Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis

Cardiovascular Research

Volumn 101, Issue 1, 2014, Pages 138-144

  Tano, Jean Yves ^a   Solanki, Sumeet ^a   Lee, Robert H ^a   Smedlund, Kathryn ^a   Birnbaumer, Lutz ^b   Vazquez, Guillermo ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Atherosclerosis; Calcium channels; Macrophage apoptosis; TRPC3 channel

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CATION CHANNEL; COLLAGEN; GELATINASE B; INTERLEUKIN 1BETA; MESSENGER RNA; STAT1 PROTEIN; THAPSIGARGIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; APOPTOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BONE MARROW DEPRESSION; BONE MARROW TRANSPLANTATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFANT; LIPID DIET; MACROPHAGE; MOUSE; MOUSE MODEL; NICK END LABELING; NONHUMAN; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL;

ATHEROSCLEROSIS; CALCIUM CHANNELS; MACROPHAGE APOPTOSIS; TRPC3 CHANNEL;

ANIMALS; AORTA; APOPTOSIS; ATHEROSCLEROSIS; BONE MARROW; DISEASE MODELS, ANIMAL; FEMALE; MACROPHAGES; MICE; NECROSIS; TRPC CATION CHANNELS;

EID: 84891367438     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt231     Document Type: Article

References (27)

1. Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F et al. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation 2009;119:1795-1804.
2. Yancey PG, Blakemore J, Ding L, Fan D, Overton CD, Zhang Y et al. Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol 2010;30:787-795.
3. Seimon TA,Wang Y, Han S, Senokuchi T, Schrijvers DM, KuriakoseG et al. Macrophage deficiency of p38a MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J Clin Invest 2009;119:886-898.
4. Vazquez G,Wedel BJ, Aziz O, Trebak M, Putney J, JamesW. ThemammalianTRPCcation channels. Biochim Biophys Acta Mol Cell Res 2004;1742:21-36.
5. Tano J-Y, Smedlund K, Lee R, Abramowitz J, Birnbaumer L, Vazquez G. Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. Biochem Biophys Res Commun 2011;410:643-647.
6. Tano J-Y, Vazquez G. Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling. Biochem Biophys Res Commun 2011;407:432-437.
7. Smedlund K, Tano J-Y, Vazquez G. The constitutive function of native TRPC3 channels modulates vascular cell adhesion molecule-1 expression in coronary endothelial cells through nuclear factor {kappa}B signaling. Circ Res 2010;106:1479-1488.
8. Tano J-Y, Lee RH, Vazquez G. Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages. Biochem Biophys Res Commun 2012;427:178-184.
9. Thorp E, Cui D, Schrijvers DM, Kuriakose G, Tabas I. Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/-mice. Arterioscler Thromb Vasc Biol 2008;28: 1421-1428.
10. Tabas I. Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 2010;10:36-46.
11. Shearn AIU, Deswaerte V, Gautier EL, Saint-Charles F, Pirault J, Bouchareychas L et al. Bcl-x inactivation in macrophages accelerates progression of advanced atherosclerotic lesions in apoe2/2 mice. Arterioscler Thromb Vasc Biol 2012;32:1142-1149.
12. Zhou J, Lhoták S?, Hilditch BA, Austin RC. Activation of the unfolded protein response occurs at All stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 2005;111:1814-1821.
13. Khallou-Laschet J, Varthaman A, Fornasa G, Compain C, Gaston A-T, Clement M et al. Macrophage plasticity in experimental atherosclerosis. PLoS One 2010;5:e8852.
14. Mantovani A, Garlanda C, Locati M. Macrophage diversity and polarization in atherosclerosis. Arterioscler Thromb Vasc Biol 2009;29:1419-1423.
15. Lim W-S, Timmins JM, Seimon TA, Sadler A, Kolodgie FD, Virmani R et al. Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation 2008;117:940-951.
16. Feng B, Zhang D, Kuriakose G, Devlin CM, Kockx M, Tabas I. Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis. Proc Natl Acad Sci USA 2003;100:10423-10428.
17. Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 2009;29:19-26.
18. Ley K, Miller YI, Hedrick CC. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol 2011;31:1506-1516.
19. LeeCW, Hwang I, Park C-S, Lee H, ParkD-W, Kang S-J et al. Macrophage heterogeneity of culprit coronary plaques in patients with acute myocardial infarction or stable angina. Am J Clin Pathol 2013;139:317-322.
20. Mallavia B, Recio C, Oguiza A, Ortiz-Muñoz G, Lazaro I, Lopez-Parra V et al. Peptide inhibitor of NF-kB translocation ameliorates experimental atherosclerosis. Am J Pathol 2013;182:1910-1921.
21. Kazeros A, Harvey B-G, Carolan BJ, Vanni H, Krause A, Crystal RG. Overexpression of apoptotic cell removal receptor MERTK in alveolar macrophages of cigarette smokers. Am J Respir Cell Mol Biol 2008;39:747-757.
22. Damann N, Owsianik G, Li S, Poll C, Nilius B. The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils. Acta Physiol 2009;195:3-11.
23. Itagaki K, Barton BE, Murphy TF, Taheri S, Shu P, Huang H et al. Eicosanoid-induced store-operated calcium entry in dendritic cells. J Surg Res 2011;169:301-310.
24. Inada H, Iida T, Tominaga M. Different expression patterns of TRP genes in murine B and T lymphocytes. Biochem Biophys Res Commun 2006;350:762-767.
25. Tano JY, Smedlund K, Vazquez G. Endothelial TRPC3/6/7 proteins at the edge of cardiovascular disease. Cardiovasc Hematol Agents Med Chem 2010;8:76-86.
26. Abramowitz J, Birnbaumer L. Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J 2009;23:297-328.
27. Cagnin S, Biscuola M, Patuzzo C, Trabetti E, Pasquali A, Laveder P et al. Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries. BMC Genomics 2009;10:13.