Dexmedetomidine, an α-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion

Journal of Thoracic and Cardiovascular Surgery

Volumn 147, Issue 1, 2014, Pages 500-507

  Bell, Marshall T ^a   Puskas, Ferenc ^a   Bennett, Daine T ^a   Herson, Paco S ^a   Quillinan, Nidia ^a   Fullerton, David A ^a   Reece, T Brett ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXMEDETOMIDINE; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA OCCLUSION; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; HISTOPATHOLOGY; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPINAL CORD ISCHEMIA; STERNOTOMY;

26.1; 38; 38.1; B-CELL LYMPHOMA 2; BCL-2; BDNF; BRAIN-DERIVED NEUROTROPHIC FACTOR; CREB; CYCLIC AMP RESPONSE-ELEMENT BINDING PROTEIN; IR; ISCHEMIA-REPERFUSION; PBS; PHOSPHATE BUFFERED SALINE;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; AORTA, THORACIC; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONSTRICTION; CREB-BINDING PROTEIN; DEXMEDETOMIDINE; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ADRENERGIC, ALPHA-2; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD ISCHEMIA; TIME FACTORS;

EID: 84890553350     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2013.07.043     Document Type: Conference Paper

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