TMEM16A/B associated CaCC: Structural and functional insights

Protein and Peptide Letters

Volumn 21, Issue 1, 2014, Pages 94-99

  Pang, Chunli ^a   Yuan, Hongbo ^a   Ren, Shuxi ^a   Chen, Yafei ^a   An, Hailong ^a   Zhan, Yong ^a  

^a HEBEI UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Ca2+ binding site; CaCCs; Calmodulin; TMEM16A B

Indexed keywords

CALCIUM; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALMODULIN; MEMBRANE PROTEIN; TRANSMEMBRANE PROTEIN 16A; TRANSMEMBRANE PROTEIN 16B; TRANSMEMBRANE PROTEIN 16C; TRANSMEMBRANE PROTEIN 16D; TRANSMEMBRANE PROTEIN 16E; TRANSMEMBRANE PROTEIN 16F; TRANSMEMBRANE PROTEIN 16G; TRANSMEMBRANE PROTEIN 16H; TRANSMEMBRANE PROTEIN 16J; TRANSMEMBRANE PROTEIN 16K; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CALCIUM BINDING; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHLORIDE CHANNELOPATHY; HUMAN; NEOPLASM; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CALMODULIN; CHLORIDE CHANNELS; HUMANS; ION TRANSPORT; MEMBRANE PROTEINS; NEOPLASM PROTEINS; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891405859     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/09298665113206660098     Document Type: Article

References (38)

1. 2+-activated Clchannels. J. Physiol., 2009, 587, 2127-2139.
2. Katoh, M. Identification and characterization of TMEM16E and TMEM16F genes in silico. Int. J. Oncol., 2004, 24,1345-1349.
3. Katoh, M. Characterization of human TMEM16G gene in silico. Int. J. Mol. Med., 2004, 14, 759-764.
4. Katoh, M. Identification and characterization of TMEM16H gene in silico. Int. J. Mol. Med., 2005, 15, 353-358.
5. Schroeder, B. C.; Cheng, T,; Jan, Y.N.; Jan, L.Y. Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell, 2008, 134, 1019-1029.
6. Yang, Y. D.; Cho, H.; Koo, J. Y.; Tak, M. H.; Cho, Y.; Shim, W. S.; Park, S. P.; Lee, J.; Lee, B.; Kim, B. M.; Raouf, R.; Shin, Y. K.; Oh, U. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature, 2008, 455, 1210-1215.
7. Caputo, A.; Caci, E.; Ferrera, L.; Pedemonte, N.; Barsanti, C.; Sondo, E.; Pfeffer, U.; Ravazzolo, R.; Zegarra-Moran, O.; Galietta, L. J. TMEM16A, a membrane protein associated with calciumdependent chloride channel activity. Science, 2008, 322, 590-594.
8. Pifferi S, Dibattista M, Menini A. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch., 2009, 458, 1023-1038.
9. Stephan, A. B.; Shum, E. Y.; Hirsh, S.; Cygnar, K. D.; Reisert, J.; Zhao, H. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc. Natl. Acad. Sci. USA, 2009, 106, 11776-11781.
10. Stohr, H.; Heisig, J. B.; Benz, P. M.; Schoberl, S.; Milenkovic, V. M.; Strauss, O.; Aartsen, W. M.; Wijnholds, J.; Weber, B. H.; Schulz, H. L. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J. Neurosci., 2009, 29, 6809-6818.
11. Planells-Cases, R.; Jentsch, T. J. Chloride channelopathies. Biochim. Biophys. Acta, 2009, 1792, 173-189.
12. Duran, C.; Hartzell, H. C. Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? Acta Pharmacol. Sin., 2011, 32, 685-692.
13. Galindo, B. E.; Vacquier, V. D. Phylogeny of the TMEM16 protein family: some members are overexpressed in cancer. Int. J. Mol. Med., 2005, 16, 919-924.
14. Huang, F.; Rock, J. R.; Harfe, B. D.; Cheng, T.; Huang, X.; Jan, Y. N.; Jan, L. Y;. Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc. Natl. Acad. Sci. USA, 2009, 106, 21413-21418.
15. Rasche, S.; Toetter, B.; Adler, J.; Tschapek, A.; Doerner, J. F.; Kurtenbach, S.; Hatt, H.; Meyer, H.; Warscheid, B.; Neuhaus, E. M. Tmem16b is specifically expressed in the cilia of olfactory sensory neurons. Chem. Senses, 2010, 35, 239-245.
16. Flores, C. A.; Cid, L. P.; Sepulveda, F. V.; Niemeyer, M.I. TMEM16 proteins: the long awaited calcium-activated chloride channels? Braz. J. Med. Biol. Res., 2009, 42, 993-1001.
17. Galietta, L. J. The TMEM16 protein family: a new class of chloride channels? Biophys. J., 2009, 97, 3047-3053.
18. Huang, F.; Wong, X.; Jan, L. Y. International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol. Rev., 2012, 64, 1-15.
19. Hartzell, C.; Putzier, I.; Arreola, J. Calcium-activated chloride channels. Annu. Rev. Physiol., 2005, 67, 719-758.
20. Manoury, B.; Tamuleviciute, A.; Tammaro, P. TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J. Physiol., 2010, 588, 2305-2314.
21. Das, S.; Hahn, Y.; Walker, D. A.; Nagata, S.; Willingham, M. C.; Peehl, D. M.; Bera, T. K.; Lee, B.; Pastan, I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Res., 2008, 68, 6306-6312.
22. Yu, K.; Duran, C.; Qu, Z.; Cui, Y. Y. Hartzell HC. Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ. Res., 2012, 110, 990-999.
23. Sheridan, J. T.; Worthington, E. N.; Yu, K.; Gabriel, S. E.; Hartzell, H. C.; Tarran, R. Characterization of the oligomeric structure of the Ca(2+)-activated Cl-channel Ano1/TMEM16A. J. Biol. Chem., 2011, 286, 1381-1388.
24. Scudieri, P.; Sondo, E.; Caci, E.; Ravazzolo, R.; Galietta, L. J. TMEM16A-TMEM16B chimeras to investigate the structurefunction relationship of calcium-activated chloride channels. Biochem. J., 2013.452,433-455
25. Tien, J.; Lee, H. Y.; Minor, D. L. Jr.; Jan, Y. N.; Jan, L. Y. Identification of a dimerization domain in the TMEM16A calciumactivated chloride channel (CaCC). Proc. Natl. Acad. Sci. USA, 2013, 110, 6352-6357.
26. Xiao, Q.; Yu, K.; Perez-Cornejo, P.; Cui, Y.; Arreola, J.; Hartzell, H. C. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop. Proc. Natl. Acad. Sci. USA, 2011, 108, 8891-8896.
27. Cenedese, V.; Betto, G.; Celsi, F.; Cherian, O. L.; Pifferi, S.; Menini, A. The voltage dependence of the TMEM16B/anoctamin2 calcium-activated chloride channel is modified by mutations in the first putative intracellular loop. J. Gen. Physiol., 2012, 139, 285-294.
28. Ferrera, L.; Scudieri, P.; Sondo, E.; Caputo, A.; Caci, E.; Zegarra-Moran, O.; Ravazzolo, R.; Galietta, L. J. A minimal isoform of the TMEM16A protein associated with chloride channel activity. Biochim. Biophys. Acta, 2011, 1808, 2214-2223.
29. Ferrera, L.; Caputo, A.; Ubby, I.; Bussani, E.; Zegarra-Moran, O.; Ravazzolo, R.; Pagani, F.; Galietta, L. J. Regulation of TMEM16A chloride channel properties by alternative splicing. J. Biol. Chem., 2009, 284, 33360-33368.
30. Lee, U.S.; Cui, J. BK channel activation: structural and functional insights. Trends Neurosci., 2010, 33, 415-423.
31. Tian, Y.; Kongsuphol, P.; Hug, M.; Ousingsawat, J.; Witzgall, R.; Schreiber, R.; Kunzelmann, K. Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J., 2011, 25, 1058-1068.
32. + channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim. Biophys. Acta, 2004, 1665, 1-5.
33. Chen, Y.; An, H.; Li, T.; Liu, Y.; Gao, C.; Guo, P.; Zhang, H.; Zhan, Y. Direct or indirect regulation of calcium-activated chloride channel by calcium. J. Membr. Biol., 2011. 240, 121-129.
34. Jung, J.; Nam, J. H.; Park, H. W.; Oh, U.; Yoon, J. H.; Lee, M. G. Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin. Proc. Natl. Acad. Sci. USA, 2013, 110, 360-365.
35. Terashima, H.; Picollo, A.; Accardi, A. Purification and Functional Reconstitution of the TMEM16A Ca2+ Activated Cl- Channel. Biophys. J., 2013, 104, 648.
36. Yu, K.; Qu, Z.; Zhu, J.; Cui, Y.; Hartzell, H. C. ANO1 Activation does not require Calmodulin. Biophys J., 2013, 104, 474.
37. Namkung, W.; Phuan, P. W.; Verkman, A. S. TMEM16A inhibitors reveal TMEM16A as a minor component of calciumactivated chloride channel conductance in airway and intestinal epithelial cells. J. Biol. Chem., 2011, 286, 2365-2374.
38. Namkung, W.; Yao, Z.; Finkbeiner, W. E.; Verkman, A. S. Smallmolecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J., 2011, 25, 4048-4062.