Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition

Neuropsychopharmacology

Volumn 39, Issue 2, 2014, Pages 464-476

  King, Madeleine V ^a   Kurian, Nisha ^a,e   Qin, Si ^b,c   Papadopoulou, Nektaria ^a,f   Westerink, Ben Hc ^b,c   Cremers, Thomas I ^b,c   Epping Jordan, Mark P ^d   Le Poul, Emmanuel ^d   Ray, David E ^a   Fone, Kevin Cf ^a   Kendall, David A ^a   Marsden, Charles A ^a   Sharp, Tyson V ^a,g  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c CHARLES RIVER LABORATORIES   (United States)

^d ADDEX PHARMACEUTICALS   (Switzerland)

^e ASTRAZENECA R AND D   (Sweden)

^f Precos Ltd In vivo services   (United Kingdom)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

glutamate; hippocampus; learning; memory; shRNA; VGLUT1

Indexed keywords

4 AMINOBUTYRIC ACID; CD11B ANTIGEN; GLUTAMIC ACID; SHORT HAIRPIN RNA; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATIVE MEMORY; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FEAR; GENE SILENCING; HIPPOCAMPUS; IN VITRO STUDY; LATENT PERIOD; LOCOMOTION; MALE; MAZE TEST; MEMORY DISORDER; MOTOR COORDINATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA VECTOR; ROTAROD TEST; SIGNAL TRANSDUCTION; SPATIAL LEARNING; VISUAL MEMORY;

ANIMALS; CELL LINE; COGNITION DISORDERS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HIPPOCAMPUS; LENTIVIRUS; MALE; MICE; MICE, INBRED C57BL; RNA, SMALL INTERFERING; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 84890569069     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.220     Document Type: Article

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