메뉴 건너뛰기
Bioorganic and Medicinal Chemistry Letters
Volumn 24, Issue 1, 2014, Pages 367-370
Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
Author keywords

Antibacterial agents; Antibiotics; Quinolines; Staphylococcus aureus
Indexed keywords

2 FORMYL 8 HYDROXYQUINOLINIUM CHLORIDE; 4 QUINOLINOL; 5,7 DIBROMO 2 METHYLQUINOLIN 8 OL; 6 HYDROXYQUINOLINE; 7 HYDROXYQUINOLINE; 8 (BENZYLOXY) 2 METHYLQUINOLINE; 8 [2 (PIPERIDIN 1 YL)ETHOXY] 2 METHYLQUINOLINE; 8 BUTOXY 2 METHYLQUINOLINE; 8 ETHOXY 2 METHYLQUINOLINE; 8 HYDROXY 2 QUINOLINECARBALDEHYDE; 8 HYDROXYQUINALDINE; 8 METHOXY 2 METHYLQUINOLINE; 8 QUINOLINOL; 8 QUINOLINOL DERIVATIVE; ANTIBIOTIC AGENT; DOXORUBICIN; METICILLIN; UNCLASSIFIED DRUG;
EID: 84891419911     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.072     Document Type: Article
Times cited : (45)
References (34)
  • 1
    • 9644295892 scopus 로고    scopus 로고
    • National Nosocomial Infections Surveillance (NNIS) System
    • National Nosocomial Infections Surveillance (NNIS) System. Am. J. Infect. Control 2004, 32, 470.
    • (2004) Am. J. Infect. Control , vol.32 , pp. 470
  • 32
    • 84891413726 scopus 로고    scopus 로고
    • +, 315.8973; found 315.8981; Melting Point = 126.9-128.5 C; Yield = 64%.
    • +, 315.8973; found 315.8981; Melting Point = 126.9-128.5 C; Yield = 64%.
  • 33
    • 84891442685 scopus 로고    scopus 로고
    • 6 cell/mL. The MIC values of synthesized compounds were determined by the LB broth dilution method. Various concentrations of compounds were added from a starting concentration of 50 μg/mL (stocks were prepared as 50 mg/mL in dimethylsulfoxide, DMSO) and they were diluted serially in the 96 wells microtitre plate. Methicillin was used as a positive control for S. aureus (started at 50 μg/mL) and ampicillin was used as positive control for E. coli (started at 30 μg/mL) while 0.1% DMSO was used as a vehicle control. They were then incubated at 37 C for 24 h. The minimum concentrations of compounds that induced a complete growth inhibition will be recorded as MIC values.
    • 6 cell/mL. The MIC values of synthesized compounds were determined by the LB broth dilution method. Various concentrations of compounds were added from a starting concentration of 50 μg/mL (stocks were prepared as 50 mg/mL in dimethylsulfoxide, DMSO) and they were diluted serially in the 96 wells microtitre plate. Methicillin was used as a positive control for S. aureus (started at 50 μg/mL) and ampicillin was used as positive control for E. coli (started at 30 μg/mL) while 0.1% DMSO was used as a vehicle control. They were then incubated at 37 C for 24 h. The minimum concentrations of compounds that induced a complete growth inhibition will be recorded as MIC values.
  • 34
    • 84891445125 scopus 로고    scopus 로고
    • Zone of inhibition study. S. aureus was used to study the anti-bacterial activity of compounds 2a, 2b and 4 against its grown in culture. S. aureus was diluted with broth medium and plated on the nutrient agar plate and the holes were created on the agar using a sterile transfer pipette. The tested compounds and methicillin (as positive control) were placed in the holes of agar. The plates were then incubated at 37 C for 24 h and the inhibition zones (mm, in terms of radius) of bacteria on the agar plates were recorded.
    • Zone of inhibition study. S. aureus was used to study the anti-bacterial activity of compounds 2a, 2b and 4 against its grown in culture. S. aureus was diluted with broth medium and plated on the nutrient agar plate and the holes were created on the agar using a sterile transfer pipette. The tested compounds and methicillin (as positive control) were placed in the holes of agar. The plates were then incubated at 37 C for 24 h and the inhibition zones (mm, in terms of radius) of bacteria on the agar plates were recorded.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.