Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

Brain Research

Volumn 1494, Issue , 2013, Pages 1-8

  Zhu, Yong Man ^a   Wang, Can Can ^b   Chen, Long ^a   Qian, Ling Bo ^a   Ma, Lei Lei ^a   Yu, Jing ^a   Zhu, Man Hua ^a   Wen, Chuan Yun ^a   Yu, Li Na ^a   Yan, Min ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Dexmedetomidine; ERK1 2; GSK 3 ; MCAO; PI3K

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; DEXMEDETOMIDINE; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ARTICLE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; CLINICAL EVALUATION; CONTROLLED STUDY; DOWN REGULATION; HEMISPHERE; HIPPOCAMPUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; CELL DEATH; CEREBRAL CORTEX; DEXMEDETOMIDINE; GLYCOGEN SYNTHASE KINASE 3; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84872348600     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.11.047     Document Type: Article

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