Mechanistic modeling identifies drug-uptake history as predictor of tumor drug resistance and nano-carrier-mediated response

ACS Nano

Volumn 7, Issue 12, 2013, Pages 11174-11182

  Pascal, Jennifer ^a   Ashley, Carlee E ^b,c   Wang, Zhihui ^a   Brocato, Terisse A ^d   Butner, Joseph D ^d   Carnes, Eric C ^a,c,d   Koay, Eugene J ^d,g   Brinker, C Jeffrey ^d,e,f,g,h   Cristini, Vittorio ^a,c,d  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c SANDIA NATIONAL LABORATORIES   (United States)

^d SANDIA NATIONAL LABORATORIES   (United States)

^e Center for Biomedical Engineering   (United States)

^f UNIVERSITY OF NEW MEXICO   (United States)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

drug delivery; mathematical modeling; mesoporous silica nanoparticle; pharmacokinetics pharmacodynamics model; protocells

Indexed keywords

CLINICAL APPLICATION; DOSE RESPONSE RELATIONSHIPS; DOSE-RESPONSE CURVES; HEPATOCELLULAR CARCINOMA; MECHANISTIC MODELING; MESOPOROUS SILICA NANOPARTICLES; PANCREATIC ADENOCARCINOMA; PROTOCELLS;

CELL DEATH; CHEMOTHERAPY; DISEASES; DRUG DELIVERY; MATHEMATICAL MODELS; NONLINEAR EQUATIONS; PHARMACODYNAMICS; PLATINUM COMPOUNDS; TUMORS;

DRUG DOSAGE;

CISPLATIN; DEOXYCYTIDINE; DOXORUBICIN; DRUG CARRIER; DRUG DERIVATIVE; FLUOROURACIL; GEMCITABINE; LIPOSOME; NANOPARTICLE;

ARTICLE; CELL DEATH; CHEMISTRY; DRUG RESISTANCE; DRUG SCREENING; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METHODOLOGY; NANOMEDICINE; THEORETICAL MODEL; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; CISPLATIN; DEOXYCYTIDINE; DOXORUBICIN; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FLUOROURACIL; HUMANS; LIPOSOMES; LIVER NEOPLASMS; MODELS, THEORETICAL; NANOMEDICINE; NANOPARTICLES;

EID: 84891359857     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn4048974     Document Type: Article

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