Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: Results from the OMEGA study of the Dutch Breast Cancer Trialists' Group

Breast

Volumn 23, Issue 1, 2014, Pages 81-87

  Hamaker, M E ^a   Seynaeve, C ^b   Wymenga, A N M ^c   Van Tinteren, H ^d   Nortier, J W R ^e   Maartense, E ^f   De Graaf, H ^g   De Jongh, F E ^h   Braun, J J ⁱ   Los, M ^j   Schrama, J G ^k   Van Leeuwen Stok, A E ^l   De Groot, S M ^m   Smorenburg, C H ⁿ  

^a DEPARTMENT OF SURGERY   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c MEDISCH SPECTRUM TWENTE   (Netherlands)

^d ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f REINIER DE GRAAF HOSPITAL   (Netherlands)

^g MEDICAL CENTER LEEUWARDEN   (Netherlands)

^h IKAZIA HOSPITAL   (Netherlands)

ⁱ Vlietland Hospital   (Netherlands)

^j ST ANTONIUS HOSPITAL   (Netherlands)

^k Infection and Immunology   (Netherlands)

^l Dutch Breast Cancer Trialists' Group BOOG   (Netherlands)

^m Integraal Kankercentrum Amsterdam   (Netherlands)

ⁿ Location Alkmaar   (Netherlands)

more..

Author keywords

Geriatric assessment; Metastatic breast cancer; Palliative chemotherapy

Indexed keywords

CAPECITABINE; DOXORUBICIN;

AGED; ARTICLE; BODY MASS; BREAST METASTASIS; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CHARLSON COMORBIDITY INDEX; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DECISION MAKING; FATIGUE; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; GERIATRIC DEPRESSION SCALE; HAND FOOT SYNDROME; HUMAN; MAJOR CLINICAL STUDY; MINI MENTAL STATE EXAMINATION; MULTIPLE CYCLE TREATMENT; NUTRITIONAL STATUS; POLYPHARMACY; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMATITIS; VERY ELDERLY;

GERIATRIC ASSESSMENT; METASTATIC BREAST CANCER; PALLIATIVE CHEMOTHERAPY;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BODY MASS INDEX; BREAST NEOPLASMS; COGNITION DISORDERS; COMORBIDITY; DEOXYCYTIDINE; DEPRESSION; DOXORUBICIN; FATIGUE; FEMALE; FLUOROURACIL; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HAND-FOOT SYNDROME; HUMANS; MENTAL STATUS SCHEDULE; PALLIATIVE CARE; POLYETHYLENE GLYCOLS; POLYPHARMACY; RISK FACTORS; STOMATITIS; TREATMENT OUTCOME;

EID: 84890890361     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2013.11.004     Document Type: Article

References (47)

1. 3-2-2012. http://www.cbs.nl.
2. 2-3-2012. http://www.cijfersoverkanker.nl.
3. Hutchins L.F., Unger J.M., Crowley J.J., Coltman C.A., Albain K.S. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. NEngl J Med 1999, 341(27):2061-2067.
4. Peto R., Davies C., Godwin J., Gray R., Pan H.C., Clarke M., et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012, 379(9814):432-444.
5. Extermann M., Overcash J., Lyman G.H., Parr J., Balducci L. Comorbidity and functional status are independent in older cancer patients. JClin Oncol 1998, 16(4):1582-1587.
6. Louwman W.J., Vulto J.C., Verhoeven R.H., Nieuwenhuijzen G.A., Coebergh J.W., Voogd A.C. Clinical epidemiology of breast cancer in the elderly. Eur J Cancer 2007, 43(15):2242-2252.
7. Ferrucci L., Guralnik J.M., Studenski S., Fried L.P., Cutler G.B., Walston J.D. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. JAm Geriatr Soc 2004, 52(4):625-634.
8. Extermann M., Aapro M., Bernabei R., Cohen H.J., Droz J.P., Lichtman S., et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 2005, 55(3):241-252.
9. Slaets J.P. Vulnerability in the elderly: frailty. Med Clin North Am 2006, 90(4):593-601.
10. Extermann M., Meyer J., McGinnis M., Crocker T.T., Corcoran M.B., Yoder J., et al. Acomprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol 2004, 49(1):69-75.
11. Terret C., Albrand G., Droz J.P. Multidisciplinary geriatric assessment reveals unknown medical problems in elderly cancer patients. JClin Oncol 2004, 22(14S):8167.
12. Repetto L., Fratino L., Audisio R.A., Venturino A., Gianni W., Vercelli M., et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. JClin Oncol 2002, 20(2):494-502.
13. Trotti A., Colevas A.D., Setser A., Rusch V., Jaques D., Budach V., et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003, 13(3):176-181.
14. Aaronson N.K., Ahmedzai S., Bergman B., Bullinger M., Cull A., Duez N.J., et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. JNatl Cancer Inst 1993, 85(5):365-376.
15. Charlson M.E., Pompei P., Ales K.L., Mackenzie C.R. Anew method of classifying prognostic comorbidity in longitudinal studies: development and validation. JChronic Dis 1987, 40(5):373-383.
16. Lawton M.P., Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969, 9(3):179-186.
17. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res 1975, 12(3):189-198.
18. Sheikh J.I., Yesavage J.A., Brooks J.O., Friedman L., Gratzinger P., Hill R.D., et al. Proposed factor structure of the geriatric depression scale. Int Psychogeriatr 1991, 3(1):23-28.
19. De W.M., Honecker F., Wedding U., Waldenmaier D., Dorn J., Warm M., et al. Incorporation of a comprehensive geriatric assessment (CGA) into a randomized phase III trial for metastatic breast cancer (MBC): the PELICAN study. JClin Oncol 2010, 28(Suppl.15):1. Conference: 2010 Annual Meeting of the American Society of Clinical Oncology, ASCO Chicago, IL United States Conference Start: 20100604 Conference End: 20100608 Conference Publication: (var pagings).
20. De WM, Harbeck N, Scholz M, Lerbs W, Wedding U, Honecker F. Incorporation of a Comprehensive Geriatric Assessment (CGA) into a randomized phase III trial for metastatic breast cancer: The PELICAN Study. J Clin Oncol;27 (15 Suppl 1)(pp 9551):20. Conference: 2009 Annual Meeting of the American Society of Clinical Oncology, ASCO Orlando, FL United States Conference Start: 20090529 Conference End: 20090602 Conference Publication: (var pagings).
21. Sostelly A., Falandry C., Pejuade-Lauraine E., Freyer G., Tod M. Predicting chemotherapy induced hematotoxicity in elderly paients with metastatic breast cancer treated by pegylated liposomal doxorubicin. JClin Oncol 2011, e19740.
22. Lees J., Chan A. Polypharmacy in elderly patients with cancer: clinical implications and management. Lancet Oncol 2011 Dec, 12(13):1249-1257.
23. Beijnen J.H., Schellens J.H. Drug interactions in oncology. Lancet Oncol 2004, 5(8):489-496.
24. Blower P., de W.R., Goodin S., Aapro M. Drug-drug interactions in oncology: why are they important and can they be minimized?. Crit Rev Oncol Hematol 2005, 55(2):117-142.
25. Arnoldi E., Dieli M., Mangia M., Minetti B., Labianca R. Comprehensive geriatric assessment in elderly cancer patients: an experience in an outpatient population. Tumori 2007, 93(1):23-25.
26. Bamias A., Lainakis G., Kastritis E., Antoniou N., Alivizatos G., Koureas A., et al. Biweekly carboplatin/gemcitabine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: report of efficacy, quality of life and geriatric assessment. Oncology 2007, 73(5-6):290-297.
27. Basso U., Tonti S., Bassi C., Brunello A., Pasetto L.M., Scaglione D., et al. Management of Frail and Not-Frail elderly cancer patients in a hospital-based geriatric oncology program. Crit Rev Oncol Hematol 2008, 66(2):163-170.
28. Basso U., Falci C., Brunello A., Zafferri A., Fiduccia P., Sergi G., et al. Prognostic value of multidimensional geriatric assessment on survival of a prospective cohort of 880 elderly cancer patients. JClin Oncol 2011, S9065.
29. Poon D, Lee HH, Chan LL, Yap R, Koo WH. An exploratory analysis of comprehensive geriatric assessment results and overall survival in 233 consecutive elderly cancer patients. J Clin Oncol; 27 (15 Suppl 1)(pp 9504):20. Conference: 2009 Annual Meeting of the American Society of Clinical Oncology, ASCO Orlando, FL United States Conference Start: 20090529 Conference End: 20090602 Conference Publication: (var pagings).
30. Tucci A., Ferrari S., Bottelli C., Borlenghi E., Drera M., Rossi G. Acomprehensive geriatric assessment is more effective than clinical judgment to identify elderly diffuse large cell lymphoma patients who benefit from aggressive therapy. Cancer 2009, 115(19):4547-4553.
31. Brunello A., Monfardini S., Falci C., Zafferri V., Fiduccia P., Sergi G., et al. Prognostic role of comprehensive geriatric assessment (CGA): a prospective study of a cohort of 1038 elderly cancer patients. J.Geriatr. Oncol 2011, S36(2Suppl1).
32. Freyer G., Lortholary A., Delcambre C., Delozier T., Piot G., Genin F., et al. Unexpected toxicities in elderly patients treated with oral idarubicin in metastatic breast cancer: the GINECO experience. Clin Oncol (R Coll Radiol) 2004, 16(1):17-23.
33. Miller M.D., Paradis C.F., Houck P.R., Mazumdar S., Stack J.A., Rifai A.H., et al. Rating chronic medical illness burden in geropsychiatric practice and research: application of the cumulative illness rating scale. Psychiatry Res 1992, 41(3):237-248.
34. Maas H.A., Janssen-Heijnen M.L., Olde Rikkert M.G., Machteld Wymenga A.N. Comprehensive geriatric assessment and its clinical impact in oncology. Eur J Cancer 2007, 43(15):2161-2169.
35. Aaldriks A.A., Maartense E., le C.S., Giltay E.J., Verlaan H.A., van der Geest L.G., et al. Predictive value of geriatric assessment for patients older than 70 years, treated with chemotherapy. Crit Rev Oncol Hematol 2011, 79(2):205-212.
36. Van FF, Baitar A, De VM, Galdermans D, De DE, D'hooghe A etal. Prediction of chemotherapy toxicity by the groningen frailty index (GFI) and the comprehensive geriatric assessment (CGA) in elderly cancer patients (PTS): An interim analysis. Ann Oncol; 21 (pp viii185), 2010 Date of Publication: October 2010(var.pagings):October. Conference: 35th ESMO Congress Milan Italy Conference Start: 20101008 Conference End: 20101012 Conference Publication: (var pagings).
37. Extermann M., Boler I., Reich R.R., Lyman G.H., Brown R.H., Defelice J., et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer 2012 Jul 1, 118(13):3377-3386.
38. Hurria A., Togawa K., Mohile S.G., Owusu C., Klepin H.D., Gross C.P., et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. JClin Oncol 2011, 29(25):3457-3465.
39. Hamaker M.E., Jonker J.M., de Rooij S.E., Vos A.G., Smorenburg C.H., van Munster B.C. Frailty screening tools for predicting outcome of a comprehensive geriatric assessment in older cancer patients. Lancet Oncol 2012 Oct, 13(10):e437-e444.
40. Biesma B., Wymenga A.N., Vincent A., Dalesio O., Smit H.J., Stigt J.A., et al. Quality of life, geriatric assessment and survival in elderly patients with non-small-cell lung cancer treated with carboplatin-gemcitabine or carboplatin-paclitaxel: NVALT-3 a phase III study. Ann Oncol 2011, 22(7):1520-1527.
41. Honecker FU, Wedding U, Rettig K, Huschens S, Bokemeyer C. Use of the Comprehensive Geriatric Assessment (CGA) in elderly patients (pts) with solid tumors to predict mortality. J Clin Oncol;27 (15 Suppl 1)(pp 9549):20. Conference: 2009 Annual Meeting of the American Society of Clinical Oncology, ASCO Orlando, FL United States Conference Start: 20090529 Conference End: 20090602 Conference Publication: (var pagings).
42. Kanesvaran R., Li H., Koo K.N., Poon D. Analysis of prognostic factors of comprehensive geriatric assessment and development of a clinical scoring system in elderly asian patients with cancer. JClin Oncol 2011, 29(27):3620-3627.
43. Ramsdale E.E., Polite N., Bylow K.A., Kindler H.L., Dale W. Relationship between components of the comprehensive geriatric assessment, chemotherapy dose intensity, and overall survival in a colorectal cancer cohort age 65 and older. JClin Oncol 2011, S9000.
44. Kristjansson S.R., Jordhoy M.S., Nesbakken A., Skovlund E., Bakka A., Johannessen H.-O., et al. Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery?. JGeriatr Oncol 2010, 1(2):57-65. Date of Publication: October 2010(2):October.
45. Marinello R., Marenco D., Roglia D., Stasi M.F., Ferrando A., Ceccarelli M., et al. Predictors of treatment failures during chemotherapy: a prospective study on 110 older cancer patients. Arch Gerontol Geriatr 2009, 48(2):222-226.
46. Soubeyran P., Rainfray M., Mathoulin-Pelissier S., Blanc-Bisson C., Mertens C., Blanc J.F. Screening of elderly patients with cancer for early death risk. Results of a prospective multicentric study of 364 patients under chemotherapy. Crit Rev Oncol Hematol 2006, S23.
47. Wedding U., Rohrig B., Klippstein A., Pientka L., Hoffken K. Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients. JCancer Res Clin Oncol 2007, 133(12):945-950.