Outbreaks of Serratia marcescens in neonatal and pediatric intensive care units: Clinical aspects, risk factors and management

International Journal of Hygiene and Environmental Health

Volumn 213, Issue 2, 2010, Pages 79-87

  Voelz, Alexander ^a   Müller, Andreas ^a   Gillen, Julia ^a   Le, Celine ^a   Dresbach, Till ^a   Engelhart, Steffen ^a   Exner, Martin ^a   Bates, Christine J ^b   Simon, Arne ^a  

^a UNIVERSITY OF BONN   (Germany)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Contact isolation genotyping; Neonatal intensive care unit; Nosocomial infection; Pediatric intensive care unit; Serratia marcescens

Indexed keywords

ANTIINFECTIVE AGENT;

ARTICLE; CROSS INFECTION; DISEASE TRANSMISSION; EPIDEMIC; GENETICS; GENOTYPE; HUMAN; INFECTION CONTROL; MICROBIOLOGICAL EXAMINATION; NEWBORN INTENSIVE CARE; RISK FACTOR; SERRATIA INFECTION; SERRATIA MARCESCENS; STATISTICS;

ANTI-BACTERIAL AGENTS; CROSS INFECTION; DISEASE OUTBREAKS; GENOTYPE; HUMANS; INFECTION CONTROL; INTENSIVE CARE UNITS, NEONATAL; MICROBIAL SENSITIVITY TESTS; RISK FACTORS; SERRATIA INFECTIONS; SERRATIA MARCESCENS;

SERRATIA MARCESCENS;

EID: 77649232900     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2009.09.003     Document Type: Article

References (69)

1. Al Jarousha A.M., El Qouqa I.A., El Jadba A.H., and Al Afifi A.S. An outbreak of Serratia marcescens septicaemia in neonatal intensive care unit in Gaza City, Palestine. J. Hosp. Infect. 70 (2008) 119-126
2. American Academy of Pediatrics and Committee on Infectious Diseases. The use of systemic fluoroquinolones. Pediatrics 118 (2006) 1287-1292
3. Andersen B.M., Lindemann R., Bergh K., Nesheim B.I., Syversen G., Solheim N., and Laugerud F. Spread of methicillin-resistant Staphylococcus aureus in a neonatal intensive unit associated with understaffing, overcrowding and mixing of patients. J. Hosp. Infect. 50 (2002) 18-24
4. Anderson B., Nicholas S., Sprague B., Campos J., Short B., and Singh N. Molecular and descriptive epidemiology of multidrug-resistant Enterobacteriaceae in hospitalized infants *. Infect. Control Hosp. Epidemiol. 29 (2008) 250-255
5. Archibald L.K., Corl A., Shah B., Schulte M., Arduino M.J., Aguero S., Fisher D.J., Stechenberg B.W., Banerjee S.N., and Jarvis W.R. Serratia marcescens outbreak associated with extrinsic contamination of 1% chlorxylenol soap. Infect. Control Hosp. Epidemiol. 18 (1997) 704-709
6. Archibald L.K., Manning M.L., Bell L.M., Banerjee S., and Jarvis W.R. Patient density, nurse-to-patient ratio and nosocomial infection risk in a pediatric cardiac intensive care unit. Pediatr. Infect. Dis. J. 16 (1997) 1045-1048
7. Assadian O., Berger A., Aspock C., Mustafa S., Kohlhauser C., and Hirschl A.M. Nosocomial outbreak of Serratia marcescens in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 23 (2002) 457-461
8. Ayalew K., Nambiar S., Yasinskaya Y., and Jantausch B.A. Carbapenems in pediatrics. Ther. Drug. Monit. 25 (2003) 593-599
9. Baker R.M. The price of cost savings. Clin. J. Pain. 24 (2008) 381-383
10. Bates C.J., and Pearse R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J. Hosp. Infect. 61 (2005) 364-366
11. Ben-Abraham R., Keller N., Szold O., Vardi A., Weinberg M., Barzilay Z., and Paret G. Do isolation rooms reduce the rate of nosocomial infections in the pediatric intensive care unit?. J. Crit. Care. 17 (2002) 176-180
12. Berger A., Rohrmeister K., Haiden N., Assadian O., Kretzer V., and Kohlhauser C. Serratia marcescens in the neonatal intensive care unit: re-emphasis of the potentially devastating sequelae. Wien. Klin. Wochenschr. 114 (2002) 1017-1022
13. Boyce J.M., and Pittet D. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Infect. Control Hosp. Epidemiol. 23 (2002) S3-40
14. Campbell J.R., Zaccaria E., Mason Jr. E.O., and Baker C.J. Epidemiological analysis defining concurrent outbreaks of Serratia marcescens and methicillin-resistant Staphylococcus aureus in a neonatal intensive-care unit. Infect. Control Hosp. Epidemiol. 19 (1998) 924-928
15. Casolari C., Pecorari M., Fabio G., Cattani S., Venturelli C., Piccinini L., Tamassia M.G., Gennari W., Sabbatini A.M., and Leporati G.etal. A simultaneous outbreak of Serratia marcescens and Klebsiella pneumoniae in a neonatal intensive care unit. J. Hosp. Infect. 61 (2005) 312-320
16. Cimolai N., Trombley C., Wensley D., and LeBlanc J. Heterogeneous Serratia marcescens genotypes from a nosocomial pediatric outbreak. Chest 111 (1997) 194-197
17. Coffin S.E., and Zaoutis T.E. Infection control, hospital epidemiology, and patient safety. Infect. Dis. Clin. North Am. 19 (2005) 647-665
18. Cordero L., Sananes M., and Ayers L.W. Comparison of a closed (Trach Care MAC) with an open endotracheal suction system in small premature infants. J. Perinatol. 20 (2000) 151-156
19. Crivaro V., Bagattini M., Salza M.F., Raimondi F., Rossano F., Triassi M., and Zarrilli R. Risk factors for extended-spectrum beta-lactamase-producing Serratia marcescens and Klebsiella pneumoniae acquisition in a neonatal intensive care unit. J. Hosp. Infect. 67 (2007) 135-141
20. Cullen M.M., Trail A., Robinson M., Keaney M., and Chadwick P.R. Serratia marcescens outbreak in a neonatal intensive care unit prompting review of decontamination of laryngoscopes. J. Hosp. Infect. 59 (2005) 68-70
21. Dancer S.J. The problem with cephalosporins. J. Antimicrob. Chemother. 48 (2001) 463-478
22. David M.D., Weller T.M., Lambert P., and Fraise A.P. An outbreak of Serratia marcescens on the neonatal unit: a tale of two clones. J. Hosp. Infect. 63 (2006) 27-33
23. Davies M.W., Mehr S., Garland S.T., and Morley C.J. Bacterial colonization of toys in neonatal intensive care cots. Pediatrics 106 (2000) E18
24. Donskey C.J. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin. Infect. Dis. 39 (2004) 219-226
25. Duggan T.G., Leng R.A., Hancock B.M., and Cursons R.T. Serratia marcescens in a newborn unit - microbiological features. Pathology 16 (1984) 189-191
26. Espinosa de los Monteros L.E., Silva-Sanchez J., Jimenez L.V., Rojas T., Garza-Ramos U., and Valverde V. Outbreak of infection by extended-spectrum beta-lactamase SHV-5-producing Serratia marcescens in a Mexican hospital. J. Chemother. 20 (2008) 586-592
27. Exner M., Kramer A., Lajoie L., Gebel J., Engelhart S., and Hartemann P. Prevention and control of health care-associated waterborne infections in health care facilities. Am. J. Infect. Control 33 (2005) S26-40
28. Falagas M.E., Giannopoulou K., Kokolakis G., and Rafailidis P.I. Fosfomycin: use beyond urinary tract and gastrointestinal infections. Clin. Infect. Dis. 46 (2008) 1069-1077
29. Fleisch F., Zimmermann-Baer U., Zbinden R., Bischoff G., Arlettaz R., Waldvogel K., Nadal D., and Ruef C. Three consecutive outbreaks of Serratia marcescens in a neonatal intensive care unit. Clin. Infect. Dis. 34 (2002) 767-773
30. Fleming K., and Randle J. Toys - friend or foe? A study of infection risk in a paediatric intensive care unit. Paediatr. Nurs. 18 (2006) 14-18
31. Foglia E.E., Fraser V.J., and Elward A.M. Effect of nosocomial infections due to antibiotic-resistant organisms on length of stay and mortality in the pediatric intensive care unit. Infect. Control Hosp. Epidemiol. 28 (2007) 299-306
32. Friedman N.D., Kotsanas D., Brett J., Billah B., and Korman T.M. Investigation of an outbreak of Serratia marcescens in a neonatal unit via a case-control study and molecular typing. Am. J. Infect. Control 36 (2008) 22-28
33. Gastmeier P., Stamm-Balderjahn S., Hansen S., Nietzschke-Tiemann F., Zuschneid I., Groneberg K., and Ruden H. Use of information on nosocomial outbreaks for infection control. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47 (2004) 334-338
34. Graham III P.L., Begg M.D., Larson E., Della-Latta P., Allen A., and Saiman L. Risk factors for late onset gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit. Pediatr. Infect. Dis. J. 25 (2006) 113-117
35. Gransden W.R., Webster M., French G.L., and Phillips I. An outbreak of Serratia marcescens transmitted by contaminated breast pumps in a special care baby unit. J. Hosp. Infect. 7 (1986) 149-154
36. Guler E., Davutoglu M., Ucmak H., Karabiber H., and Kokoglu O.F. An outbreak of Serratia marcescens septicemia in neonates. Indian Pediatr. 46 (2009) 61-63
37. Haley R.W., Cushion N.B., Tenover F.C., Bannerman T.L., Dryer D., Ross J., Sanchez P.J., and Siegel J.D. Eradication of endemic methicillin-resistant Staphylococcus aureus infections from a neonatal intensive care unit. J. Infect. Dis. 171 (1995) 614-624
38. Harbarth S., Sudre P., Dharan S., Cadenas M., and Pittet D. Outbreak of Enterobacter cloacae related to understaffing, overcrowding, and poor hygiene practices. Infect. Control Hosp. Epidemiol. 20 (1999) 598-603
39. Hota B. Contamination, disinfection, and cross-colonization: are hospital surfaces reservoirs for nosocomial infection?. Clin. Infect. Dis. 39 (2004) 1182-1189
40. Hota S., Hirji Z., Stockton K., Lemieux C., Dedier H., Wolfaardt G., and Gardam M.A. Outbreak of multidrug-resistant Pseudomonas aeruginosa colonization and infection secondary to imperfect intensive care unit room design. Infect. Control Hosp. Epidemiol. 30 (2009) 25-33
41. Hugonnet S., Harbarth S., Sax H., Duncan R.A., and Pittet D. Nursing resources: a major determinant of nosocomial infection?. Curr. Opin. Infect. Dis. 17 (2004) 329-333
42. Jang T.N., Fung C.P., Yang T.L., Shen S.H., Huang C.S., and Lee S.H. Use of pulsed-field gel electrophoresis to investigate an outbreak of Serratia marcescens infection in a neonatal intensive care unit. J. Hosp. Infect. 48 (2001) 13-19
43. Jones B.L., Gorman L.J., Simpson J., Curran E.T., McNamee S., Lucas C., Michie J., Platt D.J., and Thakker B. An outbreak of Serratia marcescens in two neonatal intensive care units. J. Hosp. Infect. 46 (2000) 314-319
44. Kramer A., Schwebke I., and Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect. Dis. 6 (2006) 130
45. Lai K.K., Baker S.P., and Fontecchio S.A. Rapid eradication of a cluster of Serratia marcescens in a neonatal intensive care unit: use of epidemiologic chromosome profiling by pulsed-field gel electrophoresis. Infect. Control Hosp. Epidemiol. 25 (2004) 730-734
46. Lam B.C., Lee J., and Lau Y.L. Hand hygiene practices in a neonatal intensive care unit: a multimodal intervention and impact on nosocomial infection. Pediatrics 114 (2004) e565-e571
47. Larson E.L., Cimiotti J.P., Haas J., Nesin M., Allen A., Della-Latta P., and Saiman L. Gram-negative bacilli associated with catheter-associated and non-catheter-associated bloodstream infections and hand carriage by healthcare workers in neonatal intensive care units. Pediatr. Crit. Care Med. 6 (2005) 457-461
48. Manning M.L., Archibald L.K., Bell L.M., Banerjee S.N., and Jarvis W.R. Serratia marcescens transmission in a pediatric intensive care unit: a multifactorial occurrence. Am. J. Infect. Control 29 (2001) 115-119
49. Maragakis L.L., Winkler A., Tucker M.G., Cosgrove S.E., Ross T., Lawson E., Carroll K.C., and Perl T.M. Outbreak of multidrug-resistant Serratia marcescens infection in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 29 (2008) 418-423
50. Mattner F., and Gastmeier P. Bacterial contamination of multiple-dose vials: a prevalence study. Am. J. Infect. Control 32 (2004) 12-16
51. McNaughton M., Mazinke N., and Thomas E. Newborn conjunctivitis associated with triclosan 0.5% antiseptic intrinsically contaminated with Serratia marcescens. Can. J. Infect. Control 10 (1995) 7-8
52. Milisavljevic V., Wu F., Larson E., Rubenstein D., Ross B., Drusin L.M., Della-Latta P., and Saiman L. Molecular epidemiology of Serratia marcescens outbreaks in two neonatal intensive care units. Infect. Control Hosp. Epidemiol. 25 (2004) 719-721
53. Miranda-Novales G., Leanos-Miranda B., Diaz-Ramos R., Gonzalez-Tejeda L., Peregrino-Bejarano L., Villegas-Silva R., and Solorzano-Santos F. An outbreak due to Serratia marcescens in a neonatal intensive care unit typed by 2-day pulsed field gel electrophoresis protocol. Arch. Med. Res. 34 (2003) 237-241
54. Miranda G., Kelly C., Solorzano F., Leanos B., Coria R., and Patterson J.E. Use of pulsed-field gel electrophoresis typing to study an outbreak of infection due to Serratia marcescens in a neonatal intensive care unit. J. Clin. Microbiol. 34 (1996) 3138-3141
55. Montanaro D., Grasso G.M., Annino I., De Ruggiero N., Scarcella A., and Schioppa F. Epidemiological and bacteriological investigation of Serratia marcescens epidemic in a nursery and in a neonatal intensive care unit. J. Hyg. (Lond) 93 (1984) 67-78
56. Nicolau D.P. Pharmacokinetic and pharmacodynamic properties of meropenem. Clin. Infect. Dis. 47 Suppl 1 (2008) S32-40
57. Prasad G.A., Jones P.G., Michaels J., Garland J.S., and Shivpuri C.R. Outbreak of Serratia marcescens infection in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 22 (2001) 303-305
58. Rabier V., Bataillon S., Jolivet-Gougeon A., Chapplain J.M., Beuchee A., and Betremieux P. Hand washing soap as a source of neonatal Serratia marcescens outbreak. Acta Paediatr. 97 (2008) 1381-1385
59. Randle J., and Fleming K. The risk of infection from toys in the intensive care setting. Nurs. Stand. 20 (2006) 50-54
60. Raymond J., and Aujard Y. Nosocomial infections in pediatric patients: a European, multicenter prospective study. European Study Group. Infect. Control Hosp. Epidemiol. 21 (2000) 260-263
61. Sarvikivi E., Lyytikainen O., Salmenlinna S., Vuopio-Varkila J., Luukkainen P., Tarkka E., and Saxen H. Clustering of Serratia marcescens infections in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 25 (2004) 723-729
62. Simon A., Krawtschenko O., Reiffert S.M., Exner M., Trautmann M., and Engelhart S. Outbreaks of Pseudomonas aeruginosa in pediatric patients - clinical aspects, risk factors and management. J. Pediatr. Infect. Dis. 3 (2008) 249-269
63. Steppberger K., Walter S., Claros M.C., Spencker F.B., Kiess W., Rodloff A.C., and Vogtmann C. Nosocomial neonatal outbreak of Serratia marcescens - analysis of pathogens by pulsed field gel electrophoresis and polymerase chain reaction. Infection 30 (2002) 277-281
64. Uduman S.A., Farrukh A.S., Nath K.N., Zuhair M.Y., Ifrah A., Khawla A.D., and Sunita P. An outbreak of Serratia marcescens infection in a special-care baby unit of a community hospital in United Arab Emirates: the importance of the air conditioner duct as a nosocomial reservoir. J. Hosp. Infect. 52 (2002) 175-180
65. van Ogtrop M.L., van Zoeren-Grobben D., Verbakel-Salomons E.M., and van Boven C.P. Serratia marcescens infections in neonatal departments: description of an outbreak and review of the literature. J. Hosp. Infect. 36 (1997) 95-103
66. Vandenberghe A., Laterre P., Goenen M., Reynaert M., Wittebole X., Simon A., and Haxhe J.J. Surveillance of hospital-acquired infections in an intensive care department-the benefit of the full-time presence of an infection control nurse. J. Hosp. Infect. 52 (2002) 56-59
67. Vandenbroucke-Grauls C., and Schultsz C. Surveillance in infection control: are we making progress?. Curr. Opin. Infect. Dis. 15 (2002) 415-419
68. Villari P., Crispino M., Salvadori A., and Scarcella A. Molecular epidemiology of an outbreak of Serratia marcescens in a neonatal intensive care unit. Infect. Control Hosp. Epidemiol. 22 (2001) 630-634
69. Yang K., and Guglielmo B.J. Diagnosis and treatment of extended-spectrum and AmpC beta-lactamase-producing organisms. Ann. Pharmacother. 41 (2007) 1427-1435