Intraocular/intracranial pressure mismatch hypothesis for visual impairment syndrome in space

Aviation Space and Environmental Medicine

Volumn 85, Issue 1, 2014, Pages 78-80

  Zhang, Li Fan ^a   Hargens, Alan R ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UCSD MEDICAL CENTER   (United States)

Author keywords

ISS; Microgravity adaptation; VIIP syndrome; Visual impairment

Indexed keywords

EID: 84890943048     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: 10.3357/ASEM.3789.2014     Document Type: Article

References (14)

1. Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N, Herault S. Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term headdown tilt and spaceflights. Eur J Appl Physiol 2001; 86: 157-68
2. Davson H, Welch K, Segal MB. Physiology and pathophysiology of the cerebrospinal fluid. New York: Churchill Livingstone, 1987
3. Fogarty JA, Otto C, Kerstman E, Oubre C, Wu J. The Visual Impairment Intracranial Pressure Summit Report. Hanover, MD: NASA Center for AeroSpace Information; 2011; NASA/ TP-2011-216160
4. Goel M, Picciani RG, Lee RK, Bhattacharya SK. Aqueous humor dynamics: a review. Open Ophthalmol J 2010; 4: 52-9
5. Hargens AR, Bhattacharya R, Schneider SM. Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. Eur J Appl Physiol 2013
6. Kergoat H, Lovasik JV. Seven-degree head-down tilt reduces choroidal pulsatile ocular blood flow. Aviat Space Environ Med 2005; 76: 930-4
7. Kramer LA, Sargsyan AE, Hasan KM, Polk JD, Hamilton DR. Orbital and intracranial effects of microgravity: findings at 3-T MR imaging. Radiology 2012; 263: 819-27
8. Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 2011; 118: 2058-69
9. Rowell LB. Human cardiovascular control. New York: Oxford University Press, 1993
10. Shinojima A, Iwasaki K, Akoi K, Ogawa Y, Yanagida R, Yuzawa M. Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt. Aviat Space Environ Med 2012; 83: 388-93.
11. Watenpaugh DE, Hargens AR. The cardiovascular system in microgravity. In: Handbook of physiology: environmental physi ology. New York: American Physiological Society; 1996: 631-74
12. Wiener TC. Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space. Aviat Space Environ Med 2012; 83: 64-6
13. Zhang LF. Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment. Eur J Appl Physiol 2013; 113: 2873-95
14. Zwart SR, Gibson CR, Mader TH, Ericson K, Ploutz-Snyder R et al. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism. J Nutr 2012; 142: 427-31