Evaluation and mechanistic analysis of the cytotoxicity of the acyl glucuronide of nonsteroidal anti-inflammatory drugs

Drug Metabolism and Disposition

Volumn 42, Issue 1, 2014, Pages 1-8

  Miyashita, Taishi ^a   Kimura, Kento ^a   Fukami, Tatsuki ^a   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACYL GLUCURONIDE; CD14 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; DICLOFENAC; GLUCURONIDE; IBUPROFEN; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROBENECID; STRESS ACTIVATED PROTEIN KINASE 1; TOLMETIN; UNCLASSIFIED DRUG;

ARTICLE; CELL POPULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS, CD; CELL LINE, TUMOR; CHEMOKINE CCL2; HUMANS; INFLAMMATION; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKOCYTES, MONONUCLEAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84890784079     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.054478     Document Type: Article

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