AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells

Food and Chemical Toxicology

Volumn 64, Issue , 2014, Pages 344-352

  Cho, Tae Min ^a   Kim, Wun Jae ^b   Moon, Sung Kwon ^c  

^a Chungju National University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

AKT; Bladder cancer cells; Fucoidan; G1 phase cell cycle arrest; Migration; P21WAF1

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLINE; FUCOIDIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR AP 1; WORTMANNIN;

AKT GENE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

AKT; BLADDER CANCER CELLS; FUCOIDAN; G1-PHASE CELL CYCLE ARREST; MIGRATION; P21WAF1;

ANDROSTADIENES; CELL DIVISION; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; PHOSPHORYLATION; POLYSACCHARIDES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; URINARY BLADDER NEOPLASMS;

EID: 84891365478     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.12.009     Document Type: Article

References (41)

1. Aisa Y., Miyakawa Y., Nakazato T., Shibata H., Saito K., Ikeda Y., Kizaki M. Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways. Am. J. Hematol. 2005, 78(1):7-14.
2. Alekseyenko T.V., Zhanayeva S.Y., Venediktova A.A., Zvyagintseva T.N., Kuznetsova T.A., Besednova N.N., Korolenko T.A. Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga. Bull. Exp. Biol. Med. 2007, 143:730-732.
3. Bianco F.J., Gervasi D.C., Tiguert R., Grignon D.J., Pontes J.E., Crissman J.D., Fridman R., Wood D.P. Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade. Clin. Cancer Res. 1998, 4(12):3011-3016.
4. Boo H.J., Hyun J.H., Kim S.C., Kang J.I., Kim M.K., Kim S.Y., Cho H., Yoo E.S., Kang H.K. Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells. Phytother. Res. 2011, 25(7):1082-1086.
5. Chen L.C., Lee W.S. P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. J. Agric. Food Chem. 2013, 61(11):2811-2819.
6. Chen J., Wang Q., Fu X., Huang X.H., Chen X., Cao L.Q., Chen L.Z., Tan H.X., Li W., Bi J., Zhang L.J. Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9. Hepatol. Res. 2009, 39:177-186.
7. Chromecki T.F., Bensalah K., Remzi M., Verhoest G., Cha E.K., Scherr D.S., Novara G., Karakiewicz P.I., Shariat S.F. Prognostic factors for upper urinary tract urothelial carcinoma. Nat. Rev. Urol. 2011, 8:440-447.
8. Collins K., Jacks T., Pavletich N.P. The cell cycle and cancer. Proc. Natl. Acad. Sci. U.S.A. 1997, 94(7):2776-2778.
9. Davies B., Waxman J., Wasan H., Abel P., Williams G., Krausz T., Neal D., Thomas D., Hanby A., Balkwill F. Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res. 1993, 53:5365-5369.
10. Durig J., Bruhn T., Zurborn K.H., Gutensohn K., Bruhn H.D., Béress L. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb. Res. 1997, 85:479-491.
11. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
12. Harper J.W., Elledge S.J., Keyomarsi K. Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 1995, 6:387-400.
13. Heney N.M., Ahmed S., Flanagar M.J., Frable W., Corder M.P., Hafermann M.D., Hawkins I.R. Superficial bladder cancer: progression and recurrence. J. Urol. 1983, 130:1083-1086.
14. Hill M.M., Hemmings B.A. Inhibition of protein kinase B/AKT implications for cancer therapy. Pharmacol. Ther. 2002, 93:243-251.
15. Itoh H., Noda H., Amano H., Zhuaug C., Mizuno T., Ito H. Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res. 1993, 13:2045-2052.
16. Jacks T., Weinberg R.A. Cell-cycle control and its watchman. Nature 1996, 381(6584):643-644.
17. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010 CA. Cancer J. Clin. 2010, 60:277-300.
18. Jin M.L., Park S.Y., Kim Y.H., Park G., Son H.J., Lee S.J. Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/AKT and ERK-dependent mechanisms. Int. J. Mol. Med. 2012, 29(1):119-124.
19. Lee H., Kim J.S., Kim E. Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-AKT-mTOR pathways. PLoS One 2012, 7(11):e50624.
20. Lee S.J., Cho S.C., Lee E.J., Kim S., Lee S.B., Lim J.H., Choi Y.H., Kim W.J., Moon S.K. Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear factor (NF-κB) activation by inducing the up-regulation of p21(WAF1) protein expression. J. Biol. Chem. 2013, 288(8):5539-5552.
21. Levi F., La Vecchia C., Randimbison L., Franceschi S. Incidence of infiltrating cancer following superficial bladder carcinoma. Int. J. Cancer 1993, 55:419-554.
22. Liotta L.A. Tumor invasion and metastasis-role of extracellular matrix: rhoads memorial award lecture. Cancer Res. 1986, 46:1-7.
23. Macleod K.F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T. P53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 1995, 9(8):935-939.
24. Moon S.K., Jung S.Y., Choi Y.H., Lee Y.C., Patterson C., Kim C.H. PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase. J. Cell. Physiol. 2004, 198(2):310-323.
25. Moon S.K., Kim H.M., Lee Y.C., Kim C.H. Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. J. Biol. Chem. 2004, 279(32):33063-33070.
26. Nakamura T., Suzuki H., Wada Y., Kodama T., Doi T. Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-kappaB-dependent signaling pathways through macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 2006, 343:286-294.
27. Nutt J.E., Durkan G.C., Mellon J.K., Lunec J. Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP-9 by epidermal growth factor and its detection in urine. BJU. Int. 2003, 91(1):99-104.
28. Osaki M., Oshimura M., Ito H. PI3K-AKT pathway: its functions and alterations in human cancer. Apoptosis 2004, 9(6):667-676.
29. Raghavan D. Molecular targeting and pharmacogenomics in the management of advanced bladder cancer. Cancer 2003, 97(Suppl. 8):2083-2089.
30. Sarkar F.H., Li Y. Cell signaling pathways altered by natural chemopreventive agents. Mutat. Res. 2004, 555(1-2):53-64.
31. Sato H., Seiki M. Regulatory mechanism of 92kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 1993, 8:395-405.
32. Sherr C.J. G1 phase progression: cycling on cue. Cell 1994, 79(4):551-555.
33. Sherr C.J. Cancer cell cycles. Science 1996, 274(5293):1672-1677.
34. Song G., Ouyang G., Bao S. The activation of AKT/PKB signaling pathway and cell survival. J. Cell Mol. Med. 2005, 9(1):59-71.
35. Taylor J.A., Kuchel G.A. Bladder cancer in the elderly: clinical outcomes, basic mechanisms, and future research direction. Nat. Clin. Pract. Urol. 2009, 6:135-144.
36. Vivanco I., Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
37. Wang J., Zhang Q., Zhang Z., Song H., Li P. Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int. J. Biol. Macromol. 2010, 46:6-12.
38. Xue M., Ge Y., Zhang J., Wang Q., Hou L., Liu Y., Sun L., Li Q. Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo. PLoS One 2012, 7(8):e43483.
39. Xue M., Ge Y., Zhang J., Liu Y., Wang Q., Hou L., Zheng Z. Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling. Nutr. Cancer 2013, 65(3):460-468.
40. Ye J., Li Y., Teruya K., Katakura Y., Ichikawa A., Eto H., Hosoi M., Hosoi M., Nishimoto S., Shirahata S. Enzyme-digested fucoidan extracts derived from seaweed Mozuku of cladosiphon novae-caledoniaekylin inhibit invasion and angiogenesis of tumor cells. Cytotechnology 2005, 47:117-126.
41. Zapopozhets T.S., Besednova N.N., Loenko Iu.N. Antibacterial and immunomodulating activity of fucoidan. Antibiot. Khimioter. 1995, 40:9-13.