Overexpression of CPE-ΔN predicts poor prognosis in colorectal cancer patients

Tumor Biology

Volumn 34, Issue 6, 2013, Pages 3691-3699

  Zhou, Kun ^a,b   Liang, Hongyan ^a,c   Liu, Yang ^a   Yang, Chun ^a   Liu, Peijia ^a   Jiang, Xiaofeng ^a,c  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Daqing Oilfield General Hospital Group   (China)

^c Heilongjiang Province Key Laboratory of Molecular Imaging   (China)

Author keywords

Carboxypeptidase E; Colorectal cancer; Metastasis; Prognosis; Recurrence

Indexed keywords

CARBOXYPEPTIDASE H; RNA 18S; TUMOR MARKER;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS FREE SURVIVAL; MIDDLE AGED; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECURRENCE FREE SURVIVAL; SEX DIFFERENCE; SURVIVAL RATE; SURVIVAL TIME; TUMOR CLASSIFICATION; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR VOLUME; VERY ELDERLY; WESTERN BLOTTING;

EID: 84891488052     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0952-3     Document Type: Article

References (22)

1. Fricker LD, Snyder SH. Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules. Proc Natl Acad Sci USA. 1982;79:3886-90.
2. Chen H, Jawahar S, Qian Y, et al. Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Hum Mutat. 2001;18(2):120-31.
3. Fricker LD, Carboxypeptidase E. Annu Rev Physiol. 1988;50:309-21.
4. Fricker LD. Activation and membrane binding of Carboxypeptidase E[J]. J Cell Biochem. 1988;38(4):279-89.
5. Fricker LD, Snyder SH. Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase. J Biol Chem. 1983;258:10950-5.
6. Hook VY, Loh YP. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Proc Natl Acad Sci USA. 1984;81(9):2776-80.
7. Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, et al. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell. 1997;88:73-83.
8. Dhanvantari S, Shen FS, Adams T, Snell CR, Zhang C, Mackin RB, et al. Disruption of a receptor-mediated mechanism for intracellular sorting of proinsulin in familial hyperproinsulinemia. Mol Endocrinol. 2003;17:1856-67.
9. Song L, Fricker LD. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary. J Biol Chem. 1995;270(42):25007-13.
10. Ge X, Yamamoto S, Tsutsumi S, Midorikawa Y, Ihara S, Wang SM. Aburatani H Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics. 2005;86:127-41.
11. Murthy SR, Pacak K, Loh YP. Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers. Cell Mol Neurobiol. 2010;30(8):1377-81.
12. Lee TK, Murthy SR, Cawley NX, et al. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest. 2011;121(3):880-92.
13. Cawley NX, Wetsel WC, Murthy SR, Park JJ, Pacak K, Loh YP. New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev. 2012;33:216-53.
14. Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R. Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. Oncogene. 2012; Jul 23. doi: 10.1038/onc.2012.308.
15. -â̂†â̂†CT method. Methods. 2001;25(4):402-8.
16. He P et al. Identification of carboxypeptidase E and gammaglutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol. 2004;35(10):1196-209.
17. Guest PC, Ravazzola M, Davidson HW, Orci L, Hutton JC. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology. 1991;129(2):734-40.
18. Du J, Keegan BP, North WG. Key peptide processing enzymes are expressed by breast cancer cells. Cancer Lett. 2001;165:211-8.
19. Rozengurt E. Neuropeptides as growth factors for normal and cancerous cells. Trends Endocrinol Metab. 2002;13(3):128-34.
20. Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, et al. Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci USA. 2008;105:8452-7.
21. Krajnik M, Schafer M, Sobanski P, et al. Enkephalin, its precursor, processing enzymes, and receptor as part of a local opioid network throughout the respiratory system of lung cancer patients. Hum Pathol. 2010;41:632-42.
22. Horing E, Harter PN, Seznec J, Schittenhelm J, Buhring HJ, Bhattacharyya S, et al. The 'go or grow' potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress. Acta Neuropathol. 2012;124:83-97.