Influence of histone deacetylase inhibitors and DNA-methyltransferase inhibitors on the NK cell-mediated lysis of pediatric B-lineage leukemia

Frontiers in Oncology

Volumn 3 APR, Issue , 2013, Pages

  Pfeiffer, Matthias Manuel ^a   Burow, Helen ^a   Schleicher, Sabine ^a   Handgretinger, Rupert ^a   Lang, Peter ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

DNMTi; HDACi; Immunotherapy; NK cells; Pediatric lymphoblastic leukemia

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; INTERLEUKIN 2; NECTIN 2; VALPROIC ACID; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL ACTIVITY; CELL EXPANSION; CELL STRAIN K 562; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EPIGENETICS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHATIC LEUKEMIA; NATURAL KILLER CELL; UPREGULATION;

EID: 84890730844     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00099     Document Type: Article

References (27)

1. Bhatla, T., Wang, J., Morrison, D. J., Raetz, E. A., Burke, M. J., Brown, P., et al. (2012). Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia. Blood 119, 5201-5210.
2. Chávez-Blanco, A., De la Cruz-Hernández, E., Domínguez, G. I., Rodríguez-Cortez, O., Alatorre, B., Pérez-Cárdenas, E., et al. (2011). Upregulation of NKG2D ligands and enhanced natural killer cell cytotoxicity by hydralazine and valproate. Int. J. Oncol. 39, 1491-1499.
3. Diermayr, S., Himmelreich, H., Durovic, B., Mathys-Schneeberger, A., Siegler, U., Langenkamp, U., et al. (2008). NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities. Blood 111, 1428-1436.
4. Einsiedel, H. G., Kawan, L., Eckert, C., Witt, O., Fichtner, I., Henze, G., et al. (2006). Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia. Leukemia 20, 1435-1436.
5. Fouladi, M., Park, J. R., Stewart, C. F., Gilbertson, R. J., Schaiquevich, P., Sun, J., et al. (2010). Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report. J. Clin. Oncol. 28, 3623-3629.
6. Handgretinger, R., Klingebiel, T., Lang, P., Schumm, M., Neu, S., Geiselhart, A., et al. (2001). Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children. Bone Marrow Transplant. 27, 777-783.
7. Kawagoe, R., Kawagoe, H., and Sano, K. (2002). Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and-independent apoptotic signaling pathways. Leuk. Res. 26, 495-502.
8. Kopp, L. M., Ray, A., Denman, C. J., Senyukov, V. S., Somanchi, S. S., Zhu, S., et al. (2013). Decitabine has a biphasic effect on natural killer cell viability, phenotype and function under proliferative conditions. Mol. Immunol. 54, 296-301.
9. Lang, P., Handgretinger, R., Niethammer, D., Schlegel, P. G., Schumm, M., Greil, J., et al. (2003). Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood 101, 1630-1636.
10. Lang, P., Pfeiffer, M., Teltschik, H. M., Schlegel, P., Feuchtinger, T., Ebinger, M., et al. (2011). Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors. Best Pract. Res. Clin. Haematol. 24, 403-411.
11. Lanier, L. L. (2005). NK cell recognition. Annu. Rev. Immunol. 23, 225-274.
12. Leclerc, G. J., Mou, C., Leclerc, G. M., Mian, A. M., and Barredo, J. C. (2010). Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of longchain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia 24, 552-562.
13. Leung, W., Iyengar, R., Turner, V., Lang, P., Bader, P., Conn, P., et al. (2004). Determinants of antileukemia effects of allogeneic NK cells. J. Immunol. 172, 644-650.
14. López-Soto, A., Folgueras, A. R., Seto, E., and Gonzalez, S. (2009). HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer. Oncogene 28, 2370-2382.
15. Lowdell, M. W., Craston, R., Samuel, D., Wood, M. E., O'Neill, E., Saha, V., et al. (2002). Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells. Br. J. Haematol. 117, 821-827.
16. Marks, D. I., Khattry, N., Cummins, M., Goulden, N., Green, A., Harvey, J., et al. (2006). Haploidentical stem cell transplantation for children with acute leukaemia. Br. J. Haematol. 134, 196-201.
17. Moretta, A., Bottino, C., Vitale, M., Pende, D., Cantoni, C., Mingari, M. C., et al. (2001). Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197-223.
18. Ogbomo, H., Michaelis, M., Kreuter, J., Doerr, H. W., and Cinatl, J. Jr. (2007). Histone deacetylase inhibitors suppress natural killer cell cytolytic activity. FEBS Lett. 581, 1317-1322.
19. Pende, D., Spaggiari, G. M., Marcenaro, S., Martini, S., Rivera, P., Capobianco, A., et al. (2005). Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 105, 2066-2073.
20. Pfeiffer, M., Schumm, M., Feuchtinger, T., Dietz, K., Handgretinger, R., and Lang, P. (2007). Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia. Br. J. Haematol. 138, 97-100.
21. Pfeiffer, M. M., Feuchtinger, T., Teltschik, H. M., Schumm, M., Müller, I., Handgretinger, R., et al. (2010). Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T-and B-cell depleted grafts in children. Haematologica 95, 1381-1388.
22. Rohner, A., Langenkamp, U., Siegler, U., Kalberer, C. P., and Wodnar-Filipowicz, A. (2007). Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. Leuk. Res. 31, 1393-1402.
23. Rossi, L. E., Avila, D. E., Spallanzani, R. G., Ziblat, A., Fuertes, M. B., Lapyckyj, L., et al. (2012). Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J. Leukoc. Biol. 91, 321-331.
24. Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., et al. (2002). Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097-2100.
25. Sakajiri, S., Kumagai, T., Kawamata, N., Saitoh, T., Said, J. W., and Koeffler, H. P. (2005). Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp. Hematol. 33, 53-61.
26. Schmiedel, B. J., Arélin, V., Gruenebach, F., Krusch, M., Schmidt, S. M., and Salih, H. R. (2011). Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation. Int. J. Cancer 128, 2911-2922.
27. Yang, H., Hoshino, K., Sanchez-Gonzalez, B., Kantarjian, H., and Garcia-Manero, G. (2005). Antileukemia activity of the combination of 5-aza-2-deoxycytidine with valproic acid. Leuk. Res. 29, 739-748.