Feline CKD: Pathophysiology and risk factors - what do we know?

Journal of Feline Medicine and Surgery

Volumn 15, Issue 1 SUPPL., 2013, Pages 3-14

  Reynolds, Brice S ^a   Lefebvre, Hervé P ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL DISEASE; CAT; CAT DISEASE; CHRONIC KIDNEY FAILURE; KIDNEY; PATHOPHYSIOLOGY; REVIEW; RISK FACTOR;

ANIMALS; CAT DISEASES; CATS; KIDNEY; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS;

EID: 84890938237     PISSN: 1098612X     EISSN: 15322750     Source Type: Journal    
DOI: 10.1177/1098612X13495234     Document Type: Review

References (91)

1. Bartges JW.Chronic kidney disease in dogs and cats.Vet Clin North Am Small Anim Pract. 2012;42:669-692.
2. Ross SJ,Osborne CA,Kirk CA,Lowry SR,Koehler LA,Polzin DJ.Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats.J Am Vet Med Assoc. 2006;229:949-957.
3. Lulich JP,Osborne CA,O'Brien RD,Polzin DJ.Feline renal failure: questions, answers, questions.Compend Contin Educ Pract Vet. 1992;14:127-152.
4. Lees GENephrology and urology of small animals. Bartges JPolzin DJ, ed. Ames: Blackwell Publishing; 2011:568-576.
5. White JD,Norris JM,Bosward KL,Fleay R,Lauer C,Malik R.Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats.J Feline Med Surg. 2008;10:219-229.
6. Aresu L,Zanatta R,Pregel P,Caliari D,Tursi M,Valenza F,et al.Bilateral juvenile renal dysplasia in a Norwegian Forest cat.J Feline Med Surg. 2009;11:326-329.
7. Bailiff NL,Westropp JL,Nelson RW,Sykes JE,Owens SD,Kass PH.Evaluation of urine specific gravity and urine sediment as risk factors for urinary tract infections in cats.Vet Clin Pathol. 2008;37:317-322.
8. Kyles AE,Hardie EM,Wooden BG,Adin CA,Stone EA,Gregory CRet al.Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in cats with ureteral calculi: 163 cases (1984-2002).J Am Vet Med Assoc. 2005;226:932-936.
9. Kyles AE,Hardie EM,Wooden BG,Adin CA,Stone EA,Gregory CRet al.Management and outcome of cats with ureteral calculi: 153 cases (1984-2002).J Am Vet Med Assoc. 2005;226:937-944.
10. DiBartola SP,Rutgers HC,Zack PM,Tarr MJ.Clinicopathologic findings associated with chronic renal disease in cats: 74 cases (1973-1984).J Am Vet Med Assoc. 1987;190:1196-1202.
11. Gabor LJ,Canfield PJ,Malik R.Haematological and biochemical findings in cats in Australia with lymphosarcoma.Aust Vet J. 2000;78:456-461.
12. van Hoek I,Daminet S.Interactions between thyroid and kidney function in pathological conditions of these organ systems: a review.Gen Comp Endocrinol. 2009;160:205-215.
13. van Hoek I,Daminet S,Notebaert S,Janssens I,Meyer E.Immunoassay of urinary retinol binding protein as a putative renal marker in cats.J Immunol Methods. 2008;329:208-213.
14. van Hoek I,Lefebvre HP,Peremans K,Meyer E,Croubels S,Vandermeulen Eet al.Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine.Domest Anim Endocrinol. 2009;36:45-56.
15. Williams TL,Peak KJ,Brodbelt D,Elliott J,Syme HM.Survival and the development of azotemia after treatment of hyperthyroid cats.J Vet Intern Med. 2010;24:863-869.
16. Poli A,Tozon N,Guidi G,Pistello M.Renal alterations in feline immunodeficiency virus (FIV)-infected cats: a natural model of lentivirus-induced renal disease changes.Viruses. 2012;4:1372-1389.
17. Glick AD,Horn RG,Holscher M.Characterization of feline glomerulonephritis associated with viral-induced hematopoietic neoplasms.Am J Pathol. 1978;92:321-332.
18. Ishida T,Washizu T,Toriyabe K,Motoyoshi S,Tomoda I,Pedersen NC.Feline immunodeficiency virus infection in cats in Japan.J Am Vet Med Assoc. 1989;194:221-225.
19. Baxter KJ,Levy JK,Edinboro CH,Vaden SL,Tompkins MB.Renal disease in cats infected with feline immunodeficiency virus.J Vet Intern Med. 2012;26:238-243.
20. Woo PC,Lau SK,Wong BH,Fan RY,Wong AY,Zhang AJet al.Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats.Proc Natl Acad Sci USA. 2012;109:5435-5440.
21. Lappin MR,Basaraba RJ,Jensen WA.Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates.J Feline Med Surg. 2006;8:353-356.
22. Whittemore JC,Hawley JR,Jensen WA,Lappin MR.Antibodies against Crandell Rees feline kidney (CRFK) cell line antigens, alpha-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats.J Vet Intern Med. 2010;24:306-313.
23. DiBartola SP,Buffington CA,Chew DJ,McLoughlin MA,Sparks RA.Development of chronic renal disease in cats fed a commercial diet.J Am Vet Med Assoc. 1993;202:744-751.
24. Hughes KL,Slater MR,Geller S,Burkholder WJ,Fitzgerald C.Diet and lifestyle variables as risk factors for chronic renal failure in pet cats.Prev Vet Med. 2002;55:1-15.
25. Reynolds BS,Chetboul V,Nguyen P,Testault I,Concordet D,Carlos Sampedrano Cet al.Effects of dietary salt intake on renal function: a 2 year study in healthy aged cats.J Vet Intern Med. 2013;27:507-515.
26. Elliott J,Barber PJ.Feline chronic renal failure: clinical findings in 80 cases diagnosed between 1992 and 1995.J Small Anim Pract. 1998;39:78-85.
27. Polzin DJNephrology and urology of small animals. Bartges JPolzin DJ, ed. Ames: Wiley-Blackwell; 2011:433-471.
28. Lawler DF,Evans RH,Chase K,Ellersieck M,Li Q,Larson BTet al.The aging feline kidney: a model mortality antagonist?.J Feline Med Surg. 2006;8:363-371.
29. Weiss DJ,Gagne JM,Armstrong PJ.Relationship between inflammatory hepatic disease and inflammatory bowel disease, pancreatitis, and nephritis in cats.J Am Vet Med Assoc. 1996;209:1114-1116.
30. Jepson RE,Brodbelt D,Vallance C,Syme HM,Elliott J.Evaluation of predictors of the development of azotemia in cats.J Vet Intern Med. 2009;23:806-813.
31. Syme HM,Markwell PJ,Pfeiffer D,Elliott J.Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria.J Vet Intern Med. 2006;20:528-535.
32. Buffington CA.Invited commentary on 'The aging feline kidney: a model mortality antagonist?'.J Feline Med Surg. 2006;8:361-362.
33. Boyd LM,Langston C,Thompson K,Zivin K,Imanishi M.Survival in cats with naturally occurring chronic kidney disease (2000-2002).J Vet Intern Med. 2008;22:1111-1117.
34. White JD,Norris JM,Baral RM,Malik R.Naturally-occurring chronic renal disease in Australian cats: a prospective study of 184 cases.Aust Vet J. 2006;84:188-194.
35. Jepson RE.Feline systemic hypertension: classification and pathogenesis.J Feline Med Surg. 2011;13:25-34.
36. Chetboul V,Lefebvre HP,Pinhas C,Clerc B,Boussouf M,Pouchelon JL.Spontaneous feline hypertension: clinical and echocardiographic abnormalities, and survival rate.J Vet Intern Med. 2003;17:89-95.
37. Jepson RE,Elliott J,Brodbelt D,Syme HM.Effect of control of systolic blood pressure on survival in cats with systemic hypertension.J Vet Intern Med. 2007;21:402-409.
38. Chakrabarti S,Syme HM,Brown CA,Elliott J.Histomorphometry of feline chronic kidney disease and correlation with markers of renal dysfunction.Vet Pathol. 2013;50:147-155.
39. Taugner E,Baatz G,Nobiling R.The renin-angiotensin system in cats with chronic renal failure.J Comp Pathol. 1996;115:239-252.
40. Elliott J,Rawlings JM,Markwell PJ,Barber PJ.Survival of cats with naturally occurring chronic renal failure: effect of dietary management.J Small Anim Pract. 2000;41:235-242.
41. Gouni V,Chetboul V,Pouchelon JL,Sampedrano CC,Maurey C,Lefebvre HP.Azotemia in cats with feline hypertrophic cardiomyopathy: prevalence and relationships with echocardiographic variables.J Vet Cardiol. 2008;10:117-123.
42. Javadi S,Djajadiningrat-Laanen SC,Kooistra HS,van Dongen AM,Voorhout G,van Sluijs FJet al.Primary hyperaldosteronism, a mediator of progressive renal disease in cats.Domest Anim Endocrinol. 2005;28:85-104.
43. Andrew R,Harvey AM,Tasker S.Primary hyperaldosteronism in the cat: a series of 13 cases.J Feline Med Surg. 2005;7:173-182.
44. Kelly DF,Lucke VM,McCullagh KG.Experimental pyelonephritis in the cat. 1 Gross and histologic findings.J Comp Pathol. 1979;89:125-139.
45. Mayer-Roenne B,Goldstein RE,Erb HN.Urinary tract infections in cats with hyperthyroidism, diabetes mellitus and chronic kidney disease.J Feline Med Surg. 2007;9:124-132.
46. King JN,Gunn-Moore DA,Tasker S,Gleadhill A,Strehlau G.Benazepril in Renal insufficiency in Cats Study Group. Tolerability and efficacy of benazepril in cats with chronic kidney disease.J Vet Intern Med. 2006;20:1054-1064.
47. Bartges JW,Barsanti JACurrent veterinary therapy. 13th ed.Philadelphia: WB Saunders, 2000, pp 880-882.Kirk RW, ed. Philadelphia: WB Saunders; 2000:880-882.
48. Ichii O,Yabuki A,Sasaki N,Otsuka S,Ohta H,Yamasaki Met al.Pathological correlations between podocyte injuries and renal functions in canine and feline chronic kidney diseases.Histol Histopathol. 2011;26:1243-1255.
49. Vaden SL.Glomerular disease.Top Companion Anim Med. 2011;26:128-134.
50. Sato R,Soeta S,Syuto B,Yamagishi N,Sato J,Naito Y.Urinary excretion of N-acetyl-beta-D-glucosaminidase and its isoenzymes in cats with urinary disease.J Vet Med Sci. 2002;64:367-371.
51. Ross LA,Finco DR.Relationship of selected clinical renal function tests to glomerular filtration rate and renal blood flow in cats.Am J Vet Res. 1981;42:1704-1710.
52. Elliott J,Syme HM,Reubens E,Markwell PJ.Assessment of acid-base status of cats with naturally occurring chronic renal failure.J Small Anim Pract. 2003;44:65-70.
53. King JN,Tasker S,Gunn-Moore DA,Strehlau G.BENRiC (Benazepril in Renal insufficiency in Cats) Study Group. Prognostic factors in cats with chronic kidney disease.J Vet Intern Med. 2007;21:906-916.
54. Liu Y.Cellular and molecular mechanisms of renal fibrosis.Nat Rev Nephrol. 2011;7:684-696.
55. Arata S,Ohmi A,Mizukoshi F,Baba K,Ohno K,Setoguchi A,Tsujimoto H.Urinary transforming growth factor-β1 in feline chronic renal failure.J Vet Med Sci. 2005;67:1253-1255.
56. Sawashima K,Mizuno S,Mizuno-Horikawa Y,Shimada A,Kudo T,Kurosawa T.Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure.Am J Vet Res. 2000;61:1080-1086.
57. Yabuki A,Mitani S,Fujiki M,Misumi K,Endo Y,Miyoshi Net al.Comparative study of chronic kidney disease in dogs and cats: induction of myofibroblasts.Res Vet Sci. 2010;88:294-299.
58. Brown SA.Oxidative stress and chronic kidney disease.Vet Clin North Am Small Anim Pract. 2008;38:157-166.
59. Keegan RF,Webb CB.Oxidative stress and neutrophil function in cats with chronic renal failure.J Vet Intern Med. 2010;24:514-519.
60. Jensen J,Henik RA,Brownfield M,Armstrong J.Plasma renin activity and angiotensin I and aldosterone concentrations in cats with hypertension associated with chronic renal disease.Am J Vet Res. 1997;58:535-540.
61. Mishina M,Watanabe T,Fujii K,Maeda H,Wakao Y,Takahashi M.Non-invasive blood pressure measurements in cats: clinical significance of hypertension associated with chronic renal failure.J Vet Med Sci. 1998;60:805-808.
62. Pedersen KM,Pedersen HD,Häggström J,Koch J,Ersbøll AK.Increased mean arterial pressure and aldosterone-to-renin ratio in Persian cats with polycystic kidney disease.J Vet Intern Med. 2003;17:21-27.
63. Watanabe T,Mishina M.Effects of benazepril hydrochloride in cats with experimentally induced or spontaneously occurring chronic renal failure.J Vet Med Sci. 2007;69:1015-1023.
64. Lefebvre HP,Toutain PL.Angiotensin-converting enzyme inhibitors in the therapy of renal diseases.J Vet Pharmacol Ther. 2004;27:265-281.
65. Brown SA,Brown CA,Jacobs G,Stiles J,Hendi RS,Wilson S.Effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency.Am J Vet Res. 2001;62:375-383.
66. Schrier RW,Masoumi A,Elhassan E.Aldosterone: role in edematous disorders, hypertension, chronic renal failure, and metabolic syndrome.Clin J Am Soc Nephrol. 2010;5:1132-1140.
67. Brown SA,Brown CA.Single-nephron adaptations to partial renal ablation in cats.Am J Physiol. 1995;269:R1002-R1008.
68. Brown SA,Crowell WA,Brown CA,Barsanti JA,Finco DR.Pathophysiology and management of progressive renal disease.Vet J. 1997;154:93-109.
69. Ross LA,Finco DR,Crowell WA.Effect of dietary phosphorus restriction on the kidneys of cats with reduced renal mass.Am J Vet Res. 1982;43:1023-1026.
70. Adams LG,Polzin DJ,Osborne CA,O'Brien TD,Hostetter TH.Influence of dietary protein/calorie intake on renal morphology and function in cats with 5/6 nephrectomy.Lab Invest. 1994;70:347-357.
71. Finco DR,Brown SA,Brown CA,Crowell WA,Sunvold G,Cooper TL.Protein and calorie effects on progression of induced chronic renal failure in cats.Am J Vet Res. 1998;59:575-582.
72. Elliott J,Syme HM,Markwell PJ.Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function.J Small Anim Pract. 2003;44:261-268.
73. Chakrabarti S,Syme HM,Elliott J.Clinicopathological variables predicting progression of azotemia in cats with chronic kidney disease.J Vet Intern Med. 2012;26:275-281.
74. Kuwahara Y,Ohba Y,Kitoh K,Kuwahara N,Kitagawa H.Association of laboratory data and death within one month in cats with chronic renal failure.J Small Anim Pract. 2006;47:446-450.
75. Brown S,Atkins C,Bagley R,Carr A,Cowgill L,Davidson Met al.Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats.J Vet Intern Med. 2007;21:542-558.
76. Kidder A,Chew D.Treatment options for hyperphosphataemia in feline CKD.J Feline Med Surg. 2009;11:913-924.
77. Barber PJ,Elliott J.Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995.J Small Anim Pract. 1998;39:108-116.
78. Finch NC,Geddes RF,Syme HM,Elliott J.Fibroblast growth factor 23 (FGF-23) concentrations in cats with early nonazotemic chronic kidney disease (CKD) and in healthy geriatric cats.J Vet Intern Med. 2013;27:227-233.
79. Geddes RF,Finch NC,Elliott J,Syme HM.Fibroblast growth factor 23 in feline chronic kidney disease.J Vet Intern Med. 2013;27:234-241.
80. Bertazzolo W,Toscani L,Calcaterra S,Crippa L,Caniatti M,Bonfanti U.Clinicopathological findings in five cats with paw calcification.J Feline Med Surg. 2003;5:11-17.
81. DiBartola SP,Autran De Morais HFluid, electrolyte, and acid-base disorders in small animal practice. 4th ed.St Louis: Elsevier Saunders, 2012, pp 92-119.DiBartola SP, ed. St Louis: Elsevier Saunders; 2012:92-119.
82. Dow SW,Fettman MJ,Curtis CR,LeCouteur RA.Hypokalemia in cats: 186 cases (1984-1987).J Am Vet Med Assoc. 1989;194:1604-1608.
83. Adams LG,Polzin DJ,Osborne CA,O'Brien TD.Effects of dietary protein and calorie restriction in clinically normal cats and in cats with surgically induced chronic renal failure.Am J Vet Res. 1993;54:1653-1662.
84. Dow SW,Fettman MJ,Smith KR,Hamar DW,Nagode LA,Refsal KRet al.Effects of dietary acidification and potassium depletion on acid-base balance, mineral metabolism and renal function in adult cats.J Nutr. 1990;120:569-578.
85. Cowgill LD.Pathophysiology and management of anemia in chronic progressive renal failure.Semin Vet Med Surg (Small Anim). 1992;7:175-182.
86. Chalhoub S,Langston C,Eatroff A.Anemia of renal disease: what it is, what to do and what's new.J Feline Med Surg. 2011;13:629-640.
87. Lees GE,Brown SA,Elliott J,Grauer GE,Vaden SL.Assessment and management of proteinuria in dogs and cats: 2004 ACVIM Forum Consensus Statement (small animal).J Vet Intern Med. 2005;19:377-385.
88. Syme HM.Proteinuria in cats. Prognostic marker or mediator?.J Feline Med Surg. 2009;11:211-218.
89. Bartlett PC,Van Buren JW,Bartlett AD,Zhou C.Case-control study of risk factors associated with feline and canine chronic kidney disease.Vet Med Int. 2010;:.
90. Goldstein RE,Marks SL,Kass PH,Cowgill LD.Gastrin concentrations in plasma of cats with chronic renal failure.J Am Vet Med Assoc. 1998;213:826-828.
91. Schulman RL,Krawiec DRKirk's current veterinary therapy. XIII Small animal practice. Bonagura JD, ed. Philadelphia: WB Saunders; 2000:864-866.