5-Hydroxy-6-quinaldic acid as a novel molecular scaffold for HIV-1 integrase inhibitors

Letters in Drug Design and Discovery

Volumn 3, Issue 3, 2006, Pages 175-178

  Polanski, J ^a   Niedbala, H ^a   Musiol, R ^a   Podeszwa, B ^a   Tabak, D ^a   Palka, A ^a   Mencel, A ^a   Finster, J ^a   Mouscadet, J F ^b   Le Bret, M ^b  

^a UNIVERSITY OF SILESIA   (Poland)

^b Ecole Normale Superieure de Cachan   (France)

Author keywords

HIV integrase inhibitors; Molecular scaffold; Styrylquinolines

Indexed keywords

5 HYDROXY 6 QUINALDIC ACID; 5 HYDROXY 8 NITRO 6 QUINALDIC ACID; ANTIVIRUS AGENT; INTEGRASE; INTEGRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 33645883847     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018006776286934     Document Type: Article

References (19)

1. Fattori, D. D. Drug Discov. Today, 2004, 9, 229.
2. Erlanson, D. A.; McDowell, R. S.; O'Brien, T. J. Med. Chem., 2004, 47, 3463.
3. Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science, 1996, 274, 1531.
4. Hazuda, D. J.; Felock, P.; Witmer, M.; Wolfe, A.; Stillmock, K.; Grobler, J. A.; Espeseth, A.; Gabryelski, L.; Schleif, W.; Blau, C.; Miller, M. D. Science, 2000, 28, 7646.
5. Long, Y. Q.; Jiang, X-H.; Dayam, R.; Sanchez, T.; Shoemaker, R.; Sei, S.; Neamati, N. J. Med. Chem., 2004, 47, 2561.
6. Shaw-Reid, C. A.; Munshi, V.; Graham, P.; Wolfe, A.; Witmer, M.; Danzeisen, R.; Olsen, D. B.; Carroll, S. S.; Embrey, M.; Wai, J. S.; Miller, M. D.; Cole, J. L.; Hazuda, D. J. J. Biol. Chem., 2003, 278, 2777.
7. Hastings, J. C.; Selnick, H.; Wolanski, B.; Tomassini, J. E. Antimicrob. Agents Chemother., 1996, 40, 1304.
8. Johnson, A. A.; Marchand, C.; Pommier, Y. Curr. Topics Med. Chem., 2004, 4, 671.
9. Mekouar, K.; Mouscadet, J. F.; Desmaele, D.; Subra, F.; Leh, H.; Savoure, D.; Auclair, C.; d'Angelo, J. J. Med. Chem., 1998, 41, 2846.
10. Ouali, M.; Laboulais, C.; Leh, H.; Gill, D.; Desmaele, D.; Mekouar, K.; Zouhiri, F.; d'Angelo, J.; Auclair, C.; Mouscadet, J. F.; Le Bret, M. J. Med. Chem., 2000, 43, 1949.
11. Zouhiri, F.; Mouscadet, J. F.; Mekouar, K.; Desmaele, D.; Savoure, D.; Leh, H.; Subra, F.; Le Bret, M.; Auclair, Ch.; d'Angelo, J. J. Med. Chem., 2000, 43, 1533.
12. Polanski, J.; Zouhiri, F.; Jeanson, L.; Desmaële, D.; d'Angelo, J.; Mouscadet, J.-F.; Gieleciak, R.; Gasteiger, J.; Le Bret, M. J. Med. Chem., 2002, 45, 4647.
13. Zouhiri, F.; Desmaele, D.; d'Angelo, J.; Ourevitch, M.; Mouscadet, J.-F.; Leh, H.; Le Bret, M. Tetrahedron Lett., 2001, 42, 8189.
14. Benard, Ch.; Zouhiri, F.; Normand-Bayle, M.; Danet, M.; Desmaele, D.; Leh, H.; Mouscadet, J.-F.; Mbemba, G.; Thomas, C.-M.; Bonnenfant, S.; Le Bret, M.; d'Angelo, J. Bioorg. Med. Chem. Lett., 2004, 14, 2473.
15. Pommier, Y.; Johnson, A. A.; Marchand, C. Nat. Rev. Drug Discov., 2005, 4, 236.
16. Zhuang, L.; Wai, J. S.; Embrey, M. W.; Fisher, T. E.; Egbertson, M. S.; Payne, L. S.; Guare, J. P.; Vacca, J.P.; Hazuda, D. J.; Felock, P. J.; Wolfe, A. L.; Stillmock, K. A.; Witmer, M. V.; Moyer, G.; Schleif, W. A.; Gabryelski, L. J.; Leonard, Y. M.; Lynch, J. J.; Michelson, S. R.; Young, S. D. J. Med. Chem., 2003, 46, 453.
17. (a) Gershon, H.; McNeil, M. W. J. Heterocycl. Chem., 1972, 9, 659;
18. (b) Gershon, H.; McNeil, M. W.; Grefig A. T. J. Org. Chem., 1969, 34, 3268;
19. (c) Behforouz, M.; Haddad, J.; Cai, W.; Arnold, M. B.; Mohammadi, F.; Sousa, A. C.; Horn, M. A. J. Org. Chem., 1996, 61, 6552.