Yuqiong ^a   Peng, Haisheng ^a   Chen, Yingli ^a   Li, Dianjun ^a   Jiang, Chuanlu ^a   Li, Nannan ^a   Yang, Haicheng ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

C6 glioblastoma; CD TK fusion gene; Lentivirus; Neural stem cell

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; GUANOSINE DERIVATIVE; LENTIVIRUS VECTOR; PROPYLGUANOSINE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER PROGNOSIS; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; FUSION GENE; GENE THERAPY; GENETIC TRANSFECTION; GLIOBLASTOMA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIMODALITY CANCER THERAPY; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; STABLE TRANSFECTION; SURVIVAL TIME; TUMOR MODEL; TUMOR VOLUME;

EID: 84891494165     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0957-y     Document Type: Article

References (29)

1. Michotte A, Neyns B, Chaskis C, Sadones J, In 't Veld P. Neuropathological and molecular aspects of low-grade and high-grade gliomas. Acta Neurol Belg. 2004;104(4):148-53.
2. Zhao D, Najbauer J, Garcia E, et al. Neural stem cell tropism to glioma: critical role of tumor hypoxia. Mol Cancer Res MCR. 2008;6(12):1819-29.
3. Chang DY, Yoo SW, Hong Y, Kim S, Kim SJ, Yoon SH, Cho KG, Paek SH, Lee YD, Kim SS, Suh-Kim H. The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase. Int J Cancer. 2010;127:1975-83.
4. Chang JW, Lee H, Kim E, Lee Y, Chung SS, Kim JH. Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma. Neurosurgery. 2000;47(4):931-8. discussion 938-939.
5. Jia W, Mei L, Wang Y, Liu L, Che G. Double suicide genes selectively kill human umbilical vein endothelial cells. Virol J. 2011;8(1):74.
6. Kim SK, Kim SU, Park IH, et al. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin Cancer Res. 2006;12(18):5550-6.
7. Khan Z, Knecht W, Willer M, et al. Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy. Neuro Oncol. 2010;12(6):549-58.
8. Li S, Gao Y, Pu K, Ma L, Song X, Liu Y. All-trans retinoic acid enhances bystander effect of suicide-gene therapy against medulloblastomas. Neurosci Lett. 2011;503(2):115-9.
9. Zhang JX, Kang CS, Shi L, Zhao P, Liu N, You YP. Use of thymidine kinase gene-modified endothelial progenitor cells as a vector targeting angiogenesis in glioma gene therapy. Oncology. 2010;78(2):94-102.
10. Huang Q, Pu P, Xia Z, You Y. Exogenous wt-p53 enhances the antitumor effect of HSV-TK/GCV on C6 glioma cells. J Neurooncol. 2007;82(3):239-48.
11. Ito S, Natsume A, Shimato S, et al. Human neural stem cells transduced with IFN-beta and cytosine deaminase genes intensify bystander effect in experimental glioma. Cancer Gene Ther. 2010;17(5):299-306.
12. Lee DH, Ahn Y, Kim SU, et al. Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells. Clin Cancer Res. 2009;15(15):4925-34.
13. Shimato S, Natsume A, Takeuchi H, et al. Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma. Gene Ther. 2007;14(15):1132-42.
14. Luo XR, Li JS, Niu Y, Miao L. Targeted killing effects of double CD and TK suicide genes controlled by survivin promoter on gastric cancer cell. Mol Biol Rep. 2011;38(2):1201-7.
15. Lee SJ, Kim Y, Jo MY, et al. Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response. Oncol Rep. 2011;25(1):63-8.
16. Imitola J, Raddassi K, Park KI, et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A. 2004;101(52):18117-22.
17. Kendall SE, Najbauer J, Johnston HF, et al. Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling. Stem Cells. 2008;26(6):1575-86.
18. Schmidt NO, Przylecki W, Yang W, et al. Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor. Neoplasia. 2005;7(6):623-9.
19. Guan S, Zhang XL, Ge D, Liu TQ, Ma XH, Cui ZF. Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells. Eur J Pharmacol. 2011;670(2-3):471-8.
20. Erlandsson A, Enarsson M, Forsberg-Nilsson K. Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor. J Neurosci. 2001;21(10):3483-91.
21. You Y, Geng X, Zhao P, et al. Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts. Cell Mol Life Sci. 2007;64(5):621-31.
22. Zhang Y, Wang CW, Wang ZG, et al. Construction of double suicide genes system controlled by MDR1 promoter with targeted expression in drug-resistant glioma cells. J Neurooncol. 2008;86(1):3-11.
23. Ma J, Li M, Mei L, et al. Double suicide genes driven by kinase domain insert containing receptor promoter selectively kill human lung cancer cells. Genet Vaccines and Therapy. 2011;9:6.
24. Wu DH, Liu L, Chen LH. Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells. World J Gastroenterol. 2005;11(20):3051-5.
25. Aboody KS, Brown A, Rainov NG, et al. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A. 2000;97(23):12846-51.
26. Kim SK, Cargioli TG, Machluf M, et al. PEX-producing human neural stem cells inhibit tumor growth in a mouse glioma model. Clin Cancer Res. 2005;11(16):5965-70.
27. Sun L, Lee J, Fine HA. Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. J Clin Invest. 2004;113(9):1364-74.
28. Ehtesham M, Yuan X, Kabos P, et al. Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4. Neoplasia. 2004;6(3):287-93.
29. Goldman S. Stem and progenitor cell-based therapy of the human central nervous system. Nat Biotechnol. 2005;23(7):862-71.