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Volumn 3 MAR, Issue , 2013, Pages

Role of EZH2 in epithelial ovarian cancer: From biological insights to therapeutic target

Author keywords

Epigenetic therapeutics; Epithelial ovarian cancer; EZH2; EZH2 inhibitors; PRC2

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 1; EPZ 005687; GSK 126; HISTONE METHYLTRANSFERASE; METHYLTRANSFERASE; POLYCOMB REPRESSIVE COMPLEX 2; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

EID: 84890584944     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00047     Document Type: Short Survey
Times cited : (21)

References (52)
  • 1
    • 35148867907 scopus 로고    scopus 로고
    • UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    • Agger, K., Cloos, P. A., Christensen, J., Pasini, D., Rose, S., Rappsilber, J., et al. (2007). UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449, 731-734.
    • (2007) Nature , vol.449 , pp. 731-734
    • Agger, K.1    Cloos, P.A.2    Christensen, J.3    Pasini, D.4    Rose, S.5    Rappsilber, J.6
  • 2
    • 4143111260 scopus 로고    scopus 로고
    • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
    • Altomare, D. A., Wang, H. Q., Skele, K. L., De Rienzo, A., Klein-Szanto, A. J., Godwin, A. K., et al. (2004). AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 23, 5853-5857.
    • (2004) Oncogene , vol.23 , pp. 5853-5857
    • Altomare, D.A.1    Wang, H.Q.2    Skele, K.L.3    De Rienzo, A.4    Klein-Szanto, A.J.5    Godwin, A.K.6
  • 3
    • 0003964363 scopus 로고    scopus 로고
    • American Cancer Society. Atlanta: American Cancer Society.
    • American Cancer Society. (2012). Cancer Facts & Figures 2012. Atlanta: American Cancer Society.
    • (2012) Cancer Facts & Figures 2012
  • 6
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., and Helin, K. (2006). Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20, 1123-1136.
    • (2006) Genes Dev. , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 8
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • Cao, R., and Zhang, Y. (2004). SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57-67.
    • (2004) Mol. Cell , vol.15 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 9
    • 26844520965 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    • Cha, T. L., Zhou, B. P., Xia, W., Wu, Y., Yang, C. C., Chen, C. T., et al. (2005). Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310, 306-310.
    • (2005) Science , vol.310 , pp. 306-310
    • Cha, T.L.1    Zhou, B.P.2    Xia, W.3    Wu, Y.4    Yang, C.C.5    Chen, C.T.6
  • 10
    • 78149285100 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2
    • Chen, S., Bohrer, L. R., Rai, A. N., Pan, Y., Gan, L., Zhou, X., et al. (2010). Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. Nat. Cell Biol. 12, 1108-1114.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1108-1114
    • Chen, S.1    Bohrer, L.R.2    Rai, A.N.3    Pan, Y.4    Gan, L.5    Zhou, X.6
  • 11
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: from mechanism to therapy
    • Dawson, M. A., and Kouzarides, T. (2012). Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27.
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 12
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • Gui, Y., Guo, G., Huang, Y., Hu, X., Tang, A., Gao, S., et al. (2011). Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat. Genet. 43, 875-878.
    • (2011) Nat. Genet. , vol.43 , pp. 875-878
    • Gui, Y.1    Guo, G.2    Huang, Y.3    Hu, X.4    Tang, A.5    Gao, S.6
  • 14
    • 78049307003 scopus 로고    scopus 로고
    • Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo
    • Hu, S., Yu, L., Li, Z., Shen, Y., Wang, J., Cai, J., et al. (2010). Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo. Cancer Biol. Ther. 10, 788-795.
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 788-795
    • Hu, S.1    Yu, L.2    Li, Z.3    Shen, Y.4    Wang, J.5    Cai, J.6
  • 15
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch, R., and Young, R. (2008). Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132, 567-582.
    • (2008) Cell , vol.132 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 16
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
    • Jankowska, A. M., Makishima, H., Tiu, R. V., Szpurka, H., Huang, Y., Traina, F., et al. (2011). Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 118, 3932-3941.
    • (2011) Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3    Szpurka, H.4    Huang, Y.5    Traina, F.6
  • 17
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P. A., and Baylin, S. B. (2007). The epigenomics of cancer. Cell 128, 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 18
    • 23344450547 scopus 로고    scopus 로고
    • Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes
    • Ketel, C. S., Andersen, E. F., Vargas, M. L., Suh, J., Strome, S., and Simon, J. A. (2005). Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes. Mol. Cell. Biol. 25, 6857-6868.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6857-6868
    • Ketel, C.S.1    Andersen, E.F.2    Vargas, M.L.3    Suh, J.4    Strome, S.5    Simon, J.A.6
  • 19
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., et al. (2003). EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 100, 11606-11611.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 21
    • 84867251637 scopus 로고    scopus 로고
    • Ovarian cancer is an imported disease: fact or fiction?
    • Kuhn, E., Kurman, R. J., and Shih, I. M. (2012). Ovarian cancer is an imported disease: fact or fiction? Curr. Obstet. Gynecol. Rep. 1, 1-9.
    • (2012) Curr. Obstet. Gynecol. Rep. , vol.1 , pp. 1-9
    • Kuhn, E.1    Kurman, R.J.2    Shih, I.M.3
  • 22
    • 77649219639 scopus 로고    scopus 로고
    • The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory
    • Kurman, R. J., and Shih, I. M. (2010). The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am. J. Surg. Pathol. 34, 433-443.
    • (2010) Am. J. Surg. Pathol. , vol.34 , pp. 433-443
    • Kurman, R.J.1    Shih, I.M.2
  • 23
    • 77953120646 scopus 로고    scopus 로고
    • Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
    • Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jorgensen, H. F., et al. (2010). Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat. Cell Biol. 12, 618-624.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 618-624
    • Landeira, D.1    Sauer, S.2    Poot, R.3    Dvorkina, M.4    Mazzarella, L.5    Jorgensen, H.F.6
  • 24
    • 84870308969 scopus 로고    scopus 로고
    • EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex
    • Lee, J. M., Lee, J. S., Kim, H., Kim, K., Park, H., Kim, J. Y., et al. (2012). EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol. Cell 48, 572-586.
    • (2012) Mol. Cell , vol.48 , pp. 572-586
    • Lee, J.M.1    Lee, J.S.2    Kim, H.3    Kim, K.4    Park, H.5    Kim, J.Y.6
  • 25
    • 55949089955 scopus 로고    scopus 로고
    • New insights into the pathogenesis of serous ovarian cancer and its clinical impact
    • Levanon, K., Crum, C., and Drapkin, R. (2008). New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J. Clin. Oncol. 26, 5284-5293.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5284-5293
    • Levanon, K.1    Crum, C.2    Drapkin, R.3
  • 26
    • 84859462010 scopus 로고    scopus 로고
    • ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches
    • Li, H., Bitler, B. G., Vathipadiekal, V., Maradeo, M. E., Slifker, M., Creasy, C. L., et al. (2012a). ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. Cancer Prev. Res. (Phila.) 5, 484-491.
    • (2012) Cancer Prev. Res. (Phila.) , vol.5 , pp. 484-491
    • Li, H.1    Bitler, B.G.2    Vathipadiekal, V.3    Maradeo, M.E.4    Slifker, M.5    Creasy, C.L.6
  • 27
    • 84869225502 scopus 로고    scopus 로고
    • SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK
    • Li, H., Cai, Q., Wu, H., Vathipadiekal, V., Dobbin, Z. C., Li, T., et al. (2012b). SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. Mol. Cancer Res. 10, 1462-1472.
    • (2012) Mol. Cancer Res. , vol.10 , pp. 1462-1472
    • Li, H.1    Cai, Q.2    Wu, H.3    Vathipadiekal, V.4    Dobbin, Z.C.5    Li, T.6
  • 28
    • 78650493658 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells
    • Li, H., Cai, Q., Godwin, A. K., and Zhang, R. (2010). Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol. Cancer Res. 8, 1610-1618.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1610-1618
    • Li, H.1    Cai, Q.2    Godwin, A.K.3    Zhang, R.4
  • 30
    • 84866597616 scopus 로고    scopus 로고
    • A687V EZH2 is a gain-of-function mutation found in lymphoma patients
    • Majer, C. R., Jin, L., Scott, M. P., Knutson, S. K., Kuntz, K. W., Keilhack, H., et al. (2012). A687V EZH2 is a gain-of-function mutation found in lymphoma patients. FEBS Lett. 586, 3448-3451.
    • (2012) FEBS Lett. , vol.586 , pp. 3448-3451
    • Majer, C.R.1    Jin, L.2    Scott, M.P.3    Knutson, S.K.4    Kuntz, K.W.5    Keilhack, H.6
  • 31
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    • McCabe, M. T., Graves, A. P., Ganji, G., Diaz, E., Halsey, W. S., Jiang, Y., et al. (2012a). Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl. Acad. Sci. U.S.A. 109, 2989-2994.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 2989-2994
    • McCabe, M.T.1    Graves, A.P.2    Ganji, G.3    Diaz, E.4    Halsey, W.S.5    Jiang, Y.6
  • 32
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe, M. T., Ott, H. M., Ganji, G., Korenchuk, S., Thompson, C., Van Aller, G. S., et al. (2012b). EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 492, 108-112.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3    Korenchuk, S.4    Thompson, C.5    Van Aller, G.S.6
  • 33
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda, T. B., Cortez, C. C., Yoo, C. B., Liang, G., Abe, M., Kelly, T. K., et al. (2009). DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther. 8, 1579-1588.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3    Liang, G.4    Abe, M.5    Kelly, T.K.6
  • 34
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin, R. D., Johnson, N. A., Severson, T. M., Mungall, A. J., An, J., Goya, R., et al. (2010). Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42, 181-185.
    • (2010) Nat. Genet. , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3    Mungall, A.J.4    An, J.5    Goya, R.6
  • 35
    • 68149152279 scopus 로고    scopus 로고
    • The role of HRK gene in human cancer
    • Nakamura, M., Shimada, K., and Konishi, N. (2008). The role of HRK gene in human cancer. Oncogene 27(Suppl. 1), S105-S113.
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Nakamura, M.1    Shimada, K.2    Konishi, N.3
  • 36
    • 77957357566 scopus 로고    scopus 로고
    • TNF/p38alpha/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration
    • Palacios, D., Mozzetta, C., Consalvi, S., Caretti, G., Saccone, V., Proserpio, V., et al. (2010). TNF/p38alpha/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell 7, 455-469.
    • (2010) Cell Stem Cell , vol.7 , pp. 455-469
    • Palacios, D.1    Mozzetta, C.2    Consalvi, S.3    Caretti, G.4    Saccone, V.5    Proserpio, V.6
  • 38
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi, W., Chan, H., Teng, L., Li, L., Chuai, S., Zhang, R., et al. (2012). Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc. Natl. Acad. Sci. U.S.A. 109, 21360-21365.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3    Li, L.4    Chuai, S.5    Zhang, R.6
  • 39
    • 77956277833 scopus 로고    scopus 로고
    • EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients
    • Rao, Z. Y., Cai, M. Y., Yang, G. F., He, L. R., Mai, S. J., Hua, W. F., et al. (2010). EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients. Carcinogenesis 31, 1576-1583.
    • (2010) Carcinogenesis , vol.31 , pp. 1576-1583
    • Rao, Z.Y.1    Cai, M.Y.2    Yang, G.F.3    He, L.R.4    Mai, S.J.5    Hua, W.F.6
  • 40
    • 79951825513 scopus 로고    scopus 로고
    • Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2
    • Rizzo, S., Hersey, J. M., Mellor, P., Dai, W., Santos-Silva, A., Liber, D., et al. (2011). Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2. Mol. Cancer Ther. 10, 325-335.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 325-335
    • Rizzo, S.1    Hersey, J.M.2    Mellor, P.3    Dai, W.4    Santos-Silva, A.5    Liber, D.6
  • 41
    • 83355173202 scopus 로고    scopus 로고
    • EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas
    • doi:10.1371/journal.pone.0028585
    • Ryan, R. J., Nitta, M., Borger, D., Zukerberg, L. R., Ferry, J. A., Harris, N. L., et al. (2011). EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE 6:e28585. doi:10.1371/journal.pone.0028585
    • (2011) PLoS ONE , vol.6
    • Ryan, R.J.1    Nitta, M.2    Borger, D.3    Zukerberg, L.R.4    Ferry, J.A.5    Harris, N.L.6
  • 42
    • 33845799903 scopus 로고    scopus 로고
    • Polycomb silencing mechanisms and the management of genomic programmes
    • Schwartz, Y. B., and Pirrotta, V. (2007). Polycomb silencing mechanisms and the management of genomic programmes. Nat. Rev. Genet. 8, 9-22.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 9-22
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 43
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer, C. J., Scott, M. P., Kuntz, K. W., Knutson, S. K., Pollock, R. M., Richon, V. M., et al. (2010). Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl. Acad. Sci. U.S.A. 107, 20980-20985.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3    Knutson, S.K.4    Pollock, R.M.5    Richon, V.M.6
  • 44
    • 21044451441 scopus 로고    scopus 로고
    • Polycomb group protein ezh2 controls actin polymerization and cell signaling
    • Su, I. H., Dobenecker, M. W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., et al. (2005). Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 121, 425-436.
    • (2005) Cell , vol.121 , pp. 425-436
    • Su, I.H.1    Dobenecker, M.W.2    Dickinson, E.3    Oser, M.4    Basavaraj, A.5    Marqueron, R.6
  • 45
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P. L., et al. (2007). Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21, 1050-1063.
    • (2007) Genes Dev. , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6
  • 46
    • 33845417885 scopus 로고    scopus 로고
    • The cancer epigenome-components and functional correlates
    • Ting, A. H., McGarvey, K. M., and Baylin, S. B. (2006). The cancer epigenome-components and functional correlates. Genes Dev. 20, 3215-3231.
    • (2006) Genes Dev. , vol.20 , pp. 3215-3231
    • Ting, A.H.1    McGarvey, K.M.2    Baylin, S.B.3
  • 47
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai, M. C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., et al. (2010). Long noncoding RNA as modular scaffold of histone modification complexes. Science 329, 689-693.
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1    Manor, O.2    Wan, Y.3    Mosammaparast, N.4    Wang, J.K.5    Lan, F.6
  • 48
    • 0032751323 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
    • Van der Vlag, J., and Otte, A. P. (1999). Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat. Genet. 23, 474-478.
    • (1999) Nat. Genet. , vol.23 , pp. 474-478
    • Van der Vlag, J.1    Otte, A.P.2
  • 50
    • 50249175130 scopus 로고    scopus 로고
    • Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
    • Wei, Y., Xia, W., Zhang, Z., Liu, J., Wang, H., Adsay, N. V., et al. (2008). Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol. Carcinog. 47, 701-706.
    • (2008) Mol. Carcinog. , vol.47 , pp. 701-706
    • Wei, Y.1    Xia, W.2    Zhang, Z.3    Liu, J.4    Wang, H.5    Adsay, N.V.6
  • 51
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is polycomb-independent
    • Xu, K., Wu, Z. J., Groner, A. C., and He, H. H. (2012). EZH2 oncogenic activity in castration-resistant prostate cancer cells is polycomb-independent. Science 338, 1465-1469.
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4
  • 52
    • 55349109963 scopus 로고    scopus 로고
    • Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    • Zhao, J., Sun, B. K., Erwin, J. A., Song, J. J., and Lee, J. T. (2008). Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322, 750-756.
    • (2008) Science , vol.322 , pp. 750-756
    • Zhao, J.1    Sun, B.K.2    Erwin, J.A.3    Song, J.J.4    Lee, J.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.