Remote ischemic preconditioning with - But not without - Metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury

International Journal of Cardiology

Volumn 170, Issue 3, 2014, Pages 388-393

  Schmidt, Michael R ^a   Støttrup, Nicolaj B ^a   Contractor, Hussain ^b   Hyldebrandt, Janus A ^a   Johannsen, Mogens ^a   Pedersen, Christian M ^a   Birkler, Rune ^a   Ashrafian, Houman ^b   Sørensen, Keld E ^a   Kharbanda, Rajesh K ^b   Redington, Andrew N ^c   Bøtker, Hans E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b John Radcliffe ^*  (United Kingdom)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Insulin; Ischemia reperfusion injury; Metabolism; Pediatric; Preconditioning

Indexed keywords

LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; FEMALE; GLUCOSE INFUSION; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART PROTECTION; IN VIVO STUDY; INSULIN INFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIMB ISCHEMIA; MALE; MASS SPECTROMETRY; MICRODIALYSIS; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; REMOTE ISCHEMIC PRECONDITIONING; REPERFUSION INJURY; SYSTOLIC BLOOD PRESSURE;

INSULIN; ISCHEMIA-REPERFUSION INJURY; METABOLISM; PEDIATRIC; PRECONDITIONING;

ANIMALS; ANIMALS, NEWBORN; GLUCOSE; HYPOGLYCEMIC AGENTS; INOSINE; INSULIN; ISCHEMIC PRECONDITIONING; LACTIC ACID; MICRODIALYSIS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RANDOM ALLOCATION; SWINE; VENTRICULAR FUNCTION, LEFT;

EID: 84891001466     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.11.020     Document Type: Article

References (30)

1. C. Bull, J. Cooper, and J. Stark Cardioplegic protection of the child's heart J Thorac Cardiovasc Surg 88 1984 287 293
2. P. Julia, H.H. Young, G.D. Buckberg, E.R. Kofsky, and H.I. Bugyi Studies of myocardial protection in the immature heart. II. Evidence for importance of amino acid metabolism in tolerance to ischemia J Thorac Cardiovasc Surg 100 1990 888 895
3. M.M. Cheung, R.K. Kharbanda, and I.E. Konstantinov et al. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans J Am Coll Cardiol 47 2006 2277 2282
4. V. Venugopal, D.J. Hausenloy, and A. Ludman et al. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial Heart 95 2009 1567 1571
5. W.I. Awad, M.J. Shattock, and D.J. Chambers Ischemic preconditioning in immature myocardium Circulation 98 1998 II206 II213
6. B. Ostadal, I. Ostadalova, and N.S. Dhalla Development of cardiac sensitivity to oxygen deficiency: comparative and ontogenetic aspects Physiol Rev 79 1999 635 659
7. Z. Bin, Y. Tiehu, M. Su, and L. Cun Absence of apparent cardioprotection following ischemic preconditioning in immature rabbit hearts Heart Lung Circ 12 2003 39 43
8. B.O. Jones, S. Pepe, and F.L. Sheeran et al. Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial J Thorac Cardiovasc Surg 146 6 2013 1334 1340
9. S. Pepe, N.Y. Liaw, and M. Hepponstall et al. Effect of remote ischemic preconditioning on phosphorylated protein signaling in children undergoing tetralogy of fallot repair: a randomized controlled trial J Am Heart Assoc 2 2013 e000095
10. B. Zhu, S. Min, C. Long, and T. Ye Ischemic preconditioning in immature hearts: mechanism and compatibility with cardioplegia Chin Med J 116 2003 253 257
11. I. Ostadalova, B. Ostadal, F. Kolar, J.R. Parratt, and S. Wilson Tolerance to ischaemia and ischaemic preconditioning in neonatal rat heart J Mol Cell Cardiol 30 1998 857 865
12. K.A. Webster, D.J. Discher, and N.H. Bishopric Cardioprotection in an in vitro model of hypoxic preconditioning J Mol Cell Cardiol 27 1995 453 458
13. I. Ostadalova, B. Ostadal, and F. Kolar Effect of prenatal hypoxia on contractile performance and responsiveness to Ca2 + in the isolated perinatal rat heart Physiol Res Acad Sci Bohemoslov 44 1995 135 137
14. M.R. Schmidt, N.B. Stottrup, and M.M. Michelsen et al. Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart J Thorac Cardiovasc Surg 2013 10.1016/j.jtcvs.2013.05.022
15. R.I. Birkler, N.B. Stottrup, and S. Hermannson et al. A UPLC-MS/MS application for profiling of intermediary energy metabolites in microdialysis samples- A method for high-throughput J Pharm Biomed Anal 53 2010 983 990
16. K. Przyklenk, and P. Whittaker Cardioprotection via adaptation to hypoxia: expanding the timeline and targets? Basic Res Cardiol 106 2011 325 328
17. M.R. Schmidt, S.B. Kristiansen, and P. White et al. Glucose-insulin infusion improves cardiac function during fetal tachycardia J Am Coll Cardiol 43 2004 445 452
18. M.R. Schmidt, M. Smerup, and I.E. Konstantinov et al. Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning Am J Physiol Heart Circ Physiol 292 2007 H1883 H1890
19. Y. Cottin, I. Lhuillier, and L. Gilson et al. Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic cardiomyopathy Eur J Heart Fail 4 2002 181 184
20. F.C. Sasso, O. Carbonara, and D. Cozzolino et al. Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients: a radionuclide ventriculographic study J Am Coll Cardiol 36 2000 219 226
21. R.K. Kharbanda, U.M. Mortensen, and P.A. White et al. Transient limb ischemia induces remote ischemic preconditioning in vivo Circulation 106 2002 2881 2883
22. D.J. Hausenloy, and D.M. Yellon Clinical translation of cardioprotective strategies: report and recommendations of the Hatter Institute 5th International Workshop on Cardioprotection Basic Res Cardiol 103 2008 493 500
23. G. Heusch Cardioprotection: chances and challenges of its translation to the clinic Lancet 381 2013 166 175
24. H.E. Botker, R. Kharbanda, and M.R. Schmidt et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial Lancet 375 2010 727 734
25. S.P. Hoole, P.M. Heck, and L. Sharples et al. Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study: a prospective, randomized control trial Circulation 119 2009 820 827
26. M. Thielmann, E. Kottenberg, and K. Boengler et al. Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest Basic Res Cardiol 105 2010 657 664
27. S. Tamareille, V. Mateus, and N. Ghaboura et al. RISK and SAFE signaling pathway interactions in remote limb ischemic perconditioning in combination with local ischemic postconditioning Basic Res Cardiol 106 2011 1329 1339
28. D.J. Hausenloy, E.K. Iliodromitis, and I. Andreadou et al. Investigating the signal transduction pathways underlying remote ischemic conditioning in the porcine heart Cardiovasc Drugs Ther 26 2012 87 93
29. L. Breivik, E. Helgeland, E.K. Aarnes, J. Mrdalj, and A.K. Jonassen Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion Basic Res Cardiol 106 2011 135 145
30. J.E. Baker, P. Holman, and G.J. Gross Preconditioning in immature rabbit hearts: role of KATP channels Circulation 99 1999 1249 1254