ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 1, 2014, Pages 80-90

  Wang, Chunxia ^a   Li, Houkai ^a   Meng, Qingshu ^a   Du, Ying ^a   Xiao, Fei ^a   Zhang, Qian ^a   Yu, Junjie ^a   Li, Kai ^a   Chen, Shanghai ^a   Huang, Zhiying ^a   Liu, Bin ^a   Guo, Feifan ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

ATF4; CYP2E1; Oxidative stress; Primary hepatocytes; ROS; TG accumulation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ATF4 PROTEIN, MOUSE; CREB1 PROTEIN, MOUSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450 2E1; PALMITIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

129 MOUSE; ANIMAL; ARTICLE; ATF4; C57BL MOUSE; ENZYME REPRESSION; ENZYMOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; LIPID DIET; LIVER; LIVER CELL; MALE; METABOLISM; MOUSE; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; PRIMARY HEPATOCYTES; PROMOTER REGION; PROTEIN PROCESSING; ROS; TG ACCUMULATION;

ATF4; CYP2E1; OXIDATIVE STRESS; PRIMARY HEPATOCYTES; ROS; TG ACCUMULATION;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOCHROME P-450 CYP2E1; DIET, HIGH-FAT; ENZYME REPRESSION; HEK293 CELLS; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PALMITATES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; TRIGLYCERIDES;

EID: 84891373634     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12166     Document Type: Article

References (47)

1. Vallejo M, Ron D, Miller CP, et al. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci USA. 1993; 90: 4679-83.
2. Mamady H, Storey KB. Coping with the stress: expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels. Arch Biochem Biophys. 2008; 477: 77-85.
3. Bartsch D, Ghirardi M, Casadio A, et al. Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB1 and CREB2. Cell. 2000; 103: 595-608.
4. Mohamed HA, Yao W, Fioravante D, et al. cAMP-response elements in Aplysia creb1, creb2, and Ap-uch promoters: implications for feedback loops modulating long term memory. J Biol Chem. 2005; 280: 27035-43.
5. Yang X, Matsuda K, Bialek P, et al. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004; 117: 387-98.
6. Seo J, Fortuno ES, Suh JM, et al. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 2009; 58: 2565-73.
7. Harding HP, Zhang Y, Zeng H, et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003; 11: 619-33.
8. Lange PS, Chavez JC, Pinto JT, et al. ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. J Exp Med. 2008; 205: 1227-42.
9. Ord D, Meerits K, Ord T. TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4. Exp Cell Res. 2007; 313: 3556-67.
10. Wang C, Huang Z, Du Y, et al. ATF4 regulates lipid metabolism and thermogenesis. Cell Res. 2010; 20: 174-84.
11. Li H, Meng Q, Xiao F, et al. ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis. Biochem J. 2011; 438: 283-9.
12. Ye J, Koumenis C. ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis. Curr Mol Med. 2009; 9: 411-6.
13. Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011; 54: 795-809.
14. Schaap FG, Kremer AE, Lamers WH, et al. Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie. 2013; 95: 692-9.
15. Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 2009; 58: 250-9.
16. Lin MC, Kao SH, Chung PJ, et al. Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf. J Agric Food Chem. 2009; 57: 5925-32.
17. Matsuzawa-Nagata N, Takamura T, Ando H, et al. Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Metabolism. 2008; 57: 1071-7.
18. Oliveira CP, Coelho AM, Barbeiro HV, et al. Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease. Braz J Med Biol Res. 2006; 39: 189-94.
19. Gawrieh S, Opara EC, Koch TR. Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies. J Investig Med. 2004; 52: 506-14.
20. Patrick L. Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. Altern Med Rev. 2002; 7: 276-91.
21. Masuoka HC, Townes TM. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 2002; 99: 736-45.
22. Zhou L, Li Y, Nie T, et al. Clenbuterol inhibits SREBP-1c expression by activating CREB1. J Biochem Mol Biol. 2007; 40: 525-31.
23. He CH, Gong P, Hu B, et al. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem. 2001; 276: 20858-65.
24. Fl C. Histotechnology: a self-instructional text. 2nd ed. Chicago, IL: American Society for Clinical Pathology Press, 1997.
25. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957; 226: 497-509.
26. Niziolek M, Korytowski W, Girotti AW. Nitric oxide-induced resistance to lethal photooxidative damage in a breast tumor cell line. Free Radic Biol Med. 2006; 40: 1323-31.
27. Wang Q, Jiang L, Wang J, et al. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 2009; 49: 1166-75.
28. Nakamura S, Takamura T, Matsuzawa-Nagata N, et al. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J Biol Chem. 2009; 284: 14809-18.
29. Sato K, Cho Y, Tachibana S, et al. Impairment of VLDL secretion by medium-chain fatty acids in chicken primary hepatocytes is affected by the chain length. J Nutr. 2005; 135: 1636-41.
30. Hong JH, Lee IS. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chem Biol Interact. 2009; 179: 88-93.
31. Malinska H, Oliyarnyk O, Hubova M, et al. Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis. Mol Cell Biochem. 2010; 335: 119-25.
32. Pompella A, Visvikis A, Paolicchi A, et al. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol. 2003; 66: 1499-503.
33. Levin ED. Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging. Curr Alzheimer Res. 2005; 2: 191-6.
34. Kathirvel E, Chen P, Morgan K, et al. Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver. J Gastroenterol Hepatol. 2010; 25: 1136-43.
35. Serviddio G, Sastre J, Bellanti F, et al. Mitochondrial involvement in non-alcoholic steatohepatitis. Mol Aspects Med. 2008; 29: 22-35.
36. Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol. 2004; 44: 27-42.
37. Karamitri A, Shore AM, Docherty K, et al. Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes. J Biol Chem. 2009; 284: 20738-52.
38. Reicks MM, Crankshaw DL. Modulation of rat hepatic cytochrome P-450 activity by garlic organosulfur compounds. Nutr Cancer. 1996; 25: 241-8.
39. Lieber CS, Leo MA, Mak KM, et al. Model of nonalcoholic steatohepatitis. Am J Clin Nutr. 2004; 79: 502-9.
40. Cherasse Y, Maurin AC, Chaveroux C, et al. The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP. Nucleic Acids Res. 2007; 35: 5954-65.
41. Karpinski BA, Morle GD, Huggenvik J, et al. Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci USA. 1992; 89: 4820-4.
42. Bartsch D, Ghirardi M, Skehel PA, et al. Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell. 1995; 83: 979-92.
43. Bujanda L, Hijona E, Larzabal M, et al. Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol. 2008; 8: 40.
44. Mantena SK, Vaughn DP, Andringa KK, et al. High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo. Biochem J. 2009; 417: 183-93.
45. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82: 47-95.
46. Magne L, Blanc E, Legrand B, et al. ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes. J Hepatol. 2011; 54: 729-37.
47. Abdelmegeed MA, Yoo SH, Henderson LE, et al. PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. J Nutr. 2011; 141: 603-10.