Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas

Pigment Cell and Melanoma Research

Volumn 27, Issue 1, 2014, Pages 90-102

  Gillard, Marc ^a,b   Cadieu, Edouard ^a,b   De Brito, Clotilde ^a,b   Abadie, Jérome ^c   Vergier, Béatrice ^d   Devauchelle, Patrick ^e   Degorce, Frédérique ^f   Dréano, Stephane ^a,b   Primot, Aline ^a,b   Dorso, Laetitia ^c   Lagadic, Marie ^g   Galibert, Francis ^a,b   Hédan, Benoit ^a,b   Galibert, Marie Dominique ^a,b   André, Catherine ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c LUNAM UNIVERSITÉ   (France)

^d HAUT LÉVÊQUE HOSPITAL   (France)

^e MICEN VET   (France)

^f Laboratoire d'Anatomie Pathologique Veterinaire du Sud Ouest   (France)

^g Laboratoire IDEXX Alfort   (France)

Author keywords

Dog model; Epidemiology; Genetics; His tology; Melanomas; Non UV pathways; Somatic mutations

Indexed keywords

B RAF KINASE; COMPLEMENTARY DNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREED DIFFERENCE; CANCER CLASSIFICATION; CANCER MODEL; CANCER RISK; CANCER TISSUE; CANINE MODEL; CARCINOGENESIS; COHORT ANALYSIS; CONTROLLED STUDY; CUTANEOUS MELANOMA; DNA SEQUENCE; DOG; EPIDEMIOLOGICAL DATA; FOLLOW UP; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LABRADOR RETRIEVER; MELANOMA; MOUTH TUMOR; NONHUMAN; ONCOGENE N RAS; ROTTWEILER; SOMATIC MUTATION; TERRIER;

ANIMALIA; CANIS FAMILIARIS;

DOG MODEL; EPIDEMIOLOGY; GENETICS; HIS-TOLOGY; MELANOMAS; NON-UV PATHWAYS; SOMATIC MUTATIONS;

ANIMALS; DISEASE MODELS, ANIMAL; DOG DISEASES; DOGS; HUMANS; MELANOMA; MOUTH NEOPLASMS; NEOPLASM PROTEINS; ULTRAVIOLET RAYS;

EID: 84890795445     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/pcmr.12170     Document Type: Article

References (55)

1. Adzhubei, I.A., Schmidt, S., Peshkin, L., Ramensky, V.E., Gerasimova, A., Bork, P., Kondrashov, A.S., and Sunyaev, S.R. (2010). A method and server for predicting damaging missense mutations. Nat. Methods 7, 248-249.
2. Bauer, J., Curtin, J.A., Pinkel, D., and Bastian, B.C. (2007). Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J. Invest. Dermatol. 127, 179-182.
3. Bergman, P.J. (2007). Canine oral melanoma. Clin. Tech. Small Anim. Pract. 22, 55-60.
4. Bradford, P.T. (2009). Skin cancer in skin of color. Dermatol. Nurs. 21, 170-177.
5. Broekaert, S.M., Roy, R., Okamoto, I. et al. (2010). Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res. 23, 763-770.
6. Cadieu, E., Neff, M.W., Quignon, P. et al. (2009). Coat variation in the domestic dog is governed by variants in three genes. Science 326, 150-153.
7. Cazenave, H., Maubec, E., Mohamdi, H., Grange, F., Bressac-de Paillerets, B., Demenais, F., and Avril, M.F. (2013). Anorectal and genital mucosal melanoma is associated with cutaneous melanoma in patients and in families. Br. J. Dermatol. 169, 594-599.
8. Delmas, V., Beermann, F., Martinozzi, S. et al. (2007). Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev. 21, 2923-2935.
9. Fecher, L.A., Amaravadi, R.K., and Flaherty, K.T. (2008). The MAPK pathway in melanoma. Curr. Opin. Oncol. 20, 183-189.
10. Flaherty, K.T. (2012). Throwing the kitchen sink at melanoma drug development. Pigment Cell Melanoma Res. 25, 543-544.
11. Fulci, G., Labuhn, M., Maier, D., Lachat, Y., Hausmann, O., Hegi, M.E., Janzer, R.C., Merlo, A., and Van Meir, E.G. (2000). p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene 19, 3816-3822.
12. Galibert, F., and Andre, C. (2008). The dog: a powerful model for studying genotype-phenotype relationships. Comp. Biochem. Physiol. Part D Genomics Proteomics 3, 67-77.
13. Goldschmidt, M.H., Dunstan, R.W., Stannard, A.A., Von Tscharner, C., Walder, E.J., and Yager, J.A. (1998). Epithelial and Melanocytic Tumors of the Skin of Domestic Animals. (Washington DC: Armed Forces Institute of Pathology, American Registry of Pathology, World Health Organization Collaborating Center for Comparative Oncology).
14. Grall, A., Guaguere, E., Planchais, S. et al. (2012). PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nat. Genet. 44, 140-147.
15. Harbour, J.W. (2012). The genetics of uveal melanoma: an emerging framework for targeted therapy. Pigment Cell Melanoma Res. 25, 171-181.
16. Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., and Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: a spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer 11, 201.
17. Heffel, D.F., and Thaller, S. (2005). Congenital melanosis: an update. J. Craniofac. Surg. 16, 940-944.
18. Karlsson, E.K., Baranowska, I., Wade, C.M. et al. (2007). Efficient mapping of mendelian traits in dogs through genome-wide association. Nat. Genet. 39, 1321-1328.
19. Khanna, C., and Gordon, I. (2009). Catching cancer by the tail: new perspectives on the use of kinase inhibitors. Clin. Cancer Res. 15, 3645-3647.
20. Kohno, T., Takahashi, M., Manda, R., and Yokota, J. (1998). Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers. Genes Chromosom. Cancer 22, 152-156.
21. Leboit, P.E., Burg, G., Weedon, D., and Sarasain, A. (2006). World Health Organization Classification of Tumours, Pathology and Genetics of Skin Tumours. (Lyon: IARC Press).
22. Lindblad-Toh, K., Wade, C.M., Mikkelsen, T.S. et al. (2005). Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438, 803-819.
23. Liu, W., Bennett, M., and Helm, T. (2011). Canine melanoma: a comparison with human pigmented epithelioid melanocytoma. Int. J. Dermatol. 50, 1542-1545.
24. Merveille, A.C., Davis, E.E., Becker-Heck, A. et al. (2011). CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nat. Genet. 43, 72-78.
25. Miteva, M., and Lazova, R. (2010). Spitz nevus and atypical spitzoid neoplasm. Semin. Cutan. Med. Surg. 29, 165-173.
26. Moreno-Bueno, G., Rodriguez-Perales, S., Sanchez-Estevez, C., Marcos, R., Hardisson, D., Cigudosa, J.C., and Palacios, J. (2004). Molecular alterations associated with cyclin D1 overexpression in endometrial cancer. Int. J. Cancer 110, 194-200.
27. Murakami, A., Mori, T., Sakai, H., Murakami, M., Yanai, T., Hoshino, Y., and Maruo, K. (2011). Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas. Vet. Comp. Oncol. 9, 219-224.
28. Ostrander, E.A. (2012). Franklin H. Epstein Lecture. Both ends of the leash-the human links to good dogs with bad genes. N. Engl. J. Med. 367, 636-646.
29. Papaspyrou, G., Garbe, C., Schadendorf, D., Werner, J.A., Hauschild, A., and Egberts, F. (2011). Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res. 21, 475-482.
30. Parker, H.G., Kukekova, A.V., Akey, D.T., Goldstein, O., Kirkness, E.F., Baysac, K.C., Mosher, D.S., Aguirre, G.D., Acland, G.M., and Ostrander, E.A. (2007). Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds. Genome Res. 17, 1562-1571.
31. Parker, H.G., Shearin, A.L., and Ostrander, E.A. (2010). Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu. Rev. Genet. 44, 309-336.
32. Pastor, M., Chalvet-Monfray, K., Marchal, T., Keck, G., Magnol, J.P., Fournel-Fleury, C., and Ponce, F. (2009). Genetic and environmental risk indicators in canine non-Hodgkin's lymphomas: breed associations and geographic distribution of 608 cases diagnosed throughout France over 1 year. J. Vet. Intern. Med. 23, 301-310.
33. Patrick, R.J., Fenske, N.A., and Messina, J.L. (2007). Primary mucosal melanoma. J. Am. Acad. Dermatol. 56, 828-834.
34. Phillips, J.C., Lembcke, L., and Chamberlin, T. (2010). A novel locus for canine osteosarcoma (OSA1) maps to CFA34, the canine orthologue of human 3q26. Genomics 96, 220-227.
35. Platz, A., Egyhazi, S., Ringborg, U., and Hansson, J. (2008). Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site. Mol. Oncol. 1, 395-405.
36. Ramos-Vara, J.A., Beissenherz, M.E., Miller, M.A., Johnson, G.C., Pace, L.W., Fard, A., and Kottler, S.J. (2000). Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Vet. Pathol. 37, 597-608.
37. Rees, J.L. (2008). Melanoma: what are the gaps in our knowledge. PLoS Med. 5, e122.
38. Rowell, J.L., Mccarthy, D.O., and Alvarez, C.E. (2011). Dog models of naturally occurring cancer. Trends Mol. Med. 17, 380-388.
39. Russak, J.E., and Rigel, D.S. (2012). Risk factors for the development of primary cutaneous melanoma. Dermatol. Clin. 30, 363-368.
40. Scolyer, R.A., Long, G.V., and Thompson, J.F. (2011). Evolving concepts in melanoma classification and their relevance to multidisciplinary melanoma patient care. Mol. Oncol. 5, 124-136.
41. Shearin, A.L., Hedan, B., Cadieu, E. et al. (2012). The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol. Biomarkers Prev. 21, 1019-1027.
42. Shelly, S., Chien, M.B., Yip, B., Kent, M.S., Theon, A.P., Mccallan, J.L., and London, C.A. (2005). Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas. Mamm. Genome 16, 211-217.
43. Shoo, B.A., and Kashani-Sabet, M. (2009). Melanoma arising in African-, Asian-, Latino- and Native-American populations. Semin. Cutan. Med. Surg. 28, 96-102.
44. Shull, A.Y., Latham-Schwark, A., Ramasamy, P., Leskoske, K., Oroian, D., Birtwistle, M.R., and Buckhaults, P.J. (2012). Novel somatic mutations to PI3K pathway genes in metastatic melanoma. PLoS ONE 7, e43369.
45. Smedley, R.C., Spangler, W.L., Esplin, D.G., Kitchell, B.E., Bergman, P.J., Ho, H.Y., Bergin, I.L., and Kiupel, M. (2011). Prognostic markers for canine melanocytic neoplasms: a comparative review of the literature and goals for future investigation. Vet. Pathol. 48, 54-72.
46. Smith, S.H., Goldschmidt, M.H., and Mcmanus, P.M. (2002). A comparative review of melanocytic neoplasms. Vet. Pathol. 39, 651-678.
47. Spangler, W.L., and Kass, P.H. (2006). The histologic and epidemiologic bases for prognostic considerations in canine melanocytic neoplasia. Vet. Pathol. 43, 136-149.
48. Taparowsky, E., Shimizu, K., Goldfarb, M., and Wigler, M. (1983). Structure and activation of the human N-ras gene. Cell 34, 581-586.
49. Thomas, R., Duke, S.E., Wang, H.J. et al. (2009). 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors. J. Neurooncol. 94, 333-349.
50. Turri-Zanoni, M., Medicina, D., Lombardi, D. et al. (2012). Sinonasal mucosal melanoma: molecular profile and therapeutic implications from a series of 32 cases. Head Neck 35, 1066-1077.
51. Vergier, B., Prochazkova-Carlotti, M., De La Fouchardiere, A. et al. (2011). Fluorescence in situ hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases. Mod. Pathol. 24, 613-623.
52. Whiteman, D.C., Pavan, W.J., and Bastian, B.C. (2011). The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res. 24, 879-897.
53. Wilcock, B.P., and Peiffer, R.L. Jr (1986). Morphology and behavior of primary ocular melanomas in 91 dogs. Vet. Pathol. 23, 418-424.
54. Zembowicz, A., and Phadke, P.A. (2011). Blue nevi and variants: an update. Arch. Pathol. Lab. Med. 135, 327-336.
55. Zembowicz, A., Carney, J.A., and Mihm, M.C. (2004). Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus. Am. J. Surg. Pathol. 28, 31-40.