The discovery of highly potent CGRP receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 214-217

  Stump, Craig A ^a   Bell, Ian M ^a   Bednar, Rodney A ^a   Bruno, Joseph G ^a   Fay, John F ^a   Gallicchio, Steven N ^a   Johnston, Victor K ^a   Moore, Eric L ^a   Mosser, Scott D ^a   Quigley, Amy G ^a   Salvatore, Christopher A ^a   Theberge, Cory R ^a   Blair Zartman, C ^a   Zhang, Xu Fang ^a   Kane, Stefanie A ^a   Graham, Samuel L ^a   Vacca, Joseph P ^a   Williams, Theresa M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CGRP; Headache; Migraine

Indexed keywords

BENZIMIDAZOLINONE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; HYDANTOIN; IMIDAZOLE DERIVATIVE; INDANYLSPIROAZAOXINDOLE DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MIGRAINE; NONHUMAN; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; DRUG DISCOVERY; HUMANS; INDOLES; MACACA MULATTA; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS;

EID: 57849129258     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.106     Document Type: Article

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