Inhibitors of cyclin-dependent kinases. Synthesis of combinatorial libraries of 3-phenoxy-7-hydroxy-8-alkylaminomethylchromone derivatives and study on their anticancer activity

Biopolymers and Cell

Volumn 19, Issue 2, 2003, Pages 196-201

  Arkhipov, V V ^a   Prikhod'ko, A O ^a   Golub, A G ^a   Khilya, V P ^b   Yarmoluk, S M ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY AND GENETICS   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84890841166     PISSN: 02337657     EISSN: 19936842     Source Type: Journal    
DOI: 10.7124/bc.00064E     Document Type: Article

References (15)

1. Sielecki TM, Boylan JF, Benfield PA, Trainor GL. Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. (2000) J Med Chem. 2000;43(1):1-18.
2. Vasil'ev S.A., Luk'yanchikov M.S., Molchanov G.I., Turubarov V.D., Khilya V.P. Synthesis and biological properties of 3-phenoxchromones and 3-phenoxy-4-hydroxy-7-methoxycoumarin Pharmaceutical Chemistry Journal 1991; 25 (7), pp. 470-475
3. Ogorodnychuk A. S., Vassilyev S. A., Lekhan I. N., Khilya V. P., Shilyn V. V. Synthesis and properties of 3-fluorophenoxy-7-O-aminoacylchromones Russian Journal of Bioorganic Chemistry 1991; 17 (7):1005-1007
4. Gorbulenko N.V., Gaiduk O.V., Ogorodnychuk A.S., Khilya V.P., Shilin V.V. Amino-Acid derivatives of benzimidazole analogues of is oflavones. Doklady Akad Nauk Ukr SSR. 1991;(9):144-8
5. Graziani Y, Erikson E, Erikson RL. The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo (1983) Eur J Biochem. 1983;135(3):583-9.
6. Fischer PM, Lane DP. Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics. Curr Med Chem. 2000;7(12):1213-45
7. Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998;281(5376):533-8.
8. Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999;59(11):2566-9.
9. Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nat Struct Biol. 1997;4(10):796-801.
10. Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999;1(1):60-7
11. Nugiel DA, Etzkorn AM, Vidwans A, Benfield PA, Boisclair M, Burton CR, Cox S, Czerniak PM, Doleniak D, Seitz SP. Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors. J Med Chem. 2001;44(9):1334-6.
12. Walker DH. Small-molecule inhibitors of cyclin-dependent kinases: molecular tools and potential therapeutics. Curr Top Microbiol Immunol. 1998;227:149-65.
13. Senderowicz AM, Headlee D, Stinson SF, Lush RM, Kalil N, Villalba L, Hill K, Steinberg SM, Figg WD, Tompkins A, Arbuck SG, Sausville EA. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol. 1998;16(9):2986-99.
14. Arkhipov V. V., Smirnov M. N., Khilya V. P. Chemistry of modified flavonoids Chemistry of Heterocyclic Compounds 1997, 33(5) pp 515-519
15. Garazd M. M., Arkhipov V. V., Proskurka N. K., Khilya V. P. Chemistry of heteroanalogs of isoflavones. 23. Synthesis of aminoacyl derivatives of 3-phenoxychromone Chemistry of Heterocyclic Compounds Jue 1999, 35(6), pp 658-662