Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer

Urologic Oncology: Seminars and Original Investigations

Volumn 32, Issue 1, 2014, Pages 25.e1-25.e12

  Sarwar, Martuza ^a   Sandberg, Sabina ^a   Abrahamsson, Per Anders ^b   Persson, Jenny L ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

AR; CAMP PKA pathways; CaP metastasis; Forskolin; Rolipram

Indexed keywords

ANDROGEN RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; MATRIX METALLOPROTEINASE; MESSENGER RNA; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV; PROSTATE SPECIFIC ANTIGEN; ROLIPRAM; AR PROTEIN, HUMAN; CYCLIC AMP; PDE4A PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL STRAIN LNCAP; CELL STRAIN PC3; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; METABOLISM; METASTASIS; PROSTATE TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; COLFORSIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; NEOPLASM METASTASIS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; ROLIPRAM; SIGNAL TRANSDUCTION;

EID: 84890794538     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2012.08.019     Document Type: Article

References (28)

1. Wegiel B., Evans S., Hellsten R., Otterbein L.E., Bjartell A., Persson J.L. Molecular pathways in the progression of hormone-independent and metastatic prostate cancer. Curr Cancer Drug Targets 2010, 10:392-401.
2. Nieto M., Finn S., Loda M., Hahn W.C. Prostate cancer: re-focusing on androgen receptor signaling. Int J Biochem Cell Biol 2007, 39:1562-1568.
3. Labrie F. Blockade of testicular and adrenal androgens in prostate cancer treatment. Nat Rev Urol 2011, 8:73-85.
4. Taplin M.E., Balk S.P. Androgen receptor: a key molecule in the progression of prostate cancer to hormone independence. J Cell Biochem 2004, 91:483-490.
5. Culig Z., Hobisch A., Cronauer M.V., et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994, 54:5474-5478.
6. Grossmann M.E., Huang H., Tindall D.J. Androgen receptor signaling in androgen-refractory prostate cancer. J Natl Cancer Inst 2001, 93:1687-1697.
7. Ueda T., Mawji N.R., Bruchovsky N., Sadar M.D. Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Biol Chem 2002, 277:38087-38094.
8. Merkle D., Hoffmann R. Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: cross-talk with the androgen receptor. Cell Signal 2011, 23:507-515.
9. Sadar M.D. Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase a signal transduction pathways. J Biol Chem 1999, 274:7777-7783.
10. Chin K.V., Yang W.L., Ravatn R., et al. Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling. Ann NY Acad Sci 2002, 968:49-64.
11. Taskén K., Skålhegg B.S., Solberg R., et al. Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. J Biol Chem 1993, 268:21276-21283.
12. Sands W.A., Palmer T.M. Regulating gene transcription in response to cyclic AMP elevation. Cell Signal 2008, 20:460-466.
13. Mayr B., Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001, 2:599-609.
14. Sakamoto K.M., Frank D.A. CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res 2009, 15:2583-2587.
15. Nazareth L.V., Weigel N.L. Activation of the human androgen receptor through a protein kinase a signaling pathway. J Biol Chem 1996, 271:19900-19907.
16. Desiniotis A., Schafer G., Klocker H., Eder I.E. Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A. Int J Cancer 2010, 126:775-789.
17. Chandran U.R., Ma C., Dhir R., et al. Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process. BMC Cancer 2007, 7:64.
18. Yu Y.P., Landsittel D., Jing L., et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol 2004, 22:2790-2799.
19. Simon R., Lam A., Li M.-C., Ngan M., Menenzes S., Zhao Y. Analysis of gene expression data using BRB-array tools. Cancer Inf 2007, 3:11-17.
20. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002, 2:161-174.
21. Wegiel B., Bjartell A., Tuomela J., et al. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. J Natl Cancer Inst 2008, 100:1022-1036.
22. Conti M., Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 2007, 76:481-511.
23. Cox M.E., Deeble P.D., Bissonette E.A., Parsons S.J. Activated 3',5'-cyclic amp-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line. J Biol Chem 2000, 275:13812-13818.
24. Cox M.E., Deeble P.D., Lakhani S., Parsons S.J. Acquisition of neuroendocrine characteristics by prostate tumor cells is reversible. Cancer Res 1999, 59:3821-3830.
25. Kashiwagi E., Shiota M., Yokomizo A., et al. Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer. The Prostate 2012, 72:741-751.
26. Chen C.D., Welsbie D.S., Tran C., et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004, 10:33-39.
27. Khor L.-Y., Bae K., Al-Saleem T., et al. Protein kinase A RI-α predicts for prostate cancer outcome: analysis of radiation therapy oncology group trial 86-10. Int J Radiat Oncol Biol Phys 2008, 71:1309-1315.
28. Pollack A., Bae K., Khor L.-Y., et al. The importance of protein kinase A in prostate cancer: relationship to patient outcome in radiation therapy oncology group trial 92-02. Clin Cancer Res 2009, 15:5478-5484.