The mechanical consequence of actual bone loss and simulated bone recovery in acute spinal cord injury

Bone

Volumn 60, Issue , 2014, Pages 141-147

  Edwards, W Brent ^a,b   Schnitzer, Thomas J ^c   Troy, Karen L ^b,d  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Worcester Polytechnic Institute   (United States)

Author keywords

Bone fracture; Bone strength; Disuse osteoporosis; Finite element method

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; BONE MINERAL; BONE REMODELING; BONE STRENGTH; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FRAGILITY FRACTURE; HUMAN; MALE; MECHANICAL TORSION; MIDDLE AGED; OSTEOLYSIS; SPINAL CORD INJURY; TIBIA; YOUNG ADULT;

BONE FRACTURE; BONE STRENGTH; DISUSE OSTEOPOROSIS; FINITE ELEMENT METHOD;

BIOMECHANICAL PHENOMENA; BONE RESORPTION; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; MALE; SPINAL CORD INJURIES; TOMOGRAPHY, X-RAY COMPUTED; TORQUE;

EID: 84891353567     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.12.012     Document Type: Article

References (45)

1. Roberts D., Lee W., Cuneo R.C., Wittmann J., Ward G., Flatman R., et al. Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab 1998, 83:415-422.
2. Edwards W.B., Schnitzer T.J., Troy K.L. Bone mineral loss at the proximal femur in acute spinal cord injury. Osteoporos Int 2013, 24:2461-2469.
3. Jiang S.D., Dai L.Y., Jiang L.S. Osteoporosis after spinal cord injury. Osteoporos Int 2006, 17:180-192.
4. Zehnder Y., Luthi M., Michel D., Knecht H., Perrelet R., Neto I., et al. Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic men. Osteoporos Int 2004, 15:180-189.
5. Frisbie J.H. Fractures after myelopathy: the risk quantified. J Spinal Cord Med 1997, 20:66-69.
6. Lazo M.G., Shirazi P., Sam M., Giobbie-Hurder A., Blacconiere M.J., Muppidi M. Osteoporosis and risk of fracture in men with spinal cord injury. Spinal Cord 2001, 39:208-214.
7. Logan W.C., Sloane R., Lyles K.W., Goldstein B., Hoenig H.M. Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury. Arch Phys Med Rehabil 2008, 89:237-243.
8. Ragnarsson K.T., Sell G.H. Lower extremity fractures after spinal cord injury: a retrospective study. Arch Phys Med Rehabil 1981, 62:418-423.
9. Black D.M., Delmas P.D., Eastell R., Reid I.R., Boonen S., Cauley J.A., et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007, 356:1809-1822.
10. Cummings S.R., San Martin J., McClung M.R., Siris E.S., Eastell R., Reid I.R., et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009, 361:756-765.
11. Morse L.R., Battaglino R.A., Stolzmann K.L., Hallett L.D., Waddimba A., Gagnon D., et al. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int 2009, 20:385-392.
12. Biering-Sorensen F., Bohr H.H., Schaadt O.P. Longitudinal study of bone mineral content in the lumbar spine, the forearm and the lower extremities after spinal cord injury. Eur J Clin Invest 1990, 20:330-335.
13. Eser P., Frotzler A., Zehnder Y., Wick L., Knecht H., Denoth J., et al. Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals. Bone 2004, 34:869-880.
14. Garland D.E., Adkins R.H. Bone loss at the knee in spinal cord injury. Top Spinal Cord Inj Rehabil 2001, 6:37-46.
15. Rogers T., Shokes L.K., Woodworth P.H. Pathologic extremity fracture care in spinal cord injury. Top Spinal Cord Inj Rehabil 2005, 11:70-78.
16. Comarr A.E., Hutchinson R.H., Bors E. Extremity fractures of patients with spinal cord injuries. Am J Surg 1962, 103:732-739.
17. Freehafer A.A., Hazel C.M., Becker C.L. Lower extremity fractures in patients with spinal cord injury. Paraplegia 1981, 19:367-372.
18. Keating J.F., Kerr M., Delargy M. Minimal trauma causing fractures in patients with spinal cord injury. Disabil Rehabil 1992, 14:108-109.
19. Martínez A.A., Cuenca J., Herrera A., Domingo J. Late lower extremity fractures in patients with paraplegia. Injury 2002, 33:583-586.
20. Biering-Sorensen F., Bohr H.H., Schaadt O.P. Bone mineral content of the lumbar spine and lower extremities years after spinal cord lesion. Paraplegia 1988, 26:293-301.
21. Garland D.E., Stewart C.A., Adkins R.H., Hu S.S., Rosen C., Liotta F.J., et al. Osteoporosis after spinal cord injury. J Orthop Res 1992, 10:371-378.
22. Dudley-Javoroski S., Shields R.K. Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method. Osteoporos Int 2010, 21:985-995.
23. Frotzler A., Berger M., Knecht H., Eser P. Bone steady-state is established at reduced bone strength after spinal cord injury: a longitudinal study using peripheral quantitative computed tomography (pQCT). Bone 2008, 43:549-555.
24. Rittweger J., Goosey-Tolfrey V.L., Cointry G., Ferretti J.L. Structural analysis of the human tibia in men with spinal cord injury by tomographic (pQCT) serial scans. Bone 2010, 47:511-518.
25. Keaveny T.M., Kopperdahl D.L., Melton L.J., Hoffmann P.F., Amin S., Riggs B.L., et al. Age-dependence of femoral strength in white women and men. J Bone Miner Res 2010, 25:994-1001.
26. Moran de Brito C.M., Battistella L.R., Saito E.T., Sakamoto H. Effect of alendronate on bone mineral density in spinal cord injury patients: a pilot study. Spinal Cord 2005, 43:341-348.
27. de Bruin E.D., Dietz V., Dambacher M.A., Stussi E. Longitudinal changes in bone in men with spinal cord injury. Clin Rehabil 2000, 14:145-152.
28. Lee T.Q., Shapiro T.A., Bell D.M. Biomechanical properties of human tibias in long-term spinal cord injury. J Rehabil Res Dev 1997, 34:295-302.
29. Edwards W.B., Schnitzer T.J., Troy K.L. Torsional stiffness and strength of the proximal tibia are better predicted by finite element models than DXA or QCT. J Biomech 2013, 46:1655-1662.
30. Martin R. Porosity and specific surface in bone. CRC critical reviews in biomedical engineering 1984, 10:179-222. CRC Press, Boca Raton, Fl.
31. Dalstra M., Huiskes R., Odgaard A., van Erning L. Mechanical and textural properties of pelvic trabecular bone. J Biomech 1993, 26:523-535.
32. Marshall L.M., Lang T.F., Lambert L.C., Zmuda J.M., Ensrud K.E., Orwoll E.S., et al. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res 2006, 21:1197-1206.
33. Rho J.Y., Hobatho M.C., Ashman R.B. Relations of mechanical properties to density and CT numbers in human bone. Med Eng Phys 1995, 17:347-355.
34. Rho J.Y. An ultrasonic method for measuring the elastic properties of human tibial cortical and cancellous bone. Ultrasonics 1996, 34:777-783.
35. Bayraktar H.H., Morgan E.F., Niebur G.L., Morris G.E., Wong E.K., Keaveny T.M. Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue. J Biomech 2004, 37:27-35.
36. Rincon-Kohli L., Zysset P.K. Multi-axial mechanical properties of human trabecular bone. Biomech Model Mechanobiol 2009, 8:195-208.
37. Keaveny T.M., Hoffmann P.F., Singh M., Palermo L., Bilezikian J.P., Greenspan S.L., et al. Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res 2008, 23:1974-1982.
38. Edwards W.B., Schnitzer T.J., Troy K.L. Bone mineral and stiffness loss at the distal femur and proximal tibia in acute spinal cord injury. Osteoporos Int 2013, 10.1007/s00198-013-2557-5.
39. Keyak J.H., Koyama A.K., LeBlanc A., Lu Y., Lang T.F. Reduction in proximal femoral strength due to long-duration spaceflight. Bone 2009, 44:449-453.
40. Rittweger J., Simunic B., Bilancio G., De Santo N.G., Cirillo M., Biolo G., et al. Bone loss in the lower leg during 35days of bed rest is predominantly from the cortical compartment. Bone 2009, 44:612-618.
41. Modlesky C.M., Majumdar S., Narasimhan A., Dudley G.A. Trabecular bone microarchitecture is deteriorated in men with spinal cord injury. J Bone Miner Res 2004, 19:48-55.
42. Hu J.H., Ding M., Soballe K., Bechtold J.E., Danielsen C.C., Day J.S., et al. Effects of short-term alendronate treatment on the three-dimensional microstructural, physical, and mechanical properties of dog trabecular bone. Bone 2002, 31:591-597.
43. Guo X.E., Kim C.H. Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation. Bone 2002, 30:404-411.
44. Silva M.J., Gibson L.J. Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in microstructure. Bone 1997, 21:191-199.
45. Pistoia W., van Rietbergen B., Ruegsegger P. Mechanical consequences of different scenarios for simulated bone atrophy and recovery in the distal radius. Bone 2003, 33:937-945.