Key peptide processing enzymes are expressed by breast cancer cells

Cancer Letters

Volumn 165, Issue 2, 2001, Pages 211-218

  Du, Jinlin ^a   Keegan, Brendan P ^a   North, William G ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Breast cancer; Carboxypeptidase E; Neuropeptide; Peptidylglycine amidating monooxygenase; Processing; Prohormone convertase; Vasopressin

Indexed keywords

ALPHA AMIDATING ENZYME; CARBOXYPEPTIDASE H; FURIN; VASOPRESSIN;

ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL STRAIN; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; SEQUENCE HOMOLOGY; VASOPRESSIN RELEASE; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CARBOXYPEPTIDASE H; CARBOXYPEPTIDASES; CLONING, MOLECULAR; FURIN; HUMANS; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; RECEPTORS, VASOPRESSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SUBTILISINS; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035953854     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00409-8     Document Type: Article

References (30)

1. Autocrine growth factors and cancer
2. Effect of oxytocin on breast carcinoma cell growth
3. Vasopressin gene related products are markers of human breast cancer
4. MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R
5. Interaction of vasopressin and oxytocin with human breast carcinoma cells
6. Biochemical characterization of peptide alpha-amidation enzyme activities of human neuroendocrine lung cancer cell lines
7. The membrane-bound bifunctional peptidylglycine α-amidating monooxygenase protein: Exploration of its domain structure through limited proteolysis
8. Human carboxypeptidase E: Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro
9. Prohormone and proneuropeptide processing: Recent progress and future challenges
10. The proprotein convertases
11. Structure and function of eukaryotic proprotein processing enzymes
12. Pro-protein convertase gene expression in human breast cancer
13. Proprotein convertases (PC1/PC3 and PC2) in normal and neuroplastic human tissues: Their use as markers of neuroendocrine differentiation
14. Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lung
15. Processing of precarboxypeptidase E into carboxypeptidase E occurs in secretory granules
16. Endoproteolytic processing of proopiomelanocortin and prohormone convertase 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 and 2
17. Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells
18. Expression patterns of messenger ribonucleic acids encoding prohormone convertases (PC2 and PC3) in human pituitary adenomas
19. The cDNA sequence of the human pro-hormone and pro-protein convertase PC1
20. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
21. Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours
22. Carboxypeptidase H a regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells
23. The syndrome of inappropriate secretion of antidiuretic hormone in a case of carcinoma of the breast
24. Breast carcinoma presenting with inappropriate ADH secretion
25. Mammalian neural and endocrine pro-protein and pro-hormone
26. Distribution of peptidylglycine alpha-amidating mono-oxygenase (PAM) enzymes in normal human lung and in lung epithelial tumors
27. Peptidylglycine alpha-amidating mono-oxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours
28. Expression in human lung cancer cell lines of genes of prohormone processing and the neuroendocrine phenotype
29. Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary
30. Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor growth inhibitors