Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures

ACS Chemical Biology

Volumn 8, Issue 12, 2013, Pages 2794-2801

  Storz, Michael P ^a   Brengel, Christian ^a   Weidel, Elisabeth ^a,b   Hoffmann, Michael ^a   Hollemeyer, Klaus ^b   Steinbach, Anke ^a   Müller, Rolf ^a   Empting, Martin ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; HYDROXYL GROUP; PQSD INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOPHYSICS; CATALYSIS; CHEMICAL ANALYSIS; ENANTIOMER; ENTHALPY; ENTROPY; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CALORIMETRY; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MOLECULAR DOCKING SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RECOMBINANT PROTEINS; STEREOISOMERISM; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 84890852916     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400530d     Document Type: Article

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