Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI

Neuroscience Letters

Volumn 560, Issue , 2014, Pages 21-25

  Li, Shuang Shuang ^a   Zhang, Wei Shi ^a   Ji, Dong ^a   Zhou, Ya Lan ^a   Li, Hui ^b   Yang, Jia Le ^b   Xiong, Yuan Chang ^a   Zhang, Yu Qiu ^b   Xu, Hua ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Dexmedetomidine; IL 18; Microglia; Neuropathic pain

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; ALPHA 2A ADRENERGIC RECEPTOR; BIOLOGICAL MARKER; DEXMEDETOMIDINE; IBA 1 PROTEIN; INTERLEUKIN 18; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LUMBAR PUNCTURE; MALE; MICROGLIA; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DORSAL HORN; WESTERN BLOTTING;

DEXMEDETOMIDINE; IL-18; MICROGLIA; NEUROPATHIC PAIN;

ANALGESICS, NON-NARCOTIC; ANIMALS; CELLS, CULTURED; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; DEXMEDETOMIDINE; HYPERALGESIA; INTERLEUKIN-18; MALE; MICROGLIA; PAIN THRESHOLD; PHYSICAL STIMULATION; POSTERIOR HORN CELLS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SPINAL CORD; SPINAL CORD INJURIES; TOUCH;

EID: 84891327587     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.12.012     Document Type: Article

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