In vitro induction of apoptosis and necrosis by new derivatives of daunorubicin

Anticancer Research

Volumn 33, Issue 10, 2013, Pages 4439-4444

  Stojak, Marta ^a   Mazur, Lidia ^a   Opydo Chanek, Małgorzata ^a   Ukawska, Małgorzatał ^b   Oszczapowicz, Irena ^b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

Apoptosis; Daunorubicin derivatives; Human acute leukemia cells; Mitochondrial membrane potential; Necrosis

Indexed keywords

ANNEXIN; ANTHRACYCLINE; DAUNORUBICIN DERIVATIVE; FORMAMIDINE; MORPHOLINE; PHOSPHATIDYLSERINE; PROPIDIUM IODIDE; TETRAMETHYLRHODAMINE ETHYL ESTER;

APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NECROSIS; PRIORITY JOURNAL;

APOPTOSIS; DAUNORUBICIN DERIVATIVES; HUMAN ACUTE LEUKEMIA CELLS; MITOCHONDRIAL MEMBRANE POTENTIAL; NECROSIS;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DAUNORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NECROSIS;

EID: 84891356854     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Hortobagyi GN: Anthracyclines in the treatment of cancer. An overview. Drugs 54: 1-7, 1997.
2. Nadas J and Sun D: Anthracyclines as effective anticancer agents. Expert Opin Drug Discov 1: 539-548, 2006.
3. Minotti G, Menna P, Salvatorelli E, Cairo G and Gianni L: Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185-229, 2004.
4. Wa̧sowska M, Oszczapowicz I, Wietrzyk J, Opolski A, Madej J, Dzimira S and Oszczapowicz J: Influence of the structure of new anthracycline antibiotics on their biological properties. Anticancer Res 25: 2043-2048, 2005.
5. Wa̧sowska M, Wietrzyk J, Opolski A, Oszczapowicz J and Oszczapowicz I: Effect of structural modification of anthracyclines on the ability to overcome drug resistance of cancer cells. Anticancer Res 26: 2009-2012, 2006.
6. Wa̧sowska-Łukawska M, Wietrzyk J, Opolski A, Oszczapowicz J and Oszczapowicz I: Biological properties of new derivatives of daunorubicin. In Vivo 21: 413-416, 2007.
7. Stojak M, Mazur L, Opydo-Chanek M, Łukawska M and Oszczapowicz I: Effects of structural modifications of daunorubicin on in vitro antileukemic activity. Anticancer Res 32: 5271-5278, 2012.
8. Guimaraes CA and Linden R: Programmed cell deaths. Eur J Biochem 271: 1638-1650, 2004.
9. De Bruin E.C., Medema J.P. 2008. Apoptosis and non-apoptotic deaths in cancer development and treatment response. Cancer Treatment Reviews 34: 737-749.
10. Bialik S, Zalckvar E, Ber Y, Rubinstein AD and Kimchi A: Systems biology analysis of programmed cell death. Trends Biochem Sci 35: 556-564, 2010.
11. Aubry JP, Blaecke A, Lecoanet-Henchoz S, Jeannin P, Herbault N, Caron G, Moine V and Bonnefoy JY: Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 37: 197-204, 1999.
12. Darżynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T and Traganos F: Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis). Cytometry 27: 1-20, 1997.
13. Kroemer G and JC Reed JC: Mitochondrial control of cell death. Nature Med 6: 513-519, 2000.
14. Bras M, Queenan B and Susun SA: Programmed cell death via mitochondria: Different modes of dying. Biochemistry 70: 231-239, 2005.
15. Desagher S and Martiniou JC: Mitochondria as the central point of apoptosis. Trends Cell Biol 10: 369-377, 2000.
16. Ly JD, Grubb DR and Lawen A: The mitochondrial membrane potential (Δψm) in apoptosis; an update. Apoptosis 8: 115-128, 2003.
17. Tsujimoto Y: Apoptosis and necrosis: intracellular ATP level as a determinant for cell death modes. Cell Death Differ 4: 429-434, 1997.
18. Nicotera P, Leist M and Ferrando-May E: Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol Lett 102-103: 139-142, 1998.
19. Nicotera P and Melino G: Regulation of the apoptosis-necrosis switch. Oncogene 23: 2757-2765, 2004.
20. Oszczapowicz I, Wa̧sowska M, Oszczapowicz J, Owoc A, Dominiczak E, Wietrzyk J and Opolski A: New derivatives of anthracycline antibiotics, method of their synthesis, pharmaceutical agents containing them, and their use. Polish Patent 210494, 2005 (in Polish).
21. Wa̧sowska M, Oszczapowicz J, Oszczapowicz I and Owoc A: New method of synthesis of anthracycline antibiotic derivatives. Polish Patent Application P. 381654, 2006 (in Polish).
22. Perry SW, Norman JP, Barbieri J, Brown EB and Gelbard HA: Mitochondrial membrane potential probes and the proton gradient: A practical usage guide. BioTechniques 50: 98-115, 2011.
23. Portugal J, Bataller M and Mansilla S: Cell death pathways in response to antitumor therapy. Tumori 95: 409-421, 2009.