Transgenic mouse technology in skin biology: Generation of complete or tissue-specific knockout mice

Journal of Investigative Dermatology

Volumn 134, Issue 1, 2014, Pages 1-5

  Scharfenberger, Lukas ^a   Hennerici, Tina ^b   Kirly, Gbor ^c   Kitzmüller, Sophie ^d   Vernooij, Marigje ^e   Zielinski, Julia G ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d UNIVERSITY OF SALZBURG   (Austria)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYTOKERATIN 14; GENOMIC DNA; NEOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; BLASTOCYST; DNA MODIFICATION; EMBRYONIC STEM CELL; GENE INACTIVATION; GENE MUTATION; GENE TARGETING; GENOTYPE; KNOCKOUT MOUSE; LOXP SITE; MICROENVIRONMENT; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN DISEASE; TRANSGENIC MOUSE; ANIMAL; DISEASE MODEL; GENETICS; MOUSE; PROCEDURES; TRANSGENE; METHODOLOGY; REVIEW;

ANIMALS; DISEASE MODELS, ANIMAL; GENE KNOCKOUT TECHNIQUES; MICE; MICE, KNOCKOUT; SKIN DISEASES; TRANSGENES;

EID: 84890902311     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.457     Document Type: Article

References (10)

1. Austin CP, Battey JF, Bradley A et al. (2004) The knockout mouse project. Nat Genet 36: 921-4
2. Clayton E, Doupe DP, Klein AM et al. (2007) A single type of progenitor cell maintains normal epidermis. Nature 446: 185-9
3. Gangoda L, Doerflinger M, Lee YY et al. (2012) Cre transgene results in global attenuation of the cAMP/PKA pathway. Cell Death Dis 3:e365
4. Gu H, Marth JD, Orban PC et al. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265: 103-6
5. Lewandoski M (2001) Conditional control of gene expression in the mouse. Nat Rev Genet 2: 743-55
6. Paigen K (2003) One hundred years of mouse genetics: an intellectual history. II. The molecular revolution (1981-2002). Genetics 163: 1227-35
7. Qiu W, Li X, Tang H et al. (2011) Conditional activin receptor type 1B (Acvr1b) knockout mice reveal hair loss abnormality. J Invest Dermatol 131: 1067-76
8. Seok J, Warren HS, Cuenca AG et al. (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 110: 3507-12
9. Vogel G (2007) Nobel Prizes. A knockout award in medicine. Science 318: 178-9
10. Wang Q, Ilves H, Chu P et al. (2007) Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model. J Invest Dermatol 127: 2577-84