Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes

Diabetologia

Volumn 57, Issue 1, 2014, Pages 140-147

  De Leu, Nico ^a   Heremans, Yves ^a   Coppens, Violette ^a   Van Gassen, Naomi ^a   Cai, Ying ^a   D'Hoker, Joke ^a   Magenheim, Judith ^b   Salpeter, Seth ^b   Swisa, Avital ^b   Khalaileh, Abed ^b   Arnold, Carole ^c   Gradwohl, Gerard ^c   Van De Casteele, Mark ^a   Keshet, Eli ^b   Dor, Yuval ^b   Heimberg, Harry ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

^b HEBREW UNIVERSITY   (Israel)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Beta cell proliferation; Beta cell protection; VEGF

Indexed keywords

DOXYCYCLINE; VASCULOTROPIN A;

ADULT ANIMAL; ADULT DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CELL DENSITY; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; IMPAIRED GLUCOSE TOLERANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84890925943     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3076-9     Document Type: Article

References (26)

1. Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294:564-567
2. Brissova M, Shostak A, Shiota M et al (2006) Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularisation, revascularisation, and function. Diabetes 55:2974-2985
3. Jacquemin P, Yoshitomi H, Kashima Y, Rousseau G, Lemaigre F, Zaret K (2006) An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290:189-199
4. Nikolova G, Jabs N, Konstantinova I et al (2006) The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation. Dev Cell 10:397-405
5. Pierreux CE, Cordi S, Hick A-C et al (2010) Epithelial: endothelial cross-talk regulates exocrine differentiation in developing pancreas. Dev Biol 347:216-227
6. Yoshitomi H, Zaret KS (2004) Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131:807-817
7. Lammert E, Gu G, McLaughlin M et al (2003) Role of VEGF-A in vascularisation of pancreatic islets. Curr Biol 13:1070-1074
8. Magenheim J, Ilovich O, Lazarus A et al (2011) Blood vessels restrain pancreas branching, differentiation and growth. Development 138:4743-4752
9. Cleaver O, Dor Y (2012) Vascular instruction of pancreas development. Development 139:2833-2843
10. Kaido T, Yebra M, Cirulli V, Montgomery AM (2004) Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J Biol Chem 279:53762-53769
11. Johansson M (2006) Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats. Endocrinology 147:2315-2324
12. Agudo J, Ayuso E, Jimenez V et al (2012) Vascular endothelial growth factor-mediated islet hypervascularisation and inflammation contribute to progressive reduction of beta-cell mass. Diabetes 61:2851-2861
13. Cai Q, Brissova M, Reinert RB et al (2012) Enhanced expression of VEGF-A in beta cells increases endothelial cell number but impairs islet morphogenesis and beta cell proliferation. Dev Biol 367:40-54
14. Milo-Landesman D, Surana M, Berkovich I et al (2001) Correction of hyperglycaemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant 10:645-650
15. Nir T, Melton DA, Dor Y (2007) Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 117:2553-2561
16. Dor Y, Camenisch TD, Itin A et al (2001) A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128:1531-1538
17. Mellitzer G, Bonné S, Luco RF et al (2006) IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J 25:1344-1352
18. McDonald DM, Choyke PL (2003) Imaging of angiogenesis: from microscope to clinic. Nat Med 9:713-725
19. Stangé G, Van De Casteele M, Heimberg H (2003) Purification of rat pancreatic beta-cells by fluorescence-activated cell sorting. Methods Mol Med 83:15-22
20. LeCouter J, Moritz DR, Li B et al (2003) Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science 299:890-893
21. Dong Z, Saikumar P, Weinberg JM, Venkatachalam MA (1997) Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases. Am J Pathol 151:1205-1213
22. Mellado-Gil J, Rosa TC, Demirci C et al (2011) Disruption of hepatocyte growth factor/c-Met signalling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes 60:525-536
23. Gannon G, Mandriota SJ, Cui L, Baetens D, Pepper MS, Christofori G (2002) Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during beta-cell carcinogenesis. Cancer Res 62:603-608
24. Rhodes C (2005) Type 2 diabetes - a matter of beta-cell life and death? Science 307:380-384
25. Del Bo R, Scarlato M, Ghezzi S et al (2006) VEGF gene variability and type 1 diabetes: evidence for a protective role. Immunogenetics 58:107-112
26. Christofori G, Naik P, Hanahan D (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9:1760-1770