Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10132-10141

  Bourbeau, Matthew P ^a   Siegmund, Aaron ^a   Allen, John G ^a   Shu, Hong ^a   Fotsch, Christopher ^a   Bartberger, Michael D ^a   Kim, Ki Won ^a   Komorowski, Renee ^a   Graham, Melissa ^a   Busby, James ^a   Wang, Minghan ^a   Meyer, James ^a   Xu, Yang ^a   Salyers, Kevin ^a   Fielden, Mark ^a   Véniant, Murielle M ^a   Gu, Wei ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE INHIBITOR; ENZYME INHIBITOR; MALONYL COENZYME A; OXADIAZOLE DERIVATIVE; PHENOXYETHER ANALOGUE; PIPERAZINE DERIVATIVE; TRIFLUOROMETHYLPIPERAZINE OXADIAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIET; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IMPAIRED GLUCOSE TOLERANCE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OBESITY; RAT; STRUCTURE ACTIVITY RELATION;

EID: 84891306680     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401601s     Document Type: Article

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