메뉴 건너뛰기




Volumn 4, Issue 1, 2012, Pages 25-39

Hibiscus sabdariffa L., roselle calyx, from ethnobotany to pharmacology

Author keywords

Anthocyanins; Antihypertensive; Apoptosis; Lipid metabolism; Phenolic; Polyphenolic compounds; Safe effective herbal therapeutic product

Indexed keywords

AFLATOXIN; ANTHOCYANIDIN; ANTHOCYANIN; ASCORBIC ACID; BETA CAROTENE; CALCIUM; CITRIC ACID; CYANIDIN 3 GLUCOSIDE; DELPHINIDIN; EUGENOL; HIBISCUS SABDARIFFA EXTRACT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IRON; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; MALIC ACID; MALVIN; OXALIC ACID; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; PROTOCATECHUIC ACID; QUERCETIN; RIBOFLAVIN; RUTOSIDE; SOLVENT; TARTARIC ACID; THIAMINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84891413797     PISSN: None     EISSN: 11791454     Source Type: Journal    
DOI: 10.2147/JEP.S27974     Document Type: Review
Times cited : (45)

References (64)
  • 1
    • 84984477771 scopus 로고
    • Biochemical dynamics and hypocholesterolemic action of Hibiscus sabdariffa (Karkade)
    • El-Saadany SS, Sitohy MZ, Labib SM, El-Massry RA. Biochemical dynamics and hypocholesterolemic action of Hibiscus sabdariffa (Karkade). Nahrung. 1991;35:567-576.
    • (1991) Nahrung , vol.35 , pp. 567-576
    • El-Saadany, S.S.1    Sitohy, M.Z.2    Labib, S.M.3    El-Massry, R.A.4
  • 2
    • 33751155307 scopus 로고    scopus 로고
    • Scripps Research Institute thrives at interface of chemistry and biology
    • Wilson EK. Scripps Research Institute thrives at interface of chemistry and biology. Chem Eng News. 1996;174:39-44.
    • (1996) Chem Eng News , vol.174 , pp. 39-44
    • Wilson, E.K.1
  • 3
    • 0032874690 scopus 로고    scopus 로고
    • Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats
    • Onyenekwe PC, Ajani EO, Ameh DA, et al. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell Biochem Funct. 1999;17:199-206.
    • (1999) Cell Biochem Funct , vol.17 , pp. 199-206
    • Onyenekwe, P.C.1    Ajani, E.O.2    Ameh, D.A.3
  • 4
    • 0032769130 scopus 로고    scopus 로고
    • The effect of sour tea (Hibiscus sabdariffa) on essential hypertension
    • Haji-Faraji MH, Haji-Tarkhani AH. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. J Ethnopharmacol. 1999;65: 231-236.
    • (1999) J Ethnopharmacol , vol.65 , pp. 231-236
    • Haji-Faraji, M.H.1    Haji-Tarkhani, A.H.2
  • 5
    • 0034030162 scopus 로고    scopus 로고
    • Protective effect of Hibiscus anthocyanins against ter-butyl hydroperoxide-induced hepatic toxicity in rats
    • Wang CJ, Wang JM, Lin WL, et al. Protective effect of Hibiscus anthocyanins against ter-butyl hydroperoxide-induced hepatic toxicity in rats. Food Chem Toxicol. 2000;38:411-416.
    • (2000) Food Chem Toxicol , vol.38 , pp. 411-416
    • Wang, C.J.1    Wang, J.M.2    Lin, W.L.3
  • 8
    • 0042513717 scopus 로고    scopus 로고
    • Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits
    • Chen CC, Hsu JD, Wang SF, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem. 2003;51:5472-5477.
    • (2003) J Agric Food Chem , vol.51 , pp. 5472-5477
    • Chen, C.C.1    Hsu, J.D.2    Wang, S.F.3
  • 9
    • 8744317028 scopus 로고    scopus 로고
    • Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and antihyperlipidemia in fructose-fed and cholesterol-fed rats
    • Chen CC, Chou FP, Ho YC, et al. Inhibitory effects of Hibiscus sabdariffa L extract on low-density lipoprotein oxidation and antihyperlipidemia in fructose-fed and cholesterol-fed rats. J Sci Food Agric. 2004;84:1989-1996.
    • (2004) J Sci Food Agric , vol.84 , pp. 1989-1996
    • Chen, C.C.1    Chou, F.P.2    Ho, Y.C.3
  • 10
    • 0037625622 scopus 로고    scopus 로고
    • Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1 hypertensive rats
    • Odigie IP, Ettarh RR, Adigun SA. Chronic administration of aqueous extract of Hibiscus sabdariffa attenuates hypertension and reverses cardiac hypertrophy in 2K-1 hypertensive rats. J Ethnopharmacol. 2003;86:181-185.
    • (2003) J Ethnopharmacol , vol.86 , pp. 181-185
    • Odigie, I.P.1    Ettarh, R.R.2    Adigun, S.A.3
  • 11
    • 3242762157 scopus 로고    scopus 로고
    • Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild moderate hypertension: A controlled and randomized clinical trial
    • Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, et al. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa in patients with mild moderate hypertension: a controlled and randomized clinical trial. Phytomed. 2004;11:375-382.
    • (2004) Phytomed , vol.11 , pp. 375-382
    • Herrera-Arellano, A.1    Flores-Romero, S.2    Chávez-Soto, M.A.3
  • 12
    • 33847771426 scopus 로고    scopus 로고
    • Clinical effects produced by a standardized herbal medical product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial
    • Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, et al. Clinical effects produced by a standardized herbal medical product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007;73:6-12.
    • (2007) Planta Med , vol.73 , pp. 6-12
    • Herrera-Arellano, A.1    Miranda-Sánchez, J.2    Avila-Castro, P.3
  • 13
    • 30144441517 scopus 로고    scopus 로고
    • The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats
    • Carvajal-Zarrabal O, Waliszewski SM, Barradas-Dermitz DM, et al. The consumption of Hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plant Foods Hum Nutr. 2005;60:153-159.
    • (2005) Plant Foods Hum Nutr , vol.60 , pp. 153-159
    • Carvajal-Zarrabal, O.1    Waliszewski, S.M.2    Barradas-Dermitz, D.M.3
  • 14
    • 70349237035 scopus 로고    scopus 로고
    • Effect of Hibiscus sabdariffa dried calyx ethanolic extract on fat absorptionexcretion and body weight implication in rats
    • Carvajal-Zarrabal O, Hayward-Jones PM, Orta-Flores Z, et al. Effect of Hibiscus sabdariffa dried calyx ethanolic extract on fat absorptionexcretion and body weight implication in rats. J Biomed Biotechnol. 2009;2009:394592.
    • (2009) J Biomed Biotechnol , vol.2009 , pp. 394592
    • Carvajal-Zarrabal, O.1    Hayward-Jones, P.M.2    Orta-Flores, Z.3
  • 15
    • 29144478796 scopus 로고    scopus 로고
    • Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats
    • Hirunpanich V, Utaipat A, Morales NP, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol. 2006;103:252-260.
    • (2006) J Ethnopharmacol , vol.103 , pp. 252-260
    • Hirunpanich, V.1    Utaipat, A.2    Morales, N.P.3
  • 16
    • 33744941818 scopus 로고    scopus 로고
    • Hibiscus anthocyanin-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis
    • Chang YC, Huang KX, Huang AC, et al. Hibiscus anthocyanin-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem Toxicol. 2006;44:1015-1023.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1015-1023
    • Chang, Y.C.1    Huang, K.X.2    Huang, A.C.3
  • 17
    • 20344400374 scopus 로고    scopus 로고
    • Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
    • Lin HH, Huang HP, Huang CC, et al. Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway. Mol Carcin. 2005;43:86-99.
    • (2005) Mol Carcin , vol.43 , pp. 86-99
    • Lin, H.H.1    Huang, H.P.2    Huang, C.C.3
  • 18
    • 34247381960 scopus 로고    scopus 로고
    • Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation
    • Lin HH, Chen JH, Huang CC, et al. Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. Int. J Cancer. 2007;120: 2306-2316.
    • (2007) Int. J Cancer , vol.120 , pp. 2306-2316
    • Lin, H.H.1    Chen, J.H.2    Huang, C.C.3
  • 19
    • 33845664536 scopus 로고    scopus 로고
    • Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
    • Lin HH, Chen JH, Kuo WH, et al. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact. 2007;165:59-75.
    • (2007) Chem Biol Interact , vol.165 , pp. 59-75
    • Lin, H.H.1    Chen, J.H.2    Kuo, W.H.3
  • 20
    • 33947097011 scopus 로고    scopus 로고
    • Hibiscus sabdariffa extract reduces serum cholesterol in men and women
    • Lin TL, Lin HH, Chen CC, et al. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nut Res. 2007;2:140-145.
    • (2007) Nut Res , vol.2 , pp. 140-145
    • Lin, T.L.1    Lin, H.H.2    Chen, C.C.3
  • 21
    • 33845970583 scopus 로고    scopus 로고
    • Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces
    • Ajay M, Chai HJ, Mustafa AM, et al. Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. J Ethnopharmacol. 2007;109:338-393.
    • (2007) J Ethnopharmacol , vol.109 , pp. 338-393
    • Ajay, M.1    Chai, H.J.2    Mustafa, A.M.3
  • 22
    • 0025655003 scopus 로고    scopus 로고
    • The role of ethnopharmacology in drug development
    • Chadwick DJ, Marsh J, editors, Novartis Foundation Symposia; 1990. September 28
    • Farnsworth NR. The role of ethnopharmacology in drug development. In: Chadwick DJ, Marsh J, editors. Ciba Foundation 154-Bioactive Compounds from Plants. Novartis Foundation Symposia; 1990. September 28, 2007.
    • (2007) Ciba Foundation 154-Bioactive Compounds from Plants
    • Farnsworth, N.R.1
  • 23
    • 24644492365 scopus 로고    scopus 로고
    • Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: A Review
    • Ali BH, Naser AWN, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: A Review. Phytother Res. 2005;19:369-375.
    • (2005) Phytother Res , vol.19 , pp. 369-375
    • Ali, B.H.1    Awn, N.2    Blunden, G.3
  • 24
    • 68349113775 scopus 로고    scopus 로고
    • Pharmacological evidences of the extracts and secondary metabolites from plants of the genus Hibiscus
    • Gomes ME, da Costa HR, Moreira RR, et al. Pharmacological evidences of the extracts and secondary metabolites from plants of the genus Hibiscus. Food Chem. 2010;118:1-10.
    • (2010) Food Chem , vol.118 , pp. 1-10
    • Gomes, M.E.1    Da Costa, H.R.2    Moreira, R.R.3
  • 25
    • 18644386388 scopus 로고    scopus 로고
    • Chemical compositions of two varieties of sorrel (Hibiscus sabdariffa L.), calyces and the drinks made from them
    • Nnam NM, y Onyeke NG. Chemical compositions of two varieties of sorrel (Hibiscus sabdariffa L.), calyces and the drinks made from them. Plant Foods Hum Nutr. 2003;58:1-7.
    • (2003) Plant Foods Hum Nutr , vol.58 , pp. 1-7
    • Nnam, N.M.1    Onyeke, N.G.2
  • 26
    • 33746136060 scopus 로고    scopus 로고
    • Roselle (Hibiscus sabdariffa) calyx diet and histopathological changes in liver of albino rats
    • Ojokoh AO. Roselle (Hibiscus sabdariffa) calyx diet and histopathological changes in liver of albino rats. Pak J Nutr. 2006;5:110-113.
    • (2006) Pak J Nutr , vol.5 , pp. 110-113
    • Ojokoh, A.O.1
  • 27
    • 33845754428 scopus 로고    scopus 로고
    • Nutritive value of the two varieties of roselle (Hibiscus sabdariffa) calyces soaked with wood ash
    • Adanlawo IG, Ajibade VA. Nutritive value of the two varieties of roselle (Hibiscus sabdariffa) calyces soaked with wood ash. Pak J Nutr. 2006;5:555-557.
    • (2006) Pak J Nutr , vol.5 , pp. 555-557
    • Adanlawo, I.G.1    Ajibade, V.A.2
  • 28
    • 25444488289 scopus 로고    scopus 로고
    • The chemical composition and membrane stability activity of some herbs used in local therapy for anemia
    • Falade OS, Otemuyiwa IO, Oladipo A, et al. The chemical composition and membrane stability activity of some herbs used in local therapy for anemia. J Ethnopharmacol. 2005;102:15-22.
    • (2005) J Ethnopharmacol , vol.102 , pp. 15-22
    • Falade, O.S.1    Otemuyiwa, I.O.2    Oladipo, A.3
  • 29
    • 0001551060 scopus 로고    scopus 로고
    • Variation in mineral composition of vegetables
    • Bear FE, Toth SJ, Prince AL. Variation in mineral composition of vegetables. Soil Sc Soc Am Proc. 1948;13:380-384.
    • Soil Sc Soc Am Proc. , vol.1948 , Issue.13 , pp. 380-384
    • Bear, F.E.1    Toth, S.J.2    Prince, A.L.3
  • 31
    • 0036864425 scopus 로고    scopus 로고
    • Characteristics of mixed hyperlipidemia cases in a population-based study: Results from the Mexican National Survey of Chronic Diseases
    • Aguilar-Salinas CA, Rojas R, Gómez-Pérez FJ, et al. Characteristics of mixed hyperlipidemia cases in a population-based study: Results from the Mexican National Survey of Chronic Diseases. Salud Pública de México. 2002;44:546-553.
    • (2002) Salud Pública de México , vol.44 , pp. 546-553
    • Aguilar-Salinas, C.A.1    Rojas, R.2    Gómez-Pérez, F.J.3
  • 32
    • 0030611999 scopus 로고    scopus 로고
    • The münster heart study (PROCAM)
    • Cullen P, Schulte H, Assmann G. The Münster Heart Study (PROCAM). Circulation. 1997;96:2128-2136.
    • (1997) Circulation , vol.96 , pp. 2128-2136
    • Cullen, P.1    Schulte, H.2    Assmann, G.3
  • 33
    • 0028181736 scopus 로고
    • Systematic underestimation of association between serum cholesterol concentration and ischemic heart disease in observational studies: Data from the BUPA Study
    • Law MR, Wald NJ, Wu T, et al. Systematic underestimation of association between serum cholesterol concentration and ischemic heart disease in observational studies: data from the BUPA Study. BMJ. 1994;308:363-366.
    • (1994) BMJ , vol.308 , pp. 363-366
    • Law, M.R.1    Wald, N.J.2    Wu, T.3
  • 34
    • 0026681128 scopus 로고
    • For the multiple risk factor Intervention trial research group. Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial
    • Neaton JD, Blackburn H, Jacobs D, et al. For the multiple risk factor Intervention trial research group. Serum cholesterol level and mortality findings for men screened in the multiple risk factor intervention trial. Arch Intern Med. 1992;152:1490-1500.
    • (1992) Arch Intern Med , vol.152 , pp. 1490-1500
    • Neaton, J.D.1    Blackburn, H.2    Jacobs, D.3
  • 35
    • 0026647739 scopus 로고
    • Short-and long-term association of serum cholesterol with mortality: The 25-year follow-up of the Finnish cohorts of the seven countries study
    • Pekkanen J, Nissinen A, Punsar S, et al. Short- and long-term association of serum cholesterol with mortality: the 25-year follow-up of the Finnish cohorts of the seven countries study. Am J Epidemiol. 1992;135:1251-1258.
    • (1992) Am J Epidemiol , vol.135 , pp. 1251-1258
    • Pekkanen, J.1    Nissinen, A.2    Punsar, S.3
  • 36
    • 0027092441 scopus 로고
    • Role of triacylglycerides in coronary artery disease: Lessons from the prospective cardiovascular Munster study
    • Assmann G, Schulte H. Role of triacylglycerides in coronary artery disease: lessons from the prospective cardiovascular Munster study. Am J Cardiol. 1992;70:10H-13H.
    • (1992) Am J Cardiol , vol.70
    • Assmann, G.1    Schulte, H.2
  • 37
    • 0024230807 scopus 로고
    • High-density lipoprotein cholesterol and mortality: The Framingham Study
    • Wilson PFW, Abbott RD, Castelli WP. High-density lipoprotein cholesterol and mortality: the Framingham Study. Arteriosclerosis. 1988;8:737-741.
    • (1988) Arteriosclerosis , vol.8 , pp. 737-741
    • Pfw, W.1    Abbott, R.D.2    Castelli, W.P.3
  • 38
    • 0023121401 scopus 로고
    • Cholesterol and mortality: 30 years of follow-up from the Framingham Study
    • Anderson KM, Castelli WP, Levy D. Cholesterol and mortality: 30 years of follow-up from the Framingham Study. JAMA. 1987;257: 2176-2180.
    • (1987) JAMA , vol.257 , pp. 2176-2180
    • Anderson, K.M.1    Castelli, W.P.2    Levy, D.3
  • 39
    • 0037126729 scopus 로고    scopus 로고
    • Third report of NCEP expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Final Report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and treatment of high blood cholesterol in adults
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and treatment of high blood cholesterol in adults. Third report of NCEP expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) Final Report. Circulation. 2002;106:3143-3421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 40
    • 0037181323 scopus 로고    scopus 로고
    • Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by copper ion or nitric oxide donor
    • Lee MJ, Cho FP, Tseng TH, et al. Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by copper ion or nitric oxide donor. J Agric Food Chem. 2002;50:2130-2136.
    • (2002) J Agric Food Chem , vol.50 , pp. 2130-2136
    • Lee, M.J.1    Cho, F.P.2    Tseng, T.H.3
  • 41
    • 33748748735 scopus 로고    scopus 로고
    • Protective influence of Hibiscus sabdariffa, an edible medicinal plant, on tissue lipid peroxidation and antioxidant status in hyperammonemic rats
    • Mohamed Essa M, Subramanian P, Manivasagam T, et al. Protective influence of Hibiscus sabdariffa, an edible medicinal plant, on tissue lipid peroxidation and antioxidant status in hyperammonemic rats. African Journal of Traditional, Complementary and Alternative Medicine. 2006;3:10-21.
    • (2006) African Journal of Traditional, Complementary and Alternative Medicine , vol.3 , pp. 10-21
    • Mohamed Essa, M.1    Subramanian, P.2    Manivasagam, T.3
  • 42
    • 74849134733 scopus 로고    scopus 로고
    • The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance
    • Yang MY, Peng CH, Chan KC, et al. The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. J Agr Food Chem. 2010;58:850-859.
    • (2010) J Agr Food Chem , vol.58 , pp. 850-859
    • Yang, M.Y.1    Peng, C.H.2    Chan, K.C.3
  • 43
    • 0036360055 scopus 로고    scopus 로고
    • Arterial hypertension in Mexico: Results of the National Health Survey (ENSA) 2000 [Hipertensión arterial en México: Resultados de la Encuesta Nacional de Salud (ENSA) 2000]
    • [Sanish]
    • Velázquez-Monroy O, Rosas-Peralta M, Lara-Esqueda A, et al. Arterial hypertension in Mexico: Results of the National Health Survey (ENSA) 2000 [Hipertensión arterial en México: Resultados de la Encuesta Nacional de Salud (ENSA) 2000]. Arch Card Méx. 2002;72:71-84. [Spanish.]
    • (2002) Arch Card Méx , vol.72 , pp. 71-84
    • Velázquez-Monroy, O.1    Rosas-Peralta, M.2    Lara-Esqueda, A.3
  • 44
    • 0026071602 scopus 로고
    • Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces
    • Ali MB, Salih WM, Mohamed AH, et al. Investigation of the antispasmodic potential of Hibiscus sabdariffa calyces. J Ethnopharmacol. 1991;31:249-257.
    • (1991) J Ethnopharmacol , vol.31 , pp. 249-257
    • Ali, M.B.1    Salih, W.M.2    Mohamed, A.H.3
  • 46
    • 0038220138 scopus 로고    scopus 로고
    • MSc. Thesis. Chang Mai, Thailand: Department of Pharmacology, Chiang Mai University
    • Tiamjan R. Hypotensive activity of Hibiscus sabdariffa Linn. MSc Thesis. Chang Mai, Thailand: Department of Pharmacology, Chiang Mai University; 1999.
    • (1999) Hypotensive Activity of Hibiscus Sabdariffa Linn
    • Tiamjan, R.1
  • 47
    • 34248661566 scopus 로고    scopus 로고
    • Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa
    • Mojiminiyi FBO, Dikko M, Muhammad BY, et al. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia. 2007;78:292-297.
    • (2007) Fitoterapia , vol.78 , pp. 292-297
    • Fbo, M.1    Dikko, M.2    Muhammad, B.Y.3
  • 48
    • 57749204582 scopus 로고    scopus 로고
    • The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes
    • Mozaffari-Khosravi H, Jalali-Khanabadi B-A, Afkhami-Ardekani M, et al. The effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetes. J Hum Hypertens. 2009;23:48-54.
    • (2009) J Hum Hypertens , vol.23 , pp. 48-54
    • Mozaffari-Khosravi, H.1    Jalali-Khanabadi, B.-A.2    Afkhami-Ardekani, M.3
  • 49
    • 74949122412 scopus 로고    scopus 로고
    • Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults
    • McKay DL, Chen CY, Saltzman E, et al. Hibiscus sabdariffa L. tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr. 2010;140:298-303.
    • (2010) J Nutr , vol.140 , pp. 298-303
    • McKay, D.L.1    Chen, C.Y.2    Saltzman, E.3
  • 50
    • 72449151640 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin- 3-O-sambubiosides from Hibiscus sabdariffa
    • Ojeda D, Jiménez-Ferrer E, Zamilpa A, et al. Inhibition of angiotensin converting enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin- 3-O-sambubiosides from Hibiscus sabdariffa. J Ethnopharmacol. 2010;127:7-10.
    • (2010) J Ethnopharmacol , vol.127 , pp. 7-10
    • Ojeda, D.1    Jiménez-Ferrer, E.2    Zamilpa, A.3
  • 51
    • 0023581693 scopus 로고
    • Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity
    • Kameda K, Takaku T, Okuda H, et al. Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987;50:680-683.
    • (1987) J Nat Prod , vol.50 , pp. 680-683
    • Kameda, K.1    Takaku, T.2    Okuda, H.3
  • 52
    • 33846640446 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Allanthus excelsa (Roxb) (Simaroubaceae)
    • Loizzo MR, Said A, Tundis R, et al. Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated from Allanthus excelsa (Roxb) (Simaroubaceae). Phytother Res. 2007;21:32-36.
    • (2007) Phytother Res , vol.21 , pp. 32-36
    • Loizzo, M.R.1    Said, A.2    Tundis, R.3
  • 53
    • 0026637932 scopus 로고
    • Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterosperum lanceolatum
    • Chen CH, Lin JY, Lin, CN, et al. Inhibition of angiotensin-I-converting enzyme by tetrahydroxyxanthones isolated from Tripterosperum lanceolatum. J Nat Prod. 1992;55:691-695.
    • (1992) J Nat Prod , vol.55 , pp. 691-695
    • Chen, C.H.1    Lin, J.Y.2    Lin, C.N.3
  • 54
    • 76749120557 scopus 로고    scopus 로고
    • Interpretable correlation descriptors for quantitative structure-activity relationships
    • Spowage BM, Bruce CL, Hirst JD. Interpretable correlation descriptors for quantitative structure-activity relationships. J Cheminform. 2009;1:22.
    • (2009) J Cheminform , vol.1 , pp. 22
    • Spowage, B.M.1    Bruce, C.L.2    Hirst, J.D.3
  • 55
    • 73449146247 scopus 로고    scopus 로고
    • The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: A systematic review
    • Wahabi HA, Alansary LA, Al-Sabban AH, et al. The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: A systematic review. Phytomed. 2010;17:83-86.
    • (2010) Phytomed , vol.17 , pp. 83-86
    • Wahabi, H.A.1    Alansary, L.A.2    Al-Sabban, A.H.3
  • 56
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore A, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, A.2    Carroll, D.3
  • 58
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 59
    • 36849079510 scopus 로고    scopus 로고
    • Apoptosis in health and disease and modulation of apoptosis for therapy: An overview
    • Singh N. Apoptosis in health and disease and modulation of apoptosis for therapy: an overview. Indian J Clin Biochem. 2007;22(2):6-16.
    • (2007) Indian J Clin Biochem , vol.22 , Issue.2 , pp. 6-16
    • Singh, N.1
  • 60
    • 0030914282 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
    • Goillot E, Raingeaud J, Ranger A, et al. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A. 1997;94:3302-3307.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3302-3307
    • Goillot, E.1    Raingeaud, J.2    Ranger, A.3
  • 61
    • 0037389558 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress
    • Cowan KJ, Storey KB. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol. 2003;206:1107-1115.
    • (2003) J Exp Biol , vol.206 , pp. 1107-1115
    • Cowan, K.J.1    Storey, K.B.2
  • 62
    • 0034256987 scopus 로고    scopus 로고
    • Induction of apoptosis by Hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression
    • Tseng TH, Kao TW, Chu CY, et al. Induction of apoptosis by Hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol. 2000;60:307-315.
    • (2000) Biochem Pharmacol , vol.60 , pp. 307-315
    • Tseng, T.H.1    Kao, T.W.2    Chu, C.Y.3
  • 63
    • 14044273131 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects of selective phenolic acids on TD47 human breast cancer cells: Potential mechanisms of action
    • Kampa M, Alexaki VI, Notas G, et al. Antiproliferative and apoptotic effects of selective phenolic acids on TD47 human breast cancer cells: potential mechanisms of action. Breast Cancer Res. 2004;6:63-74.
    • (2004) Breast Cancer Res , vol.6 , pp. 63-74
    • Kampa, M.1    Alexaki, V.I.2    Notas, G.3
  • 64
    • 33747043799 scopus 로고    scopus 로고
    • Protocatechuic acid suppresses MPP+-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells
    • Guan S, Jiang B, Bao YM, et al. Protocatechuic acid suppresses MPP+-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food Chem Toxicol. 2006;44:1659-1666.
    • (2006) Food Chem Toxicol , vol.44 , pp. 1659-1666
    • Guan, S.1    Jiang, B.2    Bao, Y.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.