메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS STIMULATING PROTEIN OF P53 2 PROTEIN; BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 84891399680     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082022     Document Type: Article
Times cited : (14)

References (21)
  • 1
    • 30644473641 scopus 로고    scopus 로고
    • Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies
    • PubMed: 15923428
    • Russo A, Bazan V, Agnese V, Rodolico V, Gebbia N (2005) Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. Ann Oncol 16 Suppl 4: iv44-iv49. PubMed: 15923428.
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 4
    • Russo, A.1    Bazan, V.2    Agnese, V.3    Rodolico, V.4    Gebbia, N.5
  • 2
    • 84874949078 scopus 로고    scopus 로고
    • ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
    • doi:10.1038/cdd.2013.3. PubMed: 23392125
    • Wang Y, Godin-Heymann N, Dan Wang X, Bergamaschi D, Llanos S et al. (2013) ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells. Cell Death Differ 20: 525-534. doi:10.1038/cdd.2013.3. PubMed: 23392125.
    • (2013) Cell Death Differ , vol.20 , pp. 525-534
    • Wang, Y.1    Godin-Heymann, N.2    Dan Wang, X.3    Bergamaschi, D.4    Llanos, S.5
  • 3
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • doi:10.1080/02699050500284218. PubMed: 16393692
    • Yoon S, Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44. doi:10.1080/02699050500284218. PubMed: 16393692.
    • (2006) Growth Factors , vol.24 , pp. 21-44
    • Yoon, S.1    Seger, R.2
  • 4
    • 79952435349 scopus 로고    scopus 로고
    • Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
    • doi:10.1128/MMBR.00031-10. PubMed: 21372320
    • Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75: 50-83. doi:10.1128/MMBR.00031-10. PubMed: 21372320.
    • (2011) Microbiol Mol Biol Rev , vol.75 , pp. 50-83
    • Cargnello, M.1    Roux, P.P.2
  • 5
    • 33644555840 scopus 로고    scopus 로고
    • ASPP [corrected] and cancer
    • doi:10.1038/nrc1818. PubMed: 16498444
    • Trigiante G, Lu X (2006) ASPP [corrected] and cancer. Nat Rev Cancer 6: 217-226. doi:10.1038/nrc1818. PubMed: 16498444.
    • (2006) Nat Rev Cancer , vol.6 , pp. 217-226
    • Trigiante, G.1    Lu, X.2
  • 6
    • 84871946420 scopus 로고    scopus 로고
    • N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence
    • doi:10.1073/pnas.1201514110. PubMed: 23248303
    • Wang Z, Liu Y, Takahashi M, Van Hook K, Kampa-Schittenhelm KM et al. (2013) N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proc Natl Acad Sci U S A 110: 312-317. doi:10.1073/pnas.1201514110. PubMed: 23248303.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 312-317
    • Wang, Z.1    Liu, Y.2    Takahashi, M.3    Van Hook, K.4    Kampa-Schittenhelm, K.M.5
  • 7
    • 77954943975 scopus 로고    scopus 로고
    • ASPP2 regulates epithelial cell polarity through the PAR complex
    • doi:10.1016/j.cub.2010.06.024. PubMed: 20619648
    • Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K et al. (2010) ASPP2 regulates epithelial cell polarity through the PAR complex. Curr Biol 20: 1408-1414. doi:10.1016/j.cub.2010.06.024. PubMed: 20619648.
    • (2010) Curr Biol , vol.20 , pp. 1408-1414
    • Cong, W.1    Hirose, T.2    Harita, Y.3    Yamashita, A.4    Mizuno, K.5
  • 8
    • 77954905229 scopus 로고    scopus 로고
    • ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development
    • doi: 10.1016/j.devcel.2010.06.003. PubMed: 20619750
    • Sottocornola R, Royer C, Vives V, Tordella L, Zhong S et al. (2010) ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. Dev Cell 19: 126-137. doi: 10.1016/j.devcel.2010.06.003. PubMed: 20619750.
    • (2010) Dev Cell , vol.19 , pp. 126-137
    • Sottocornola, R.1    Royer, C.2    Vives, V.3    Tordella, L.4    Zhong, S.5
  • 9
    • 17944379798 scopus 로고    scopus 로고
    • ASPP proteins specifically stimulate the apoptotic function of p53
    • doi:10.1016/S1097-2765(01)00367-7. PubMed: 11684014
    • Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 8: 781-794. doi:10.1016/S1097-2765(01)00367-7. PubMed: 11684014.
    • (2001) Mol Cell , vol.8 , pp. 781-794
    • Samuels-Lev, Y.1    O'Connor, D.J.2    Bergamaschi, D.3    Trigiante, G.4    Hsieh, J.K.5
  • 10
    • 84865191462 scopus 로고    scopus 로고
    • Autophagic activity dictates the cellular response to oncogenic RAS
    • doi:10.1073/pnas.1120193109. PubMed: 22847423
    • Wang Y, Wang XD, Lapi E, Sullivan A, Jia W et al. (2012) Autophagic activity dictates the cellular response to oncogenic RAS. Proc Natl Acad Sci U S A 109: 13325-13330. doi:10.1073/pnas.1120193109. PubMed: 22847423.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 13325-13330
    • Wang, Y.1    Wang, X.D.2    Lapi, E.3    Sullivan, A.4    Jia, W.5
  • 11
    • 77955918876 scopus 로고    scopus 로고
    • Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells
    • doi:10.1038/onc.2010.218. PubMed: 20562906
    • Wang Y, Ngo VN, Marani M, Yang Y, Wright G et al. (2010) Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene 29: 4658-4670. doi:10.1038/onc.2010.218. PubMed: 20562906.
    • (2010) Oncogene , vol.29 , pp. 4658-4670
    • Wang, Y.1    Ngo, V.N.2    Marani, M.3    Yang, Y.4    Wright, G.5
  • 12
    • 0036499467 scopus 로고    scopus 로고
    • Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
    • doi:10.1042/0264-6021:3620481. PubMed: 11853558
    • Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N et al. (2002) Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J 362: 481-490. doi:10.1042/0264-6021: 3620481. PubMed: 11853558.
    • (2002) Biochem J , vol.362 , pp. 481-490
    • Sapkota, G.P.1    Boudeau, J.2    Deak, M.3    Kieloch, A.4    Morrice, N.5
  • 13
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • doi:10.1038/nri979. PubMed: 12509763
    • Downward J (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3: 11-22. doi:10.1038/nri979. PubMed: 12509763.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 14
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • doi: 10.1158/1535-7163.MCT-04-0297. PubMed: 15827342
    • Sridhar SS, Hedley D, Siu LL (2005) Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 4: 677-685. doi: 10.1158/1535-7163.MCT-04-0297. PubMed: 15827342.
    • (2005) Mol Cancer Ther , vol.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 15
    • 33646578801 scopus 로고    scopus 로고
    • ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
    • doi:10.1101/gad.374006. PubMed: 16702401
    • Vives V, Su J, Zhong S, Ratnayaka I, Slee E et al. (2006) ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev 20: 1262-1267. doi:10.1101/gad.374006. PubMed: 16702401.
    • (2006) Genes Dev , vol.20 , pp. 1262-1267
    • Vives, V.1    Su, J.2    Zhong, S.3    Ratnayaka, I.4    Slee, E.5
  • 16
    • 63149117341 scopus 로고    scopus 로고
    • Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
    • doi:10.1073/pnas.0809080106. PubMed: 19251665
    • Kampa KM, Acoba JD, Chen D, Gay J, Lee H et al. (2009) Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A 106: 4390-4395. doi:10.1073/pnas.0809080106. PubMed: 19251665.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4390-4395
    • Kampa, K.M.1    Acoba, J.D.2    Chen, D.3    Gay, J.4    Lee, H.5
  • 17
    • 73449083762 scopus 로고    scopus 로고
    • Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
    • doi:10.1002/hep.23247. PubMed: 20034025
    • Zhao J, Wu G, Bu F, Lu B, Liang A et al. (2010) Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. Hepatology 51: 142-153. doi:10.1002/hep.23247. PubMed: 20034025.
    • (2010) Hepatology , vol.51 , pp. 142-153
    • Zhao, J.1    Wu, G.2    Bu, F.3    Lu, B.4    Liang, A.5
  • 18
    • 14844321860 scopus 로고    scopus 로고
    • Downregulated mRNA expression of ASPP and the hypermethylation of the 5′- untranslated region in cancer cell lines retaining wild-type p53
    • doi:10.1016/j.febslet.2005.01.069. PubMed: 15757645
    • Liu ZJ, Lu X, Zhang Y, Zhong S, Gu SZ et al. (2005) Downregulated mRNA expression of ASPP and the hypermethylation of the 5′- untranslated region in cancer cell lines retaining wild-type p53. FEBS Lett 579: 1587-1590. doi:10.1016/j.febslet.2005.01.069. PubMed: 15757645.
    • (2005) FEBS Lett , vol.579 , pp. 1587-1590
    • Liu, Z.J.1    Lu, X.2    Zhang, Y.3    Zhong, S.4    Gu, S.Z.5
  • 19
    • 4344685735 scopus 로고    scopus 로고
    • Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly
    • doi:10.1016/j.molcel.2004.06.043. PubMed: 15327775
    • Sarraf SA, Stancheva I (2004) Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol Cell 15: 595-605. doi:10.1016/j.molcel.2004.06.043. PubMed: 15327775.
    • (2004) Mol Cell , vol.15 , pp. 595-605
    • Sarraf, S.A.1    Stancheva, I.2
  • 20
    • 1842854235 scopus 로고    scopus 로고
    • Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: Correlation with clinical outcome
    • doi:10.1080/1042819021000040017. PubMed: 12613517
    • Lossos IS, Natkunam Y, Levy R, Lopez CD (2002) Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome. Leuk Lymphoma 43: 2309-2317. doi:10.1080/1042819021000040017. PubMed: 12613517.
    • (2002) Leuk Lymphoma , vol.43 , pp. 2309-2317
    • Lossos, I.S.1    Natkunam, Y.2    Levy, R.3    Lopez, C.D.4
  • 21
    • 0033571118 scopus 로고    scopus 로고
    • In vivo gene expression profile analysis of human breast cancer progression
    • PubMed: 10582678
    • Sgroi DC, Teng S, Robinson G, LeVangie R, Hudson JR Jr. et al. (1999) In vivo gene expression profile analysis of human breast cancer progression. Cancer Res 59: 5656-5661. PubMed: 10582678.
    • (1999) Cancer Res , vol.59 , pp. 5656-5661
    • Sgroi, D.C.1    Teng, S.2    Robinson, G.3    LeVangie, R.4    Hudson Jr., J.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.