Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6827-6830

  Wood, Michael R ^a,b   Schirripa, Kathy M ^a   Kim, June J ^a   Bednar, Rodney A ^a   Fay, John F ^a   Bruno, Joseph G ^a   Moore, Eric L ^a   Mosser, Scott D ^a   Roller, Shane ^a   Salvatore, Christopher A ^a   Vacca, Joseph P ^a   Selnick, Harold G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antagonist; Calcitonin gene related peptide; CGRP

Indexed keywords

AMIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; LACTAM DERIVATIVE; NAPHTHYRIDINE DERIVATIVE; QUINOLINE;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR BINDING; SCANNING ELECTRON MICROSCOPY; STRUCTURE ACTIVITY RELATION;

AMIDES; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; STEREOISOMERISM;

EID: 77958068048     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.105     Document Type: Article

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15. Ketones 23 and 27 will be the subject of future communications.