Late-onset neonatal sepsis, risk factors and interventions: An analysis of recurrent outbreaks of Serratia marcescens, 2006-2011

Journal of Hospital Infection

Volumn 86, Issue 1, 2014, Pages 57-63

  Samuelsson, A ^a,b   Isaksson, B ^a,b   Hanberger, H ^a,b   Olhager, E ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Department of Clinical Immunology and Transfusion Medicine   (Sweden)

Author keywords

Late onset sepsis; Neonatal; Outbreak; Serratia marcescens

Indexed keywords

GENTAMICIN; MEROPENEM; PENICILLIN G; TOBRAMYCIN;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COLONIZATION; CENTRAL VENOUS CATHETER; CLINICAL ARTICLE; COMPLIANCE (PHYSICAL); CONTROLLED STUDY; ENVIRONMENTAL SANITATION; EPIDEMIC; EQUIPMENT MAINTENANCE; FEMALE; GESTATIONAL AGE; GRAM NEGATIVE SEPSIS; HOSPITAL POLICY; HUMAN; HYGIENE; INTERVENTION STUDY; LOW BIRTH WEIGHT; MALE; MEDICAL RECORD REVIEW; NEWBORN; NEWBORN SEPSIS; OBSERVATIONAL STUDY; PRACTICE GUIDELINE; RECURRENT DISEASE; RISK FACTOR; SERRATIA MARCESCENS; VENTILATOR;

LATE-ONSET SEPSIS; NEONATAL; OUTBREAK; SERRATIA MARCESCENS;

ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CROSS INFECTION; DISEASE OUTBREAKS; DRUG PRESCRIPTIONS; HUMANS; INFANT; INFANT, NEWBORN; INFECTION CONTROL; RECURRENCE; RETROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SERRATIA INFECTIONS; SERRATIA MARCESCENS;

EID: 84890557406     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2013.09.017     Document Type: Article

References (21)

1. Vergnano S., Sharland M., Kazembe P., Mwansambo C., Heath P.T. Neonatal sepsis: an international perspective. Arch Dis Childhood Fetal Neonat Ed 2005, 90:220-224.
2. Westerbeek E.A., van den Berg A., Lafeber H.N., Knol J., Fetter W.P., van Elburg R.M. The intestinal bacterial colonisation in preterm infants: a review of the literature. Clin Nutr 2006, 25:361-368.
3. Fryklund B., Tullus K., Berglund B., Burman L.G. Importance of the environmental and the fecal flora of infants, nursing staff and parents as sources of Gram-negative bacteria colonizing newborns in 3 neonatal wards. Infection 1992, 20:253-257.
4. Milisavljevic V., Wu F., Cimmotti J., et al. Genetic relatedness of Staphylococcus epidermidis from infected infants and staff in the neonatal intensive care unit. Am J Infect Control 2005, 33:341-347.
5. Kaoutar B., Joly C., L'Hériteau F., et al. Nosocomial infections and hospital mortality: a multicentre epidemiological study. JHosp Infect 2004, 58:268-275.
6. Stoll B.J., Hansen N., Fanaroff A.A., et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002, 110:285-291.
7. Norman M., Blennow M., Vineta F., et al. Incidence of and risk factors for neonatal morbidity after active perinatal care: extremely preterm infants study in Sweden (Express). Acta Paediatr 2010, 99:978-992.
8. Borghesi A., Stronati M. Strategies for the prevention of hospital-acquired infections in the neonatal intensive care unit. JHosp Infect 2008, 68:293-300.
9. Pratt R.J., Pellowe C., Loveday H.P., et al. The epic project: developing national evidence-based guidelines for preventing healthcare associated infections. Phase I: Guidelines for preventing hospital-acquired infections. Department of Health (England). JHosp Infect 2001, 47(Suppl.):S3-S82.
10. Manual of clinical microbiology 2007, American Society of Microbiology, Washington, DC. 9th ed. P.R. Murray, E.J. Baron, J.H. Jorgensen, M.A. Pfaller, M.L. Landry (Eds.).
11. Tenover F.C., Arbeit R.D., Goering R.V., et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel-electrophoresis - criteria for bacterial strain typing. JClin Microbiol 1995, 33:2233-2239.
12. Benitz W.E., Han M.Y., Madan A., Ramachandra P. Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics 1998, 102:E41.
13. Ng P.C. Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed 2004, 89:F229-F235.
14. Gastmeier P., Geffers C., Schwab F., Fitzner J., Obladen M., Rãden H. Development of a surveillance system for nosocomial infections: the component for neonatal intensive care units in Germany. JHosp Infect 2004, 57:126-131.
15. Jiang J.H., Chiu N.C., Huang F.Y., et al. Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. JMicrobiol Immunol Infect 2004, 37:301-306.
16. Holmes A., Doré C.J., Saraswatula A., et al. Risk factors and recommendations for rate stratification for surveillance of neonatal healthcare-associated bloodstream infection. JHosp Infect 2008, 68:66-72.
17. Adamson V., Mitt P., Pisarev H., et al. Prolonged outbreak of Serratia marcescens in Tartu University Hospital: a case-control study. BMC Infect Dis 2012, 12:281.
18. Finnstrom O., Isaksson B., Haeggman S., Burman L.G. Control of an outbreak of a highly beta-lactam-resistant Enterobacter cloacae strain in a neonatal special care unit. Acta Paediatr 1998, 87:1070-1074.
19. Pittet D., Allegranzi B., Sax H., et al. Evidence-based model for hand transmission during patient care and the role of improved practices. Lancet Infect Dis 2006, 6:641-652.
20. Voelz A., Muller A., Gillen J., et al. Outbreaks of Serratia marcescens in neonatal and pediatric intensive care units: clinical aspects, risk factors and management. Int J Hyg Environ Health 2010, 213:79-87.
21. Mernelius S., Svensson P.O., Rensfeldt G., et al. Compliance with hygiene guidelines: the effect of a multimodal hygiene intervention and validation of direct observations. Am J Infect Control 2013, 41:e45-e48.